Assessment of cholesterol homeostasis in the living human brain

The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer’s Disease

(2021) Paola Gamba et al.   Antioxidants

Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H)

(2021) Tatsuki Koike et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disturbances of brain cholesterol metabolism: A new excitotoxic process associated with status epilepticus

(2021) Aurélie Hanin et al.   NEUROBIOLOGY OF DISEASE

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

(2021) Hao Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a triazolobenzodiazepine-based PET probe for subtype-selective vasopressin 1A receptor imaging

(2021) Ahmed Haider et al.   PHARMACOLOGICAL RESEARCH

Discovery of a highly specific 18F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination

(2021) Zhiwei Xiao et al.   Acta Pharmaceutica Sinica B

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism

(2020) Eylan Yutuc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

(2020) Gill Livingston et al.   LANCET

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice

(2020) Toshiya Nishi et al.   Scientific Reports

Efavirenz as a cholesterol‐targeting drug for AD

(2020) Irina A. Pikuleva   Alzheimers & Dementia

Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and Tightrope Walk between GluN2B- and Sigma1 Receptor-Targeted PET Imaging

(2019) Ahmed Haider et al.   JOURNAL OF NUCLEAR MEDICINE

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

(2019) Rik van der Kant et al.   Cell Stem Cell

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington’s disease

(2019) Radhia Kacher et al.   BRAIN

Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases

(2019) Alexey M. Petrov et al.   Neurotherapeutics

A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model

(2019) Binbin Nie et al.   NEUROIMAGE

Plasma oxysterol profiling in children reveals 24-hydroxycholesterol as a potential marker for Autism Spectrum Disorders

(2018) S. Grayaa et al.   BIOCHIMIE

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

(2018) Johnny Habchi et al.   Nature Chemistry

24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome

(2018) Ingemar Björkhem et al.   Frontiers in Neurology

Donepezil effects on cholesterol and oxysterol plasma levels of Alzheimer’s disease patients

(2017) Alana C. Costa et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease

(2017) Scott C. Neu et al.   JAMA Neurology

Plasma sterols and depressive symptom severity in a population-based cohort

(2017) Basar Cenik et al.   PLoS One

CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

(2016) Lydie Boussicault et al.   BRAIN

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity

(2016) Kyle W. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

(2015) Fathia Djelti et al.   BRAIN

Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer’s disease: A CREDOS study

(2015) Sangha Kim et al.   COMPREHENSIVE PSYCHIATRY

Evidence for altered cholesterol metabolism in Huntington's diseasepost mortembrain tissue

(2015) Fabian Kreilaus et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease

(2013) Julius Popp et al.   BIOCHEMICAL PHARMACOLOGY

Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression

(2013) Valerio Leoni et al.   NEUROBIOLOGY OF DISEASE

Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms

(2012) A. Besga et al.   NEUROSCIENCE LETTERS

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study

(2011) Giovanni Zuliani et al.   BMC Neurology

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

(2011) Robin B. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol metabolism in Huntington disease

(2011) Joanna M. Karasinska et al.   Nature Reviews Neurology

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 2. Behavioral and cognitive changes

(2010) Roxanne Sterniczuk et al.   BRAIN RESEARCH

Structural Basis of Drug Binding to CYP46A1, an Enzyme That Controls Cholesterol Turnover in the Brain

(2010) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

(2009) Eloise Hudry et al.   MOLECULAR THERAPY

Getting a handle on Huntington's disease: the case for cholesterol

(2009) Masahisa Katsuno et al.   NATURE MEDICINE

Molecular imaging in drug development

(2008) Jürgen K. Willmann et al.   NATURE REVIEWS DRUG DISCOVERY

A population-average MRI-based atlas collection of the rhesus macaque

(2008) Donald G. McLaren et al.   NEUROIMAGE

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

(2008) N. Mast et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA