Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth
出版年份 2022 全文链接
标题
Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth
作者
关键词
-
出版物
Nature Communications
Volume 13, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-09-22
DOI
10.1038/s41467-022-33284-y
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Considerable escape of SARS-CoV-2 Omicron to antibody neutralization
- (2022) Delphine Planas et al. NATURE
- Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
- (2022) Yunlong Cao et al. NATURE
- Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2
- (2022) Lihong Liu et al. NATURE
- Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
- (2021) Paul-Albert Koenig et al. SCIENCE
- Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape
- (2021) Zhiqiang Ku et al. Nature Communications
- Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection
- (2021) Emma S. Winkler et al. CELL
- Challenges in ensuring global access to COVID-19 vaccines: production, affordability, allocation, and deployment
- (2021) Olivier J Wouters et al. LANCET
- Neutralizing Activity of BNT162b2-Elicited Serum
- (2021) Yang Liu et al. NEW ENGLAND JOURNAL OF MEDICINE
- SARS-CoV-2 spike therapeutic antibodies in the age of variants
- (2021) Alina Baum et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice
- (2021) Raoul De Gasparo et al. NATURE
- Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection
- (2021) David S. Khoury et al. NATURE MEDICINE
- BNT162b2-Elicited Neutralization against New SARS-CoV-2 Spike Variants
- (2021) Yang Liu et al. NEW ENGLAND JOURNAL OF MEDICINE
- SnapShot: SARS-CoV-2 antibodies
- (2021) David C. Montefiori et al. Cell Host & Microbe
- Principles and Current Clinical Landscape of Multispecific Antibodies against Cancer
- (2021) Mariam Elshiaty et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations
- (2021) Shane Miersch et al. JOURNAL OF MOLECULAR BIOLOGY
- BNT162b2-elicited neutralization of B.1.617 and other SARS-CoV-2 variants
- (2021) Jianying Liu et al. NATURE
- Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants
- (2021) Zhiqiang Ku et al. NATURE
- Understanding COVID-19 vaccine hesitancy
- (2021) Shingai Machingaidze et al. NATURE MEDICINE
- Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern
- (2021) Hyeseon Cho et al. Science Translational Medicine
- SARS-CoV-2 spreads through cell-to-cell transmission
- (2021) Cong Zeng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An interactive web-based dashboard to track COVID-19 in real time
- (2020) Ensheng Dong et al. LANCET INFECTIOUS DISEASES
- A Bispecific Antibody That Simultaneously Recognizes the V2- and V3-Glycan Epitopes of the HIV-1 Envelope Glycoprotein Is Broader and More Potent than Its Parental Antibodies
- (2020) Meredith E. Davis-Gardner et al. mBio
- An Infectious cDNA Clone of SARS-CoV-2
- (2020) Xuping Xie et al. Cell Host & Microbe
- Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies
- (2020) Christopher O. Barnes et al. CELL
- Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies
- (2020) Alina Baum et al. SCIENCE
- SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies
- (2020) Christopher O. Barnes et al. NATURE
- Bispecific antibodies: a mechanistic review of the pipeline
- (2019) Aran F. Labrijn et al. NATURE REVIEWS DRUG DISCOVERY
- Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity
- (2018) James J. Steinhardt et al. Nature Communications
- The making of bispecific antibodies
- (2017) Ulrich Brinkmann et al. mAbs
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity
- (2016) Yaoxing Huang et al. CELL
- The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes
- (2016) G.C.P. van Zundert et al. JOURNAL OF MOLECULAR BIOLOGY
- Intra-Spike Crosslinking Overcomes Antibody Evasion by HIV-1
- (2015) Rachel P. Galimidi et al. CELL
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- Boosting antibody developability through rational sequence optimization
- (2015) Daniel Seeliger et al. mAbs
- Towards automated crystallographic structure refinement withphenix.refine
- (2012) Pavel V. Afonine et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER
- (2012) Oliver S. Smart et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles
- (2012) Robert B. Best et al. Journal of Chemical Theory and Computation
- Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
- (2011) W. Schaefer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Integration, scaling, space-group assignment and post-refinement
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Few and Far Between: How HIV May Be Evading Antibody Avidity
- (2010) Joshua S. Klein et al. PLoS Pathogens
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now