Comparative profiling of single-cell transcriptome reveals heterogeneity of tumor microenvironment between solid and acinar lung adenocarcinoma

Prognostic and predictive value of the newly proposed grading system of invasive pulmonary adenocarcinoma in Chinese patients: a retrospective multicohort study

(2022) Likun Hou et al.   MODERN PATHOLOGY

A lepidic gene signature predicts patient prognosis and sensitivity to immunotherapy in lung adenocarcinoma

(2022) Thinh T. Nguyen et al.   Genome Medicine

The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors

(2022) Emma R. Scaletti et al.   ChemMedChem

Targeting mitochondrial one-carbon enzyme MTHFD2 together with pemetrexed confers therapeutic advantages in lung adenocarcinoma

(2022) Juanfen Mo et al.   Cell Death Discovery

Targeting hypoxia in the tumor microenvironment: a potential strategy to improve cancer immunotherapy

(2021) Bin Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Monotherapy and Combination Therapy Using Anti‐Angiogenic Nanoagents to Fight Cancer

(2021) Pingping Liang et al.   ADVANCED MATERIALS

Insights Gained from Single-Cell Analysis of Immune Cells in the Tumor Microenvironment

(2021) Xianwen Ren et al.   Annual Review of Immunology

A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

(2021) Sijin Cheng et al.   CELL

The cancer metabolic reprogramming and immune response

(2021) Longzheng Xia et al.   Molecular Cancer

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours

(2021) Roberta Zappasodi et al.   NATURE

Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution

(2021) Yang Liu et al.   Nature Communications

Non-genetic evolution drives lung adenocarcinoma spatial heterogeneity and progression

(2021) Daniele Tavernari et al.   Cancer Discovery

The immunosuppressive and pro-tumor functions of CCL18 at the tumor microenvironment

(2021) Ana Patrícia Cardoso et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The Molecular Basis of Ubiquitin-Conjugating Enzymes (E2s) as a Potential Target for Cancer Therapy

(2021) Xiaodi Du et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-angiogenic agents — overcoming tumour endothelial cell anergy and improving immunotherapy outcomes

(2021) Zowi R. Huinen et al.   Nature Reviews Clinical Oncology

Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity

(2021) Cheryl Q. E. Lee et al.   Nature Communications

The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation

(2021) Man Shang et al.   Nature Communications

Reactive Oxygen Species (ROS): Key components in Cancer Therapies

(2021) Biswa Mohan Sahoo et al.   Anti-Cancer Agents in Medicinal Chemistry

Conserved pan-cancer microenvironment subtypes predict response to immunotherapy

(2021) Alexander Bagaev et al.   CANCER CELL

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

(2021) Justina X. Caushi et al.   NATURE

Clinical and therapeutic relevance of cancer-associated fibroblasts

(2021) Yang Chen et al.   Nature Reviews Clinical Oncology

Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy

(2021) Audrey Lequeux et al.   ONCOGENE

Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models

(2021) Amaia Martinez-Usatorre et al.   Science Translational Medicine

Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level

(2021) Yingcheng Wu et al.   Cancer Discovery

Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and transcriptional activities of ECs in CC

(2021) Chunbo Li et al.   Molecular Therapy-Nucleic Acids

Metabolic modulation of tumours with engineered bacteria for immunotherapy

(2021) Fernando P. Canale et al.   NATURE

Genomic landscape of lung adenocarcinoma in East Asians

(2020) Jianbin Chen et al.   NATURE GENETICS

Fibrosis and cancer: A strained relationship

(2020) Bram Piersma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21

(2020) Ali Hussain et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DIVERSITY AND BIOLOGY OF CANCER-ASSOCIATED FIBROBLASTS

(2020) Giulia Biffi et al.   PHYSIOLOGICAL REVIEWS

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma

(2020) Nayoung Kim et al.   Nature Communications

Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma

(2020) Michael A. Gillette et al.   CELL

The Complex Interplay between Antioxidants and ROS in Cancer

(2020) Isaac S. Harris et al.   TRENDS IN CELL BIOLOGY

Airspace Macrophages and Monocytes Exist in Transcriptionally Distinct Subsets in Healthy Adults

(2020) Kara J Mould et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The role of ubiquitination and deubiquitination in cancer metabolism

(2020) Tianshui Sun et al.   Molecular Cancer

Molecular differences across invasive lung adenocarcinoma morphological subgroups

(2020) Bo Ci et al.   Translational Lung Cancer Research

Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy

(2020) Chengcan Yang et al.   DRUG DISCOVERY TODAY

TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts

(2020) Angelo L. Grauel et al.   Nature Communications

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

(2019) Xiaoyun Li et al.   Nature Reviews Clinical Oncology

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

(2019) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

Mitochondrial MTHFD isozymes display distinct expression, regulation, and association with cancer

(2019) R. Nilsson et al.   GENE

Down‐regulation of MTHFD2 inhibits NSCLC progression by suppressing cycle‐related genes

(2019) Chang Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Functional interpretation of single cell similarity maps

(2019) David DeTomaso et al.   Nature Communications

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

UBE2S enhances the ubiquitination of p53 and exerts oncogenic activities in hepatocellular carcinoma

(2018) Ying-Hua Pan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extraction of radiomic values from lung adenocarcinoma with near-pure subtypes in the International Association for the Study of Lung Cancer/the American Thoracic Society/the European Respiratory Society (IASLC/ATS/ERS) classification

(2018) Shun-Mao Yang et al.   LUNG CANCER

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

(2018) Xinyi Guo et al.   NATURE MEDICINE

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

(2018) Nora Kory et al.   SCIENCE

Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces

(2016) M. C. Lloyd et al.   CANCER RESEARCH

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Subtype Classification of Lung Adenocarcinoma Predicts Benefit From Adjuvant Chemotherapy in Patients Undergoing Complete Resection

(2015) Ming-Sound Tsao et al.   JOURNAL OF CLINICAL ONCOLOGY

Glucose, glycolysis and lymphocyte responses

(2015) Raymond P. Donnelly et al.   MOLECULAR IMMUNOLOGY

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

T Lymphocyte–Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity

(2015) Christopher V. Carman et al.   Frontiers in Immunology

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3

(2011) Jingqi Chen et al.   CANCER CELL

Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene

(2010) F M Buffa et al.   BRITISH JOURNAL OF CANCER

Hypoxia and cell cycle regulation of the von Hippel–Lindau tumor suppressor

(2010) W Liu et al.   ONCOGENE