Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage

Alternative activation-skewed microglia/macrophages promote hematoma resolution in experimental intracerebral hemorrhage

(2017) Che-Feng Chang et al.   NEUROBIOLOGY OF DISEASE

TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage

(2016) Roslyn A. Taylor et al.   JOURNAL OF CLINICAL INVESTIGATION

Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage

(2016) Chun-Hu Wu et al.   Journal of Neuroinflammation

14,15-epoxyeicosatrienoic acid promotes production of brain derived neurotrophic factor from astrocytes and exerts neuroprotective effects during ischaemic injury

(2016) L. Yuan et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress

(2016) Qian Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy

(2015) Yu-Wen Hung et al.   BRAIN BEHAVIOR AND IMMUNITY

Epoxyeicosatrienoic Acids Regulate Macrophage Polarization and Prevent LPS-Induced Cardiac Dysfunction

(2015) Meiyan Dai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epoxyeicosanoid Signaling Provides Multi-target Protective Effects on Neurovascular Unit in Rats After Focal Ischemia

(2015) Yang Liu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The inhibitory effect of mesenchymal stem cell on blood–brain barrier disruption following intracerebral hemorrhage in rats: contribution of TSG-6

(2015) Min Chen et al.   Journal of Neuroinflammation

Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury

(2015) Xiaojing Chen et al.   MOLECULAR NEUROBIOLOGY

Soluble Epoxide Hydrolase in Hydrocephalus, Cerebral Edema, and Vascular Inflammation After Subarachnoid Hemorrhage

(2015) Dominic A. Siler et al.   STROKE

LPS Down-Regulates Specificity Protein 1 Activity by Activating NF-κB Pathway in Endotoxemic Mice

(2015) Xiaobing Ye et al.   PLoS One

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Genetic variation in soluble epoxide hydrolase: association with outcome after aneurysmal subarachnoid hemorrhage

(2014) Ross P. Martini et al.   JOURNAL OF NEUROSURGERY

Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates MPTP-Induced Parkinsonism

(2014) Xiaocui Qin et al.   MOLECULAR NEUROBIOLOGY

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Post-Injury Treatment with 7,8-Dihydroxyflavone, a TrkB Receptor Agonist, Protects against Experimental Traumatic Brain Injury via PI3K/Akt Signaling

(2014) Chun-Hu Wu et al.   PLoS One

Berberine Protects against Neuronal Damage via Suppression of Glia-Mediated Inflammation in Traumatic Brain Injury

(2014) Chien-Cheng Chen et al.   PLoS One

Fingolimod for the Treatment of Intracerebral Hemorrhage

(2014) Ying Fu et al.   JAMA Neurology

(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways

(2014) Che-Feng Chang et al.   Annals of Clinical and Translational Neurology

Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke

(2013) Jafar Sadik B. Shaik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial Responses after Ischemic Stroke and Intracerebral Hemorrhage

(2013) Roslyn A. Taylor et al.   Clinical & Developmental Immunology

Soluble epoxide hydrolase: Gene structure, expression and deletion

(2013) Todd R. Harris et al.   GENE

Inhibition of Soluble Epoxide Hydrolase after Cardiac Arrest/Cardiopulmonary Resuscitation Induces a Neuroprotective Phenotype in Activated Microglia and Improves Neuronal Survival

(2013) Jianming Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The p38  MAPK Regulates Microglial Responsiveness to Diffuse Traumatic Brain Injury

(2013) A. D. Bachstetter et al.   JOURNAL OF NEUROSCIENCE

Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation

(2013) Yu Zhou et al.   PROGRESS IN NEUROBIOLOGY

Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states

(2012) Alok Kumar et al.   NEUROBIOLOGY OF AGING

Wogonin Improves Histological and Functional Outcomes, and Reduces Activation of TLR4/NF-κB Signaling after Experimental Traumatic Brain Injury

(2012) Chien-Cheng Chen et al.   PLoS One

Salidroside Improves Behavioral and Histological Outcomes and Reduces Apoptosis via PI3K/Akt Signaling after Experimental Traumatic Brain Injury

(2012) Szu-Fu Chen et al.   PLoS One

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Caveolin-1 Deletion Reduces Early Brain Injury after Experimental Intracerebral Hemorrhage

(2011) Che-Feng Chang et al.   AMERICAN JOURNAL OF PATHOLOGY

PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage

(2011) Qingyi Ma et al.   ANNALS OF NEUROLOGY

Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway

(2011) Shiu Hwa Yeh et al.   NUCLEIC ACIDS RESEARCH

DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1-dependent mechanism

(2010) Donghong Zhang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Urinary 8-OHdG elevations in a partial lesion rat model of parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion

(2010) Yoichiro Kikuchi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis

(2010) Charlotte JJ van Asch et al.   LANCET NEUROLOGY

Preclinical and clinical research on inflammation after intracerebral hemorrhage

(2010) Jian Wang   PROGRESS IN NEUROBIOLOGY

Soluble Epoxide Inhibition Is Protective Against Cerebral Ischemia via Vascular and Neural Protection

(2009) Alexis N. Simpkins et al.   AMERICAN JOURNAL OF PATHOLOGY

Epoxyeicosanoid signaling in CNS function and disease

(2009) Jeffrey J. Iliff et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Post-injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury

(2008) S-F Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Soluble Epoxide Hydrolase Gene Deletion Is Protective Against Experimental Cerebral Ischemia

(2008) Wenri Zhang et al.   STROKE

Transcriptional regulation of the human soluble epoxide hydrolase gene EPHX2

(2007) Hiromasa Tanaka et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Altered Soluble Epoxide Hydrolase Gene Expression and Function and Vascular Disease Risk in the Stroke-Prone Spontaneously Hypertensive Rat

(2007) Mandi J. Corenblum et al.   HYPERTENSION