Discovery of N-benzylarylamide derivatives as novel tubulin polymerization inhibitors capable of activating the Hippo pathway
出版年份 2022 全文链接
标题
Discovery of N-benzylarylamide derivatives as novel tubulin polymerization inhibitors capable of activating the Hippo pathway
作者
关键词
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出版物
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 240, Issue -, Pages 114583
出版商
Elsevier BV
发表日期
2022-07-07
DOI
10.1016/j.ejmech.2022.114583
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- (2021) Ting Zhu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2021) Anthony Markham et al. DRUGS
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- (2021) Hyehyun Jeong et al. INVESTIGATIONAL NEW DRUGS
- A review: hippo signaling pathway promotes tumor invasion and metastasis by regulating target gene expression
- (2021) Hong-Li Li et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect
- (2021) Jianhong Yang et al. Science Advances
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- (2021) Jing Chen et al. Cancer Cell International
- Hippo pathway: Regulation, deregulation and potential therapeutic targets in cancer
- (2021) Suman Mohajan et al. CANCER LETTERS
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- (2021) Runlai Liu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- The Mechanism of Tubulin Assembly into Microtubules: Insights from Structural Studies
- (2020) Marcel Knossow et al. iScience
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- (2020) Zlata Boiarska et al. DRUG DISCOVERY TODAY
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- (2020) Virginia Spanò et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The Hippo pathway as a drug target in gastric cancer
- (2018) Yiting Qiao et al. CANCER LETTERS
- Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site
- (2018) Ling Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton
- (2018) Michel O. Steinmetz et al. TRENDS IN CELL BIOLOGY
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- The Hippo Pathway: Biology and Pathophysiology
- (2018) Shenghong Ma et al. Annual Review of Biochemistry
- Taxol®: The First Microtubule Stabilizing Agent
- (2017) Chia-Ping Yang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Combretastatin linked 1,3,4-oxadiazole conjugates as a Potent Tubulin Polymerization inhibitors
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- Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance
- (2009) E. A. Perez MOLECULAR CANCER THERAPEUTICS
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