MITA/STING-mediated antiviral immunity and autoimmunity: the evolution, mechanism, and intervention

Intervention of cGAS‒STING signaling in sterile inflammatory diseases

(2022) Ze Hong et al.   Journal of Molecular Cell Biology

Lung Inflammation in STING-Associated Vasculopathy with Onset in Infancy (SAVI)

(2022) Clémence David et al.   Cells

CDK inhibitor Palbociclib targets STING to alleviate autoinflammation

(2022) Jiani Gao et al.   EMBO REPORTS

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes

(2022) Anna Maria Sole Giordano et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy

(2022) Jared T. Hinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficiency in coatomer complex I causes aberrant activation of STING signalling

(2022) Annemarie Steiner et al.   Nature Communications

Role of the cGAS–STING pathway in systemic and organ-specific diseases

(2022) Sladjana Skopelja-Gardner et al.   Nature Reviews Nephrology

Homeostatic regulation of STING by retrograde membrane traffic to the ER

(2021) Kojiro Mukai et al.   Nature Communications

Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING

(2021) Run Fang et al.   IMMUNITY

The STING phase-separator suppresses innate immune signalling

(2021) Xiaoyu Yu et al.   NATURE CELL BIOLOGY

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections

(2021) Seoyun Yum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

(2021) Ting-Ting Chu et al.   NATURE

STING inhibitors target the cyclic dinucleotide binding pocket

(2021) Ze Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance

(2021) Tong Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

(2021) Joschka Willemsen et al.   Cell Reports

The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy

(2021) Patrick Kwabena Oduro et al.   Acta Pharmaceutica Sinica B

Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP

(2020) Vladislav Pokatayev et al.   NATURE IMMUNOLOGY

A Defect in Thymic Tolerance Causes T Cell–Mediated Autoimmunity in a Murine Model of COPA Syndrome

(2020) Zimu Deng et al.   JOURNAL OF IMMUNOLOGY

CBASS Immunity Uses CARF-Related Effectors to Sense 3′–5′- and 2′–5′-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection

(2020) Brianna Lowey et al.   CELL

Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion

(2020) Jianjun Wu et al.   IMMUNITY

A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome

(2020) Zimu Deng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

(2020) Alice Lepelley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

(2020) Chien-Hsiung Yu et al.   CELL

STING cyclic dinucleotide sensing originated in bacteria

(2020) Benjamin R. Morehouse et al.   NATURE

C9orf72 in myeloid cells suppresses STING-induced inflammation

(2020) Madelyn E. McCauley et al.   NATURE

Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients

(2020) Marie-Louise Frémond et al.   Journal of Allergy and Clinical Immunology-In Practice

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

(2019) Guijun Shang et al.   NATURE

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

(2019) Jianjun Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING-associated lung disease in mice relies on T cells but not type I interferon

(2019) Hella Luksch et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

(2019) Lauren D. Aarreberg et al.   MOLECULAR CELL

Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models

(2019) Mona Motwani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

(2019) Carina C. de Oliveira Mann et al.   Cell Reports

STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition

(2019) Sabrina L. Ergun et al.   CELL

Accumulation of cytoplasmic DNA due to ATM deficiency activates the microglial viral response system with neurotoxic consequences

(2019) Xuan Song et al.   JOURNAL OF NEUROSCIENCE

Cyclic GMP–AMP signalling protects bacteria against viral infection

(2019) Daniel Cohen et al.   NATURE

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

(2019) Shane Horsefield et al.   SCIENCE

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

(2019) Ki Wung Chung et al.   Cell Metabolism

STING-Associated Vasculopathy with Onset in Infancy in Three Children with New Clinical Aspect and Unsatisfactory Therapeutic Responses to Tofacitinib

(2019) Xiaolei Tang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases

(2019) Ming-Ming Hu et al.   Annual Review of Immunology

Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain

(2018) Yuan Liu et al.   Cell Host & Microbe

Severe combined immunodeficiency in stimulator of interferon genes (STING) V154M/wild-type mice

(2018) Delphine Bouis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function

(2018) Marina Martin et al.   Cell Reports

The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila

(2018) Akira Goto et al.   IMMUNITY

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

STING directly activates autophagy to tune the innate immune response

(2018) Dong Liu et al.   CELL DEATH AND DIFFERENTIATION

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING

(2018) Tony Siu et al.   ACS Medicinal Chemistry Letters

The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

(2018) Senlin Li et al.   Cell Reports

STING-associated vasculopathy develops independently of IRF3 in mice

(2017) James D. Warner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Enigmatic Role of C9ORF72 in Autophagy

(2017) Melissa Nassif et al.   Frontiers in Neuroscience

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs

(2016) Wei Chen et al.   PLoS Pathogens

COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis

(2015) Levi B Watkin et al.   NATURE GENETICS

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

(2014) Nadia Jeremiah et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrinsic Self-DNA Triggers Inflammatory Disease Dependent on STING

(2014) Jeonghyun Ahn et al.   JOURNAL OF IMMUNOLOGY

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

STING manifests self DNA-dependent inflammatory disease

(2012) J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE