Complexes ofTrypanosoma cruziSterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease

In VitroandIn VivoStudies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi

(2013) Maria de Nazaré Correia Soeiro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design, structure–activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi

(2013) Martine Keenan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

VNI Cures Acute and Chronic Experimental Chagas Disease

(2013) Fernando Villalta et al.   JOURNAL OF INFECTIOUS DISEASES

Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth

(2013) Grasiella Andriani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological Characterization, Structural Studies, andIn VivoActivities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib

(2012) Frederick S. Buckner et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Unusual Spectroscopic and Ligand Binding Properties of the Cytochrome P450-Flavodoxin Fusion Enzyme XplA

(2012) Soi H. Bui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease

(2012) Martine Keenan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organocatalytic, Enantioselective Synthesis of VNI: A Robust Therapeutic Development Platform for Chagas, a Neglected Tropical Disease

(2012) Mark C. Dobish et al.   ORGANIC LETTERS

CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds

(2012) Tatiana Y. Hargrove et al.   International Journal for Parasitology-Drugs and Drug Resistance

Sterol 14alpha-Demethylase (CYP51) as a Therapeutic Target for Human Trypanosomiasis and Leishmaniasis

(2011) Galina I. Lepesheva et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Triazole antifungal agents drug–drug interactions involving hepatic cytochrome P450

(2011) Paul O Gubbins   Expert Opinion on Drug Metabolism & Toxicology

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) fromLeishmania infantum

(2011) Tatiana Y. Hargrove et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol

(2011) Tatiana Y. Hargrove et al.   JOURNAL OF LIPID RESEARCH

Drug Developers Finally Take Aim at a Neglected Disease

(2011) M. Leslie   SCIENCE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural basis for conservation in the CYP51 family

(2010) Galina I. Lepesheva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Azole antimycotics and drug interactions in the perioperative period

(2010) Teijo I Saari et al.   Current Opinion in Anesthesiology

Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human PathogenTrypanosoma cruzi

(2010) Galina I. Lepesheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Human CYP51 Inhibition by Antifungal Azoles

(2010) Natallia Strushkevich et al.   JOURNAL OF MOLECULAR BIOLOGY

Chagas disease: pushing through the pipeline

(2010) Julie Clayton   NATURE

Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections

(2009) Galina I. Lepesheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Indomethacin Amides as a Novel Molecular Scaffold for TargetingTrypanosoma cruziSterol 14α-Demethylase

(2009) Mary E. Konkle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ergosterol biosynthesis and drug development for Chagas disease

(2009) Julio A Urbina   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Mecanismos de resistencia a los antifúngicos: levaduras y hongos filamentosos

(2009) Ana Espinel-Ingroff   REVISTA IBEROAMERICANA DE MICOLOGIA

CYP51: A Major Drug Target in the Cytochrome P450 Superfamily

(2008) Galina I. Lepesheva et al.   LIPIDS

Resistance to Antifungal Agents: Mechanisms and Clinical Impact

(2007) Z. A. Kanafani et al.   CLINICAL INFECTIOUS DISEASES