2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer’s disease

Characterization of the SIM-A9 cell line as a model of activated microglia in the context of neuropathic pain

(2020) Kandarp M. Dave et al.   PLoS One

Click chemistry-assisted synthesis of novel aminonaphthoquinone-1,2,3-triazole hybrids and investigation of their cytotoxicity and cancer cell cycle alterations

(2019) Maryam Gholampour et al.   BIOORGANIC CHEMISTRY

The Anti-Amyloidogenic Action of Doxycycline: A Molecular Dynamics Study on the Interaction with Aβ42

(2019) Alfonso Gautieri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Propargylamine-derived multi-target directed ligands for Alzheimer’s disease therapy

(2019) Maria do Carmo Carreiras et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells

(2018) Chang Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Critical aggregation concentration for the formation of early Amyloid-β (1–42) oligomers

(2018) Mercedes Novo et al.   Scientific Reports

Comparison of glutathione levels measured using optimized monochlorobimane assay with those from ortho-phthalaldehyde assay in intact cells

(2017) Jan Čapek et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond

(2015) Frank T Zindo et al.   Future Medicinal Chemistry

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

(2015) Sagar H. Barage et al.   NEUROPEPTIDES

Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects

(2014) Eugenie Nepovimova et al.   JOURNAL OF MEDICINAL CHEMISTRY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: Electrochemical studies on the effects of the quinoidal moiety

(2013) Emilay B.T. Diogo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Type A and B Monoamine Oxidase in Age-Related Neurodegenerative Disorders: Their Distinct Roles in Neuronal Death and Survival

(2013) Makoto Naoi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Dual Inhibitors of Monoamine Oxidase and Cholinesterase for the Treatment of Alzheimer Disease

(2013) Matilde Yanez et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Solar photochemistry: optimisation of the photo Friedel–Crafts acylation of naphthoquinones

(2013) Lorna J. Mitchell et al.   GREEN CHEMISTRY

Structure–Activity Relationship Study of Vitamin K Derivatives Yields Highly Potent Neuroprotective Agents

(2013) Benjamin J. Josey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

Methylations of Tryptophan-Modified Naphthoquinone Affect Its Inhibitory Potential toward Aβ Aggregation

(2012) Roni Scherzer-Attali et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Surface Display of a Redox Enzyme and its Site-Specific Wiring to Gold Electrodes

(2012) Liron Amir et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

(2012) Mark A. Greenough et al.   NEUROCHEMISTRY INTERNATIONAL

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

Azaanthraquinone Assembly fromN-Propargylamino Quinone via a Au(I)-Catalyzed 6-endo-digCycloisomerization

(2010) Chunhui Jiang et al.   JOURNAL OF ORGANIC CHEMISTRY

The chemistry of Alzheimer’s disease

(2009) Arvi Rauk   CHEMICAL SOCIETY REVIEWS

Comparison of blood–brain barrier permeability assays: in situ brain perfusion, MDR1-MDCKII and PAMPA-BBB

(2008) Li Di et al.   JOURNAL OF PHARMACEUTICAL SCIENCES