Bcl10 phosphorylation-dependent droplet-like condensation positively regulates DNA virus-induced innate immune signaling

CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells

(2022) Isis Benoit-Lizon et al.   Journal for ImmunoTherapy of Cancer

The STING phase-separator suppresses innate immune signalling

(2021) Xiaoyu Yu et al.   NATURE CELL BIOLOGY

Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases

(2020) Hong Zhang et al.   Science China-Life Sciences

cGAS-STING–mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy

(2020) Wenwen Li et al.   Science Translational Medicine

Bcl10 is required for the development and suppressive function of Foxp3+ regulatory T cells

(2019) Dandan Yang et al.   Cellular & Molecular Immunology

Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation

(2018) Daxiao Sun et al.   CELL RESEARCH

Assembly mechanism of the CARMA1–BCL10–MALT1–TRAF6 signalosome

(2018) Liron David et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

TCR Signaling: Mechanisms of Initiation and Propagation

(2018) Adam H. Courtney et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Molecular architecture and regulation of BCL10-MALT1 filaments

(2018) Florian Schlauderer et al.   Nature Communications

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Amyloid-like Self-Assembly of a Cellular Compartment

(2016) Elvan Boke et al.   CELL

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

BCL10 is recruited to sites of DNA damage to facilitate DNA double-strand break repair

(2016) Ismail Hassan Ismail et al.   CELL CYCLE

The cGAS-STING Defense Pathway and Its Counteraction by Viruses

(2016) Zhe Ma et al.   Cell Host & Microbe

CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection

(2016) Changying Jiang et al.   Cell Reports

Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1

(2016) Yuko Tsuchiya et al.   EBioMedicine

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Functional Advantages of Conserved Intrinsic Disorder in RNA-Binding Proteins

(2015) Mihaly Varadi et al.   PLoS One

Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions

(2014) Christopher J. Oldfield et al.   Annual Review of Biochemistry

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

(2013) Pu Gao et al.   CELL

Whole-genome screening identifies proteins localized to distinct nuclear bodies

(2013) Ka-wing Fong et al.   JOURNAL OF CELL BIOLOGY

Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly

(2013) Qi Qiao et al.   MOLECULAR CELL

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Selective Autophagy of the Adaptor Protein Bcl10 Modulates T Cell Receptor Activation of NF-κB

(2012) Suman Paul et al.   IMMUNITY

Regulation of NF-κB by the CARD proteins

(2012) Changying Jiang et al.   IMMUNOLOGICAL REVIEWS

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Antigen Receptor Signaling to NF- B via CARMA1, BCL10, and MALT1

(2010) M. Thome et al.   Cold Spring Harbor Perspectives in Biology

The IKK Complex, a Central Regulator of NF- B Activation

(2009) A. Israel   Cold Spring Harbor Perspectives in Biology

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS