Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy

(2019) Kinsie E Arnst et al.   MEDICINAL RESEARCH REVIEWS

Covalent modification of Cys-239 in β-tubulin by small molecules as a strategy to promote tubulin heterodimer degradation

(2019) Jianhong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tubulin inhibitors as novel anticancer agents: an overview on patents (2013-2018)

(2019) Kashif Haider et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity

(2019) Lu Niu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes

(2016) Harinath Doodhi et al.   CURRENT BIOLOGY

Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation

(2016) Andrea E. Prota et al.   JOURNAL OF MOLECULAR BIOLOGY

Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule

(2016) Jianhong Yang et al.   Nature Communications

Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A

(2014) Andrea E. Prota et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

(2014) A. E. Prota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth Arrest by the Antitumor Steroidal Lactone Withaferin A in Human Breast Cancer Cells Is Associated with Down-regulation and Covalent Binding at Cysteine 303 of β-Tubulin

(2013) Marie L. Antony et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

(2013) A. E. Prota et al.   SCIENCE

Simple Biosensor with High Selectivity and Sensitivity: Thiol-Specific Biomolecular Probing and Intracellular Imaging by AIE Fluorogen on a TLC Plate through a Thiol-Ene Click Mechanism

(2010) Yang Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

The microtubule-active antitumor compound TTI-237 has both paclitaxel-like and vincristine-like properties

(2009) Carl F. Beyer et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cevipabulin (TTI-237): Preclinical and clinical results for a novel antimicrotubule agent

(2009) S. Ayral-Kaloustian et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

TTI-237: A Novel Microtubule-Active Compound with In vivo Antitumor Activity

(2008) C. F. Beyer et al.   CANCER RESEARCH