Article
Immunology
Xiaofei Li, Jing Zhao, Said Movahedi Naini, Gianmarco Sabiu, Stefan G. Tullius, Su Ryon Shin, Jonathan S. Bromberg, Paolo Fiorina, George C. Tsokos, Reza Abdi, Vivek Kasinath
Summary: The study revealed that after unilateral ureteral obstruction in the kidney, fibroblastic reticular cells (FRCs) in the kidney-draining lymph node also become fibrogenic, contributing to fibrosis that closely mirrors changes in the kidney. Additionally, immune cell populations in the affected lymph node were significantly higher compared to the unaffected contralateral kidney-draining lymph node. This suggests a possible mechanism for fibrosis involving the TGF beta/TGF beta R signaling pathway, and future studies are needed to delve deeper into this connection between FRCs and lymph node fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
John D. Imig, Md Abdul Hye Khan, Anna Stavniichuk, Wojciech K. Jankiewicz, Samaneh Goorani, Michael M. Yeboah, Ashraf El-Meanawy
Summary: The incidence of ureter obstruction is increasing and recovery from this kidney injury can lead to long-term consequences such as an increased risk for salt-sensitive hypertension. A study using a RUUO model found that mice with unilateral ureteral obstruction had elevated blood pressure and decreased sodium excretion, along with renal tubular injury, inflammation, decreased vascular density, and renal fibrosis. These findings highlight the importance of addressing ureter obstruction and its potential impact on sodium excretion and hypertension.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Stine Julie Tingskov, Michael Schou Jensen, Casper-Emil Tingskov Pedersen, Isabela Bastos Binotti Abreu de Araujo, Henricus A. M. Mutsaers, Rikke Norregaard
Summary: The study found that the selective estrogen receptor modulator tamoxifen has a mitigating effect on renal fibrosis in female, male, and ovariectomized female rats, as well as demonstrating an anti-fibrotic effect in human kidney slices. Gender differences may play a role in drug treatment response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Laura Gabriela Sanchez-Lozada, Fernando Enrique Garcia-Arroyo, Isabel Amador-Martinez, Marisol Orozco-Ibarra, Francisca Fernandez-Valverde, Jose Pedraza-Chaverri
Summary: Sulforaphane (SFN) confers protection against unilateral ureteral obstruction (UUO)-induced kidney injury by targeting mitochondrial biogenesis and improving lipid metabolism.
Article
Biochemistry & Molecular Biology
Ariadna Jazmin Ortega-Lozano, Alexis Paulina Jimenez-Uribe, Ana Karina Aranda-Rivera, Leopoldo Gomez-Caudillo, Emmanuel Rios-Castro, Edilia Tapia, Belen Bellido, Omar Emiliano Aparicio-Trejo, Laura Gabriela Sanchez-Lozada, Jose Pedraza-Chaverri
Summary: The study examined the impact of UUO at different time points on the mitochondrial proteome of rat kidneys, revealing changes in proteins related to oxidative phosphorylation, the tricarboxylic acid cycle, and fatty acid metabolism, all of which are associated with bioenergetics during ON.
Article
Biochemistry & Molecular Biology
Minghua Xian, Jiale Cai, Kening Zheng, Qu Liu, Yali Liu, Huiting Lin, Shengwang Liang, Shumei Wang
Summary: AE has a protective effect against cerebral ischemia-reperfusion injury, possibly through the PI3K/AKT/mTOR and NF-kappa B signaling pathways.
Article
Medicine, Research & Experimental
Hui Gong, Xing Lyu, Yang Liu, Naling Peng, Shengyu Tan, Lini Dong, Xiangyu Zhang
Summary: Eupatilin alleviates pulmonary fibrosis through the Sestrin2/PI3K/Akt/mTOR-dependent autophagy pathway, reducing the expression of fibrotic markers. This study provides a new insight and potential drug target for the treatment of IPF.
Article
Chemistry, Medicinal
Ai-Yuan Xiu, Qian Ding, Zhen Li, Chun-Qing Zhang
Summary: Doxazosin inhibits autophagy by activating the PI3K/Akt/mTOR signaling pathway, attenuating liver fibrosis. It also blocks HSC proliferation and migration, inducing cell apoptosis in a concentration-dependent manner. Additionally, doxazosin activates the PI3K/Akt/mTOR pathway which regulates fibrosis, autophagy, and apoptosis in HSCs.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Alexis Paulina Jimenez-Uribe, Belen Bellido, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Laura Gabriela Sanchez-Lozada, Jose Antonio Hernandez-Santos, Francisca Fernandez-Valverde, Estefani Yaquelin Hernandez-Cruz, Marisol Orozco-Ibarra, Jose Pedraza-Chaverri
Summary: This study evaluated the time course of mitochondrial mass and bioenergetics alterations induced by a unilateral ureteral obstruction (UUO), a widely used model to study kidney fibrosis induction and progression mechanisms. The results showed a marked reduction in mitochondrial oxidative phosphorylation (OXPHOS) and mitochondrial mass during days 7 to 28 of obstruction, suggesting a key role of mitochondrial biogenesis and mitophagy induction in the impairment of OXPHOS capacity during fibrotic progression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yi-Hsin Lo, Shun-Fa Yang, Ching-Chang Cheng, Kuo-Chiang Hsu, Yu-Syuan Chen, Yu-Ya Chen, Chun-Wei Wang, Siao-Syun Guan, Cheng-Tien Wu
Summary: This study demonstrated the beneficial effects of Nobiletin in improving the progression of chronic kidney disease. Nobiletin was found to alleviate kidney fibrosis, oxidative stress, and inflammatory response. It may serve as a potential therapeutic candidate for the treatment of progressive chronic kidney disease.
Article
Geriatrics & Gerontology
Jieting Peng, Xun Xiao, Shizhen Li, Xing Lyu, Hui Gong, Shengyu Tan, Lini Dong, Yan Y. Sanders, Xiangyu Zhang
Summary: This study investigates the effects of aspirin on lung fibroblast differentiation and pulmonary fibrosis. The results show that aspirin reduces the expression of fibrotic markers, promotes autophagy, and decreases lung fibrosis. The mechanism involves the PI3K/AKT/mTOR-dependent autophagy pathway.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Medicine, Research & Experimental
Honglin Yu, Jingbo Zhu, Lingyu Chang, Chaozhao Liang, Xiaohu Li, Wei Wang
Summary: The study showed that 3-BrPA significantly suppressed kidney injury and interstitial collagen production, as well as attenuated ECM accumulation in a dose-dependent manner. Additionally, 3-BrPA inhibited FMT and TGF-beta 1-induced fibroblast proliferation through potential IRAK4/MYC signal pathways.
Article
Nutrition & Dietetics
Chang-Mu Chen, Chen-Yu Lin, Yao-Pang Chung, Chia-Hung Liu, Kuo-Tong Huang, Siao-Syun Guan, Cheng-Tien Wu, Shing-Hwa Liu
Summary: Nootkatone, a major active ingredient of Alpiniae oxyphyllae, has shown promising effects in preventing and mitigating the progression of chronic kidney diseases (CKD) in a unilateral ureteral obstructive (UUO) mouse model. It was found to reduce pathological changes, collagen deposition, fibrotic markers expression, oxidative stress-induced injury, inflammatory cell infiltration, and renal cell apoptotic death in the kidneys of UUO mice. This suggests that nootkatone may be a potential therapeutic candidate for intervening in CKD.
Article
Biochemistry & Molecular Biology
Cheng-Chieh Hung, Kuan-Hsing Chen, Hsiang-Hao Hsu, Ming-Yang Chang, Yi-Ching Ko, Huang-Yu Yang, Chih-Wei Yang
Summary: Noscapine has been found to alleviate renal fibrosis by reducing inflammation and inhibiting fibroblast transformation induced by TGF-beta 1, making it a potential therapeutic agent for inhibiting tubulointerstitial fibrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Review
Biochemistry & Molecular Biology
Stefano Ratti, Raffaella Mauro, Cristina Rocchi, Sara Mongiorgi, Giulia Ramazzotti, Mauro Gargiulo, Lucia Manzoli, Lucio Cocco, Roberta Fiume
Summary: This review examines the importance of critical enzymes such as PI3K, AKT, and mTOR in the maturation and failure of arteriovenous fistula (AVF) for haemodialysis treatment. These enzymes play a role in various cellular activities and are associated with multiple diseases. They are also druggable targets, which can be targeted to control specific aspects of AVF and provide more personalized therapy.
Article
Plant Sciences
Yu-cheng Liao, Jing-wen Wang, Juan-li Zhang, Chao Guo, Xin-liang Xu, Kai Wang, Chao Zhao, Ai-dong Wen, Rui-li Li, Yi Ding
Summary: QFZTC contains seven active ingredients identified through HPLC, with network pharmacology analysis revealing TLR4, TNF, IL6, IL1 beta, and c-Fos as core targets. Through regulating the TLR4/MyD88/NF-kappa B signaling pathway in spinal microglia, QFZTC significantly alleviated neuropathic pain in mice models.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dongmei Hu, Shaojie Huang, Yi Ding, Xian Zhao, Wei Zhang, Haixia Chen, Jingwen Wang
Summary: The hepatoprotective effects of specnuezhenide against CCl4-induced liver injury in mice were investigated. Specnuezhenide reduced liver injury by inhibiting oxidative stress via activation of Nrf2 signaling and decreasing hepatocyte apoptosis.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Plant Sciences
Wei Zhang, Li Zhang, Wen Jun Wang, Shanbo Ma, Mingming Wang, Minna Yao, Ruili Li, Wei Wei Li, Xian Zhao, Dongmei Hu, Yi Ding, Jingwen Wang
Summary: The study found that Sanhua decoction regulates the PI3K/Akt/CREB1 and TNF pathways to protect against cerebral ischaemic injury.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yucheng Liao, Jingwen Wang, Chao Guo, Min Bai, Bowei Ju, Zheng Ran, Junping Hu, Jianhua Yang, Aidong Wen, Yi Ding
Summary: This study explored the active components, core targets, and synergistic mechanisms of Frankincense-Myrrh in the treatment of cerebrovascular diseases (CBVDs) using systems pharmacology and experimental research. The results showed that Frankincense-Myrrh mainly regulated neurotrophic factors and inflammatory responses, leading to significant improvements in neurological function and reduction in infarct volume.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Mingming Wang, Jiaoyan Yu, Qi Yang, Chao Guo, Wei Zhang, Weiwei Li, Yan Weng, Yi Ding, Jingwen Wang
Summary: This study demonstrated that beta-BA exerts neuroprotective effects against cerebral I/R injury by activating the PRKCE/NFE2L2/HMOX1 pathway, improving neurological deficits in animals and protecting neurons in in vitro experiments.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Cell Biology
Chao Guo, Wen-Jun Wang, Yu-Cheng Liao, Chao Zhao, Ying Yin, Min-Na Yao, Yi Ding, Jing-Wen Wang
Summary: Quercetin, extracted from tea, onions, and apples, has a neuroprotective effect on experimental ischemic stroke. This systematic review and meta-analysis found that quercetin significantly improved neurological function score and reduced infarct volume. It also alleviated blood-brain barrier permeability and brain water content. The mechanisms of quercetin against focal cerebral ischemia involve antioxidation, antiapoptotic, anti-inflammation, and calcium overload reduction. Although the effect size may be overestimated due to study quality and publication bias, quercetin shows potential as a neuroprotective agent for human ischemic stroke.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Plant Sciences
Yucheng Liao, Chao Guo, Aidong Wen, Min Bai, Zheng Ran, Junping Hu, Jingwen Wang, Jianhua Yang, Yi Ding
Summary: This study aimed to further elucidate the protective effects associated with the Frankincense-Myrrh treatment of neuropathic pain (NP). The results showed that treatment with Frankincense and Myrrh significantly alleviated thermal and mechanical hypersensitivity in NP model mice. Network pharmacology analyses suggested that the pathogenesis of NP may be related to TLR4/MyD88-mediated neuroinflammation, and Frankincense-Myrrh treatment was found to inhibit TLR4/MyD88 pathway and TRPV1 signaling activity, thus alleviating NP.
Article
Biochemistry & Molecular Biology
Wei Liu, Miaomiao Wang, Zhongjie Guo, Youyou He, Hairui Jia, Jin He, Shanshan Miao, Yi Ding, Shengzheng Wang
Summary: Bis-fl-carboline alkaloids, a promising drug-like scaffold, were synthesized via a one-pot condensation-Mannich reaction. The simplified derivatives displayed potent antitumor activity, including anti-migration, anti-invasion, antiangiogenic, and vascular-disrupting properties. Mechanistic studies revealed their inhibition of Top1 and Top2 activity, interfering with DNA synthesis in cancer cells. This study developed a new synthetic methodology and provided a promising lead structure for antitumor drug discovery.
BIOORGANIC CHEMISTRY
(2023)
Article
Plant Sciences
Yu-cheng Liao, Jing-wen Wang, Chao Guo, Min Bai, Zheng Ran, Bo-wei Ju, Yi Ding, Jun-ping Hu, Jian-hua Yang
Summary: This study aimed to investigate the curative effect and underlying mechanism of the traditional medicinal Cistanche tubulosa (CT) on ischemic stroke (IS). The results showed that CT improved blood-brain barrier integrity and neurological function, and protected against cerebral ischemia injury. The study revealed that CT influenced neuroinflammation by regulating microglial polarization. These findings provide theoretical and experimental evidence for the efficacy of CT therapy and prevention of cerebral ischemic injuries.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Food Science & Technology
Wenjun Wang, Tianlong Liu, Yi Ding, Yi Zhang
Summary: Epidemiological studies suggest that polyphenols may improve sleep quality, but the results are controversial. This study aimed to provide a general overview of the effects of polyphenol interventions on sleep disorders. Analysis of eligible randomized controlled trials showed that polyphenols can reduce sleep onset latency and increase total sleep time, but have no effect on sleep efficiency and PSQI. Subgroup analyses indicated that treatment duration, study design, and participant number were the main factors influencing the heterogeneity of the results. These findings highlight the potential therapeutic importance of polyphenols in treating sleep disorders.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Min Bai, Na Cui, Yucheng Liao, Chao Guo, Liang Li, Ying Yin, Aidong Wen, Jingwen Wang, Weiliang Ye, Yi Ding
Summary: Cerebral ischemia-reperfusion injury (CI/RI) is the main cause of disability and death in stroke. Danshensu (DSS) has anti-inflammatory effects, but its low cellular permeability and bioavailability limit its effectiveness. In this study, a new DSS preparation was developed using liposomes modified with phosphatidylserine (PS) and transferrin (TF) to improve the treatment of ischemic stroke. This formulation can cross the blood-brain barrier and target inflammatory glial cells, reducing inflammation and improving brain injury.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Gastroenterology & Hepatology
Ke-Xin Sun, Shan-Shan Cao, Feng-Hao Shi, Yue Guan, Meng Tang, Mei-na Zhao, Yu-Fan Jian, Bin Cui, Zhi-Yan Li, Jing-Wen Wang, Feng Yu, Yi Ding
Summary: This study evaluates the cost-effectiveness of first-line strategies in advanced hepatocellular carcinoma (aHCC) patients from the perspective of Chinese and US payers. The findings suggest that lenvatinib (LEVA) is the most cost-effective strategy in both China and the United States.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Review
Education & Educational Research
Jingjie Zhao, Kaiyuan Zhou, Yi Ding
Summary: A meta-analysis on the application of digital games in medical education revealed that compared to traditional methods, digital games significantly improve learners' knowledge and satisfaction, especially in long-term retention of knowledge. While no significant difference was found in overall knowledge outcomes compared to other digital methods, the majority of learners preferred using digital games.
ASIA-PACIFIC EDUCATION RESEARCHER
(2022)