ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response

Dietary Choline Alleviates High-Fat Diet-Induced Hepatic Lipid Dysregulation via UPRmt Modulated by SIRT3-Mediated mtHSP70 Deacetylation

(2022) Yu-Feng Song et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systemic effects of mitochondrial stress

(2020) Raz Bar‐Ziv et al.   EMBO REPORTS

Mitochondrial sphingosine-1-phosphate lyase is essential for phosphatidylethanolamine synthesis and survival of Trypanosoma brucei

(2020) Ladan Dawoody Nejad et al.   Scientific Reports

The UPRosome – decoding novel biological outputs of IRE1α function

(2020) Hery Urra et al.   JOURNAL OF CELL SCIENCE

Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction

(2020) A. Maharaj et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation

(2020) Kim Schneider et al.   Cell Reports

Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRER Activation and Behavior in C. elegans

(2020) Neşem P. Özbey et al.   DEVELOPMENTAL CELL

Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis

(2019) Umut I. Onat et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

(2019) Amado Carreras-Sureda et al.   NATURE CELL BIOLOGY

Disruption of IRE1α through its kinase domain attenuates multiple myeloma

(2019) Jonathan M. Harnoss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mitochondria–Endoplasmic Reticulum Contacts and Their Critical Role in Aging and Age-Associated Diseases

(2019) Ornella Moltedo et al.   Frontiers in Cell and Developmental Biology

Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

(2019) Andreane Cartier et al.   SCIENCE

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

(2018) Justine Lebeau et al.   Cell Reports

PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs

(2018) Yoosik Kim et al.   MOLECULAR CELL

An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast

(2018) Katja G. Hansen et al.   SCIENCE

Sphingosine Kinase Activates the Mitochondrial Unfolded Protein Response and Is Targeted to Mitochondria by Stress

(2018) Sungjin Kim et al.   Cell Reports

The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1

(2018) Diego Acosta-Alvear et al.   eLife

ATF5 regulates β-cell survival during stress

(2017) Christine A. Juliana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting IRE1 with small molecules counteracts progression of atherosclerosis

(2017) Ozlem Tufanli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity

(2017) Takashi Matsumoto et al.   Oncogenesis

Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E −/− Mice

(2017) Petteri Rinne et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease

(2017) Alba Di Pardo et al.   Scientific Reports

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

IRE1α mediates PKR activation in response to Chlamydia trachomatis infection

(2016) Steve J. Webster et al.   MICROBES AND INFECTION

ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex

(2016) Kyungho Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER-to-mitochondria miscommunication and metabolic diseases

(2015) Camila López-Crisosto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Involvement of the IRE1α-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic Diseases

(2015) Rong Wu et al.   DNA AND CELL BIOLOGY

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

(2015) Denise N. Bronner et al.   IMMUNITY

Multiple autophosphorylations significantly enhance the endoribonuclease activity of human inositol requiring enzyme 1α

(2014) Daniel Itzhak et al.   BMC BIOCHEMISTRY

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

Emerging Roles of Mitochondria ROS in Atherosclerotic Lesions: Causation or Association?

(2014) Ying Wang et al.   Journal of Atherosclerosis and Thrombosis

LDL Receptor and ApoE Are Involved in the Clearance of ApoM-associated Sphingosine 1-Phosphate

(2014) Makoto Kurano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability

(2014) Paul E. Harrington et al.   ACS Medicinal Chemistry Letters

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells

(2013) Yuan-Li Huang et al.   CELLULAR SIGNALLING

ATF4 deficiency protects hepatocytes from oxidative stressviainhibiting CYP2E1 expression

(2013) Chunxia Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

p300-Dependent Acetylation of Activating Transcription Factor 5 Enhances C/EBP  Transactivation of C/EBP  during 3T3-L1 Differentiation

(2013) Y. Zhao et al.   MOLECULAR AND CELLULAR BIOLOGY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

(2013) Jiyung Shin et al.   Cell Reports

Gene Expression Regulation by Upstream Open Reading Frames and Human Disease

(2013) Cristina Barbosa et al.   PLoS Genetics

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial quality control: an integrated network of pathways

(2012) Fabian Fischer et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis in Liver

(2010) Meryem Bektas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

Sphingosine 1-Phosphate

(2009) G. Daum et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Synthesis of a Fluorogenic Analogue of Sphingosine-1-Phosphate and Its Use to Determine Sphingosine-1-Phosphate Lyase Activity

(2009) Carmen Bedia et al.   CHEMBIOCHEM

Signalling Pathways in the Unfolded Protein Response: Development from Yeast to Mammals

(2009) K. Mori   JOURNAL OF BIOCHEMISTRY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

(2009) Ebru Erbay et al.   NATURE MEDICINE

AAA proteases in mitochondria: diverse functions of membrane-bound proteolytic machines

(2009) Takashi Tatsuta et al.   RESEARCH IN MICROBIOLOGY

Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells

(2009) Wonsuk Yang et al.   TOXICOLOGY LETTERS

Phosphorylation of eIF2 DirectsATF5Translational Control in Response to Diverse Stress Conditions

(2008) Donghui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE