Synthesis and comparison of in vitro dual anti-infective activities of novel naphthoquinone hybrids and atovaquone

Inhibitory Effect of Lygodium Root on the Cytochrome P450 3A Enzyme in vitro and in vivo

(2020) Yunfang Zhou et al.   Drug Design Development and Therapy

Can CYP Inhibition Overcome Chemotherapy Resistance?

(2020) Magnus Ingelman-Sundberg et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Synthesis, trypanocidal and anti-leishmania activity of new triazole-lapachol and nor-lapachol hybrids

(2020) Mariano Walter Pertino et al.   BIOORGANIC CHEMISTRY

Effects of Naphthazarin (DHNQ) Combined with Lawsone (NQ-2-OH) or 1,4-Naphthoquinone (NQ) on the Auxin-Induced Growth of Zea mays L. Coleoptile Segments

(2019) Małgorzata Rudnicka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis and antiproliferative evaluation of some 1,4-naphthoquinone derivatives against human cervical cancer cells

(2019) Aysecik Kacmaz et al.   Open Chemistry

Click chemistry-assisted synthesis of novel aminonaphthoquinone-1,2,3-triazole hybrids and investigation of their cytotoxicity and cancer cell cycle alterations

(2019) Maryam Gholampour et al.   BIOORGANIC CHEMISTRY

The diverse mechanisms and anticancer potential of naphthoquinones

(2019) Carolina Escardó Pereyra et al.   Cancer Cell International

Microtiter Screening Reveals Oxygen-Dependent Antimicrobial Activity of Natural Products Against Mastitis-Causing Bacteria

(2019) Scott A. Ferguson et al.   Frontiers in Microbiology

Antifungal Activity of Euclea divinorum Root and Study of its Ethnobotany and Phytopharmacology

(2019) Al-Fatimi   Processes

Synthesis and Antiplasmodial Activity of 1,2,3-Triazole-Naphthoquinone Conjugates

(2019) Oramas-Royo et al.   MOLECULES

The natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II

(2019) Hye-Young Min et al.   Cell Death & Disease

Comparison of Antifungal Azole Interactions with Adult Cytochrome P450 3A4 vs. Neonatal Cytochrome P450 3A7

(2018) Malika P. Godamudunage et al.   DRUG METABOLISM AND DISPOSITION

Potential Antileishmanial Activity of a Triazole-Based Hybrid Peptide against Leishmania major

(2018) Krishnendu Maji et al.   ChemistrySelect

In vivo antileishmanial efficacy of a naphthoquinone derivate incorporated into a Pluronic® F127-based polymeric micelle system against Leishmania amazonensis infection

(2018) Débora V.C. Mendonça et al.   BIOMEDICINE & PHARMACOTHERAPY

Triazole derivatives and their anti-tubercular activity

(2017) Shu Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target Identification Studies

(2017) Colin R. Wilson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Naphthoquinones of Sinningia reitzii and Anti-inflammatory/Antinociceptive Activities of 8-Hydroxydehydrodunnione

(2017) Adson S. Soares et al.   JOURNAL OF NATURAL PRODUCTS

Assessment of the inhibition risk of shikonin on cytochrome P450 via cocktail inhibition assay

(2017) Shuowen Tang et al.   TOXICOLOGY LETTERS

Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress

(2017) Deepak Kumar Deep et al.   PLoS Neglected Tropical Diseases

Drug resistance and treatment failure in leishmaniasis: A 21st century challenge

(2017) Alicia Ponte-Sucre et al.   PLoS Neglected Tropical Diseases

Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production

(2017) José Pérez-del Palacio et al.   Frontiers in Pharmacology

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery

(2016) Krupa Naran et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plumbagin, a plant-derived naphthoquinone metabolite induces mitochondria mediated apoptosis-like cell death in Leishmania donovani: an ultrastructural and physiological study

(2016) Bhanu Priya Awasthi et al.   APOPTOSIS

Effects of juglone and lawsone on oxidative stress in maize coleoptile cells treated with IAA

(2016) Renata Kurtyka et al.   AoB Plants

Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach

(2016) Ang Chen et al.   Scientific Reports

Hit and lead criteria in drug discovery for infectious diseases of the developing world

(2015) Kei Katsuno et al.   NATURE REVIEWS DRUG DISCOVERY

Interactions between CYP3A4 and Dietary Polyphenols

(2015) Loai Basheer et al.   Oxidative Medicine and Cellular Longevity

The potential impact of coinfection on antimicrobial chemotherapy and drug resistance

(2015) Ruthie B. Birger et al.   TRENDS IN MICROBIOLOGY

Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups?

(2014) Alberto Massarotti et al.   ChemMedChem

Sequential synthesis of amino-1,4-naphthoquinone-appended triazoles and triazole-chromene hybrids and their antimycobacterial evaluation

(2014) Balasubramanian Devi Bala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Auto-induction of phase I and phase II metabolism of artemisinin in healthy Chinese subjects after oral administration of a new artemisinin-piperaquine fixed combination

(2014) Meitong Zang et al.   MALARIA JOURNAL

Antimalarial pharmacology and therapeutics of atovaquone

(2013) G. L. Nixon et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Co-infection of tuberculosis and parasitic diseases in humans: a systematic review

(2013) Xin-Xu Li et al.   Parasites & Vectors

An unexpected copper catalyzed ‘reduction’ of an arylazide to amine through the formation of a nitrene intermediate

(2013) Hanjing Peng et al.   TETRAHEDRON

1,2,3-Triazole–Heme Interactions in Cytochrome P450: Functionally Competent Triazole–Water–Heme Complexes

(2012) Kip P. Conner et al.   BIOCHEMISTRY

The Naphthoquinone Diospyrin Is an Inhibitor of DNA Gyrase with a Novel Mechanism of Action

(2012) Shantanu Karkare et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction in Water Using Cyclodextrin as a Phase Transfer Catalyst

(2012) Jung-Ah Shin et al.   JOURNAL OF ORGANIC CHEMISTRY

Validation of a simple resazurin-based promastigote assay for the routine monitoring of miltefosine susceptibility in clinical isolates of Leishmania donovani

(2012) Arpita Kulshrestha et al.   PARASITOLOGY RESEARCH

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

(2012) Jair L. Siqueira-Neto et al.   PLoS Neglected Tropical Diseases

Revisiting the General Solubility Equation: In Silico Prediction of Aqueous Solubility Incorporating the Effect of Topographical Polar Surface Area

(2011) Jogoth Ali et al.   Journal of Chemical Information and Modeling

Stereoselective anti-SN2′ Mitsunobu reaction of α-hydroxy-α-alkenylsilanes

(2010) Masato Higashino et al.   TETRAHEDRON LETTERS

Trifluoromethyl ethers – synthesis and properties of an unusual substituent

(2008) Frédéric R Leroux et al.   Beilstein Journal of Organic Chemistry

The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase

(2008) Christophe Morin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY