TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT

(2018) Wan-Lin Lo et al.   NATURE IMMUNOLOGY

Monomeric TCRs drive T cell antigen recognition

(2018) Mario Brameshuber et al.   NATURE IMMUNOLOGY

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

(2018) Lakshmi Balagopalan et al.   Nature Communications

Development of nanoscale structure in LAT-based signaling complexes

(2016) Valarie A. Barr et al.   JOURNAL OF CELL SCIENCE

madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy

(2016) Jason Yi et al.   MOLECULAR BIOLOGY OF THE CELL

A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli

(2016) Zachary B Katz et al.   NATURE IMMUNOLOGY

High-density three-dimensional localization microscopy across large volumes

(2016) Wesley R Legant et al.   NATURE METHODS

Three-dimensional localization of T-cell receptors in relation to microvilli using a combination of superresolution microscopies

(2016) Yunmin Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters

(2015) Lakshmi Balagopalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multitarget super-resolution microscopy with high-density labeling by exchangeable probes

(2015) Tai Kiuchi et al.   NATURE METHODS

Bayesian cluster identification in single-molecule localization microscopy data

(2015) Patrick Rubin-Delanchy et al.   NATURE METHODS

Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics

(2015) D. Li et al.   SCIENCE

Relevance of Nck-CD3  Interaction for T Cell Activation In Vivo

(2014) A. Borroto et al.   JOURNAL OF IMMUNOLOGY

TCR Microclusters Pre-Exist and Contain Molecules Necessary for TCR Signal Transduction

(2014) T. J. Crites et al.   JOURNAL OF IMMUNOLOGY

Insights into the initiation of TCR signaling

(2014) Arup K Chakraborty et al.   NATURE IMMUNOLOGY

Characterization and development of photoactivatable fluorescent proteins for single-molecule-based superresolution imaging

(2014) S. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane raft association is a determinant of plasma membrane localization

(2014) B. B. Diaz-Rohrer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage

(2013) Jason Yi et al.   JOURNAL OF CELL BIOLOGY

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

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Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Correcting chromatic offset in multicolor super-resolution localization microscopy

(2013) Miklos Erdelyi et al.   OPTICS EXPRESS

Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells

(2012) Jason Yi et al.   MOLECULAR BIOLOGY OF THE CELL

Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor

(2011) Eilon Sherman et al.   IMMUNITY

Identification of clustering artifacts in photoactivated localization microscopy

(2011) Paolo Annibale et al.   NATURE METHODS

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation

(2011) L. Balagopalan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse

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TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

Effects of Intracellular Calcium and Actin Cytoskeleton on TCR Mobility Measured by Fluorescence Recovery

(2008) Omer Dushek et al.   PLoS One