TREM2 improves neurological dysfunction and attenuates neuroinflammation, TLR signaling and neuronal apoptosis in the acute phase of intracerebral hemorrhage

TREM2 Ameliorates Lipopolysaccharide-Induced Oxidative Stress Response and Neuroinflammation by Promoting Sirtuin3 in BV2 Cells

(2022) Hongqing Li et al.   NEUROTOXICITY RESEARCH

The role of innate immune genes in Alzheimer's disease

(2021) Ana Griciuc et al.   CURRENT OPINION IN NEUROLOGY

Loss of mural cell-derived laminin aggravates hemorrhagic brain injury

(2020) Jyoti Gautam et al.   Journal of Neuroinflammation

TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice

(2020) Shengpan Chen et al.   Journal of Neuroinflammation

Targeting miR‐124/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model

(2020) Wen‐Dai Bao et al.   AGING CELL

Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation

(2020) Mengzhou Xue et al.   LANCET NEUROLOGY

Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells

(2019) Hui Shi et al.   MOLECULES

Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer’s Disease and Systemic Inflammation

(2019) Jian Zhou et al.   NEUROCHEMICAL RESEARCH

TREM2 Attenuates Aβ1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling

(2019) Huiping Long et al.   NEUROCHEMICAL RESEARCH

The role of TLR4 and HO‐1 in neuroinflammation after subarachnoid hemorrhage

(2019) Yosuke Akamatsu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Association Between Toll‐Like Receptor 4 ( TLR4 ) and Triggering Receptor Expressed on Myeloid Cells 2 ( TREM2 ) Genetic Variants and Clinical Progression of Huntington's Disease

(2019) Romina Vuono et al.   MOVEMENT DISORDERS

TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling

(2018) Caixia Li et al.   CELL BIOLOGY INTERNATIONAL

TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease

(2018) Manru Ren et al.   EXPERIMENTAL NEUROLOGY

Activation of dopamine D1 receptor decreased NLRP3-mediated inflammation in intracerebral hemorrhage mice

(2018) Tian Wang et al.   Journal of Neuroinflammation

A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase

(2018) Tomoki Sugiyama et al.   BRAIN RESEARCH

An Update On Medical Treatment for Intracerebral Hemorrhage

(2018) Xiang Li et al.   Translational Stroke Research

Endogenous hydrogen sulphide attenuates NLRP3 inflammasome-mediated neuroinflammation by suppressing the P2X7 receptor after intracerebral haemorrhage in rats

(2017) Hengli Zhao et al.   Journal of Neuroinflammation

Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage

(2017) Chun-Hu Wu et al.   Journal of Neuroinflammation

Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) Activation Balance Astrocyte Polarization into a Proinflammatory Phenotype

(2017) Gerardo Rosciszewski et al.   MOLECULAR NEUROBIOLOGY

TREM2 protects against cerebral ischemia/reperfusion injury

(2017) Rong Wu et al.   Molecular Brain

Atorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of AQP4 expression in rabbits

(2016) JUN-HUI CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

NF-κB inhibition attenuates LPS-induced TLR4 activation in monocyte cells

(2016) Jian Wan et al.   Molecular Medicine Reports

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

(2016) Honghua Zheng et al.   NEUROBIOLOGY OF AGING

Intravascular Inflammation Triggers Intracerebral Activated Microglia and Contributes to Secondary Brain Injury After Experimental Subarachnoid Hemorrhage (eSAH)

(2016) Etienne Atangana et al.   Translational Stroke Research

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

TREM2 in CNS homeostasis and neurodegenerative disease

(2015) Meghan M. Painter et al.   Molecular Neurodegeneration

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation

(2013) Yu Zhou et al.   PROGRESS IN NEUROBIOLOGY

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

(2011) Hiroaki Ito et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microglial activation in stroke: Therapeutic targets

(2010) Midori A. Yenari et al.   Neurotherapeutics