期刊
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
卷 2021, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2021/4582412
关键词
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资金
- Regional Joint Fund of the National Natural Science Foundation of China [U19A2010]
- National Natural Science Foundation of China [81891012, 82003879]
- Outstanding Talents Fund of Double First-Class Initiative Construction of Chengdu University of Traditional Chinese Medicine [2020JCRC005, 2020QNJS002]
- Key Project of Science and Technology Department of Sichuan Province [20ZDYF3092]
- Central Guided Local Special Project Southwestern Characteristic Chinese Medicine Resource Genomics Innovation Platform [2020ZYD058]
- Key RD Project [2018JZ0081]
Rhein, as one of the main active components of rhubarb and Polygonum multiflorum, has various pharmacological effects such as cardiocerebral protective, hepatoprotective, nephroprotective, anti-inflammatory, antitumor, and antidiabetic effects. However, its poor water solubility, low bioavailability, and potential liver and kidney toxicity limit its clinical application.
Rhein, belonging to anthraquinone compounds, is one of the main active components of rhubarb and Polygonum multiflorum. Rhein has a variety of pharmacological effects, such as cardiocerebral protective effect, hepatoprotective effect, nephroprotective effect, anti-inflammation effect, antitumor effect, antidiabetic effect, and others. The mechanism is interrelated and complex, referring to NF-kappa B, PI3K/Akt/MAPK, p53, mitochondrial-mediated signaling pathway, oxidative stress signaling pathway, and so on. However, to some extent, its clinical application is limited by its poor water solubility and low bioavailability. Even more, rhein has potential liver and kidney toxicity. Therefore, in this paper, the pharmacological effects of rhein and its mechanism, pharmacokinetics, and safety studies were reviewed, in order to provide reference for the development and application of rhein.
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