Progressive enhancement of kinetic proofreading in T cell antigen discrimination from receptor activation to DAG generation

Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor

(2022) Jesse Goyette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands

(2021) Lin Shen et al.   Science Signaling

Quantifying persistence in the T‐cell signaling network using an optically controllable antigen receptor

(2021) Michael J Harris et al.   Molecular Systems Biology

The discriminatory power of the T cell receptor

(2021) Johannes Pettmann et al.   eLife

SciPy 1.0: fundamental algorithms for scientific computing in Python

(2020) Pauli Virtanen et al.   NATURE METHODS

Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants

(2020) Yael Korem Kohanim et al.   IMMUNITY

HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis

(2020) Jian Wang et al.   CELL

How the T cell signaling network processes information to discriminate between self and agonist ligands

(2020) Raman S. Ganti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events

(2019) Jenny J. Y. Lin et al.   Science Signaling

TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps

(2019) Jason Yi et al.   Nature Communications

A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS

(2019) William Y. C. Huang et al.   SCIENCE

Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling

(2019) Doug K Tischer et al.   eLife

Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination

(2019) Wan-Lin Lo et al.   NATURE IMMUNOLOGY

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT

(2018) Wan-Lin Lo et al.   NATURE IMMUNOLOGY

TCR Signaling: Mechanisms of Initiation and Propagation

(2018) Adam H. Courtney et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation

(2018) Yair Razvag et al.   Nature Communications

TrackMate: An open and extensible platform for single-particle tracking

(2017) Jean-Yves Tinevez et al.   METHODS

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters

(2015) Lakshmi Balagopalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A general method to improve fluorophores for live-cell and single-molecule microscopy

(2015) Jonathan B Grimm et al.   NATURE METHODS

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

(2015) Sudha Kumari et al.   eLife

Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance

(2014) Ondrej Stepanek et al.   CELL

Relevance of Nck-CD3  Interaction for T Cell Activation In Vivo

(2014) A. Borroto et al.   JOURNAL OF IMMUNOLOGY

Insights into the initiation of TCR signaling

(2014) Arup K Chakraborty et al.   NATURE IMMUNOLOGY

scikit-image: image processing in Python

(2014) Stéfan van der Walt et al.   PeerJ

Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling

(2013) Ying Xim Tan et al.   NATURE IMMUNOLOGY

Identification of a Titin-Derived HLA-A1-Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3-Directed T Cells

(2013) B. J. Cameron et al.   Science Translational Medicine

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

(2013) Geoff P O'Donoghue et al.   eLife

Structural basis for self-recognition by autoimmune T-cell receptors

(2012) Yiyuan Yin et al.   IMMUNOLOGICAL REVIEWS

Biophysical mechanism of T-cell receptor triggering in a reconstituted system

(2012) John R. James et al.   NATURE

Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor

(2011) Eilon Sherman et al.   IMMUNITY

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters

(2011) B. N. Manz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling

(2011) J. R. Schoenborn et al.   Science Signaling

Viral evasion of T cell immunity: ancient mechanisms offering new applications

(2010) Daniëlle Horst et al.   CURRENT OPINION IN IMMUNOLOGY

Distinctive CD3 Heterodimeric Ectodomain Topologies Maximize Antigen-Triggered Activation of    T Cell Receptors

(2010) S. T. Kim et al.   JOURNAL OF IMMUNOLOGY

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

T-Cell Signaling Regulated by the Tec Family Kinase, Itk

(2010) A. H. Andreotti et al.   Cold Spring Harbor Perspectives in Biology

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response

(2009) S. Deindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic Control of Histidine-Tagged Protein Surface Density on Supported Lipid Bilayers

(2008) Jeffrey A. Nye et al.   LANGMUIR

Estimation of the available free energy in a LOV2-Jα photoswitch

(2008) Xiaolan Yao et al.   Nature Chemical Biology