Novel urea-thiourea hybrids bearing 1,4-naphthoquinone moiety: Anti-inflammatory activity on mammalian macrophages by regulating intracellular PI3K pathway, and molecular docking study

Applicability of alkanet (Alkanna tinctoria) extract for the histological staining of liver tissue

(2022) Nilgun Kusculu et al.   JOURNAL OF THE INDIAN CHEMICAL SOCIETY

Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation

(2021) Monika Maciuszek et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3H)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor

(2021) Malcolm P. Huestis et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vivo Anti-inflammatory, Analgesic, and Sedative Studies of the Extract and Naphthoquinone Isolated from Diospyros kaki (Persimmon)

(2021) Saud Bawazeer et al.   ACS Omega

Synthesis and biological evaluation of naphthoquinone phenacylimidazolium derivatives

(2021) Jing Yuan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dipeptide inhibitors of the prostate specific membrane antigen (PSMA): A comparison of urea and thiourea derivatives

(2021) Jennifer D. Young et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antiproliferative screening of novel doubly modified colchicines containing urea, thiourea and guanidine moieties

(2021) Julia Krzywik et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and comparison of in vitro dual anti-infective activities of novel naphthoquinone hybrids and atovaquone

(2021) Chané Erasmus et al.   BIOORGANIC CHEMISTRY

Injectable chitosan cryogel microspheres with biocompatible properties on mammalian macrophages in vitro

(2021) Furkan Ayaz et al.   JOURNAL OF MATERIALS SCIENCE

Design, Synthesis, and Structure–Activity Relationship of N-Aryl-N′-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy

(2021) Zhipeng Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thiourea Derivatives, Simple in Structure but Efficient Enzyme Inhibitors and Mercury Sensors

(2021) Faizan Ur Rahman et al.   MOLECULES

Complexes of 1,3-Diisobutyl Thiourea with Copper(I), Zinc(II) and Mercury(II): Their Antioxidant and Antibacterial Evaluation

(2021) Adnan Shahzad et al.   Crystals

Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy

(2021) Satish Sagar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and novel synthetic approach supported with molecular docking and biological evidence for naphthoquinone-hydrazinotriazolothiadiazine analogs as potential anticancer inhibiting topoisomerase-IIB

(2020) Samy Mohamady et al.   BIOORGANIC CHEMISTRY

1,4-Naphthoquinones: Some Biological Properties and Application

(2020) Dmitry Aminin et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Naphthoquinone Derivatives with Anti-Inflammatory Activity from Mangrove-Derived Endophytic Fungus Talaromyces sp. SK-S009

(2020) Hongju Liu et al.   MOLECULES

Gold(I), Silver(I) and Copper(I) Complexes of 2,4,6-trimethylphenyl-3-benzoylthiourea; Synthesis and biological applications

(2020) Umar Ali Khan et al.   POLYHEDRON

Optimization of 5-substituted thiazolyl ureas and 6-substituted imidazopyridines as potential HIV-1 latency reversing agents

(2020) William Nguyen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study

(2020) Samir Y. Abbas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Zn, Cd and Hg complexes with unsymmetric thiourea derivatives; syntheses, free radical scavenging and enzyme inhibition essay

(2020) Faizan Ur Rahman et al.   JOURNAL OF MOLECULAR STRUCTURE

Exploration of piperazine-derived thioureas as antibacterial and anti-inflammatory agents. In vitro evaluation against clinical isolates of colistin-resistant Acinetobacter baumannii

(2020) Sarah Mazzotta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of diaryl urea derivatives as FLT3 inhibitors

(2020) Qing Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, biological properties, and acid dissociation constant of novel naphthoquinone–triazole hybrids

(2020) Yahya Nural et al.   BIOORGANIC CHEMISTRY

Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer

(2020) Md Ashraf-Uz-Zaman et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer’s disease

(2020) Eva Mezeiova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New naphthoquinone-imidazole hybrids: Synthesis, anion recognition properties, DFT studies and acid dissociation constants

(2020) Yahya Nural et al.   JOURNAL OF MOLECULAR LIQUIDS

Design and synthesis of 4-piperazinyl quinoline derived urea/thioureas for anti-breast cancer activity by a hybrid pharmacophore approach

(2019) Raja Solomon Viswas et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The role of macrophages in the resolution of inflammation

(2019) Satoshi Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Optimization of 1,3-disubstituted urea-based inhibitors of Zika virus infection

(2019) Ronik Khachatoorian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Immunomodulatory activities of zinc(II)phthalocyanine on the mammalian macrophages through p38 pathway: Potential ex vivo immunomodulatory PDT reagents

(2019) Abdulcelil Yüzer et al.   BIOORGANIC CHEMISTRY

Novel highly functionalized 1,4-naphthoquinone 2-iminothiazole hybrids: Synthesis, photophysical properties, crystal structure, DFT studies, and anti(myco)bacterial/antifungal activity

(2019) Muge Gemili et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors

(2019) Yazgı Dizdaroglu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry

(2019) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel urea and thiourea bearing thieno[3,2-d]-pyrimidines as PI3 kinase inhibitors

(2018) Naresh Varma Seelam et al.   Anti-Cancer Agents in Medicinal Chemistry

Adamantyl thioureas as soluble epoxide hydrolase inhibitors

(2018) Vladimir Burmistrov et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2-Methylacrylamide as a bioisoster of thiourea group for 1,3-dibenzylthioureido TRPV1 receptor antagonists

(2018) Seol Rin Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and molecular docking study of piperazine derivatives as potent urease inhibitors

(2018) Muhammad Taha et al.   BIOORGANIC CHEMISTRY

Synthesis, Structure Elucidation and Biological Activities of Some Novel 4(3H)-Quinazolinones as Anti-Biofilm Agents

(2018) Sevda Turk et al.   Letters in Drug Design & Discovery

Piperazine derivatives with central pharmacological activity used as therapeutic tools

(2018) Adriane F. Brito et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Novel 1,4-naphthoquinone N-aroylthioureas: Syntheses, crystal structure, anion recognition properties, DFT studies and determination of acid dissociation constants

(2018) Müge Gemili et al.   JOURNAL OF MOLECULAR LIQUIDS

Virtual screening of naphthoquinone analogs for potent inhibitors against the cancer‐signaling PI3K/AKT/mTOR pathway

(2018) Mohd Rehan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Second generation of primaquine ureas and bis-ureas as potential antimycobacterial agents

(2018) Kristina Pavić et al.   MOLECULAR DIVERSITY

Pt(II) and Ni(II) complexes of octahydropyrrolo[3,4-c]pyrrole N -benzoylthiourea derivatives: Synthesis, characterization, physical parameters and biological activity

(2017) Muge Gemili et al.   INORGANICA CHIMICA ACTA

Synthesis and anti(myco)bacterial activity of novel 5,5-diphenylpyrrolidine N-aroylthiourea derivatives and a functionalized hexahydro-1H-pyrrolo[1,2-c]imidazole

(2017) Duygu Erşen et al.   MEDICINAL CHEMISTRY RESEARCH

Piperazine derivatives for therapeutic use: a patent review (2010-present)

(2016) Anuj K. Rathi et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia

(2016) Antonia Cianciulli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

2-Amino-2,3-dihydro-1H-2λ5-[1,3,2]diazaphospholo[4,5-b]pyridin-2-one-based urea and thiourea derivatives: synthesis, molecular docking study and evaluation of anti-inflammatory and antimicrobial activities

(2016) Subba Rao Devineni et al.   MEDICINAL CHEMISTRY RESEARCH

N,N′-Disubstituted thiourea and urea derivatives: design, synthesis, docking studies and biological evaluation against nitric oxide synthase

(2016) Mariem Chayah et al.   MedChemComm

PI3K inhibitors in inflammation, autoimmunity and cancer

(2015) Anne-Katrien Stark et al.   CURRENT OPINION IN PHARMACOLOGY

Synthesis and anti-inflammatory and antimicrobial activities of some novel 2-methylquinazolin-4(3H)-one derivatives bearing urea, thiourea and sulphonamide functionalities

(2014) Ashish P. Keche et al.   Arabian Journal of Chemistry

Recent development on naphthoquinone derivatives and their therapeutic applications as anticancer agents

(2013) Vishnu Kumar Tandon et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The discovery of potential cyclin A/CDK2 inhibitors: a combination of 3D QSAR pharmacophore modeling, virtual screening, and molecular docking studies

(2013) Abdulilah Ece et al.   MEDICINAL CHEMISTRY RESEARCH

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Mechanisms of Action of Adjuvants

(2013) Sunita Awate et al.   Frontiers in Immunology

Furano-1,2-Naphthoquinone Inhibits Src and PI3K/Akt Signaling Pathways in Ca9-22 Human Oral Squamous Carcinoma Cells

(2012) Kuei-Li Lin et al.   INTEGRATIVE CANCER THERAPIES

Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors

(2012) James W. Leahy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

The functions of cytokines and their uses in toxicology

(2004) John R. Foster   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY