Cell death and inflammation during obesity: “Know my methods, WAT(son)”

No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death

(2022) Ashley Weir et al.   BIOCHEMICAL JOURNAL

Leptin and Obesity: Role and Clinical Implication

(2021) Milan Obradovic et al.   Frontiers in Endocrinology

The role of RIPK3 in liver mitochondria bioenergetics and function

(2021) Tawhidul Islam et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism

(2021) Leen Catrysse et al.   Cell Reports

BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis

(2021) Hector Flores‐Romero et al.   EMBO JOURNAL

Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease

(2020) Vian Azzu et al.   GASTROENTEROLOGY

Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death

(2020) Maria C. Tanzer et al.   Cell Reports

RIPK3 orchestrates fatty acid metabolism in tumor-associated macrophages and hepatocarcinogenesis

(2020) Lei Wu et al.   Cancer Immunology Research

Absence of the Caspases 1/11 Modulates Liver Global Lipid Profile and Gut Microbiota in High-Fat-Diet-Induced Obese Mice

(2020) Lívia Pimentel de Sant'Ana et al.   Frontiers in Immunology

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

(2020) Robin Schwarzer et al.   IMMUNITY

MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis

(2020) Xiaoqin Wu et al.   JOURNAL OF HEPATOLOGY

RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease

(2020) Marta B Afonso et al.   GUT

NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet

(2020) Marina Sokolova et al.   Scientific Reports

Adipogenesis and metabolic health

(2019) Alexandra L. Ghaben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The pseudokinase MLKL regulates hepatic insulin sensitivity independently of inflammation

(2019) Haixia Xu et al.   Molecular Metabolism

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly

(2019) Kaiwen W Chen et al.   EMBO JOURNAL

Inhibition of mixed lineage kinase domain like pseudokinase decreases fat de novo synthesis and chemokine ligand expression in non‐alcoholic fatty liver disease

(2019) Waqar Khalid Saeed et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Cell Death and Inflammation – A Vital but Dangerous Liaison

(2019) Nieves Peltzer et al.   TRENDS IN IMMUNOLOGY

Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes

(2019) Jingli Lu et al.   Frontiers in Immunology

Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond

(2019) Rui Liu et al.   Frontiers in Immunology

An NF-kappaB- and IKK-Independent Function of NEMO Prevents Hepatocarcinogenesis by Suppressing Compensatory Liver Regeneration

(2019) Koppe et al.   Cancers

NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling

(2019) Xabier Unamuno et al.   Cellular & Molecular Immunology

Nlrp1b1 negatively modulates obesity-induced inflammation by promoting IL-18 production

(2019) Jonathan Salazar-León et al.   Scientific Reports

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice

(2018) Bing Xu et al.   JOURNAL OF HEPATOLOGY

Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer

(2018) Alessandro Annibaldi et al.   TRENDS IN MOLECULAR MEDICINE

Obesity, Fat Mass and Immune System: Role for Leptin

(2018) Vera Francisco et al.   Frontiers in Physiology

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

(2018) Nieves Peltzer et al.   NATURE

The obese adipose tissue microenvironment in cancer development and progression

(2018) Daniela F. Quail et al.   Nature Reviews Endocrinology

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1β on White Adipocyte Browning

(2017) Meshail Okla et al.   INFLAMMATION

Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue

(2017) Zhenjiang Liu et al.   JOURNAL OF PINEAL RESEARCH

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

(2017) Pi-Xiao Wang et al.   NATURE MEDICINE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB

(2017) Leen Catrysse et al.   TRENDS IN CELL BIOLOGY

Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue

(2017) Charles Caër et al.   Scientific Reports

RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd -Deficient Mice

(2017) Qun Zhao et al.   Cell Reports

Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity

(2016) Hiroaki Kimura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome

(2016) Andrew J. Murphy et al.   Cell Metabolism

An outline of necrosome triggers

(2016) Tom Vanden Berghe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Poly-ubiquitination in TNFR1-mediated necroptosis

(2016) Yves Dondelinger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IKKβ Is Essential for Adipocyte Survival and Adaptive Adipose Remodeling in Obesity

(2016) Se-Hyung Park et al.   DIABETES

Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues

(2016) Vanessa Pellegrinelli et al.   DIABETOLOGIA

FADD is a key regulator of lipid metabolism

(2016) Hongqin Zhuang et al.   EMBO Molecular Medicine

Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury

(2016) Sanjoy Roychowdhury et al.   HEPATOLOGY

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

(2016) Katerina Vlantis et al.   IMMUNITY

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

(2016) Silvia Alvarez-Diaz et al.   IMMUNITY

Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR−/−.Leiden mice

(2016) M C Morrison et al.   INTERNATIONAL JOURNAL OF OBESITY

Adiponectin: a versatile player of innate immunity

(2016) Yan Luo et al.   Journal of Molecular Cell Biology

The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance

(2016) Jérémie Gautheron et al.   Nature Communications

Blocking Nuclear Factor-Kappa B Protects against Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice

(2016) Tianshu Zeng et al.   PLoS One

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

(2015) Yves Dondelinger et al.   MOLECULAR CELL

Targeting the NLRP3 Inflammasome to Reduce Diet-Induced Metabolic Abnormalities in Mice

(2015) Fausto Chiazza et al.   MOLECULAR MEDICINE

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment

(2015) Andrea A. Hill et al.   Molecular Metabolism

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Adipocyte-Specific IKKβ Signaling Suppresses Adipose Tissue Inflammation through an IL-13-Dependent Paracrine Feedback Pathway

(2014) Hyokjoon Kwon et al.   Cell Reports

Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue

(2013) Nathalie Esser et al.   DIABETOLOGIA

Obesity development in caspase-1-deficient mice

(2013) H Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

(2013) Shannon M Reilly et al.   NATURE MEDICINE

Interleukin-1β Regulates Fat-Liver Crosstalk in Obesity by Auto-Paracrine Modulation of Adipose Tissue Inflammation and Expandability

(2013) Ori Nov et al.   PLoS One

Death Receptor-Ligand Systems in Cancer, Cell Death, and Inflammation

(2013) H. Walczak   Cold Spring Harbor Perspectives in Biology

Implication of inflammatory signaling pathways in obesity-induced insulin resistance

(2013) Jean-François Tanti et al.   Frontiers in Endocrinology

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Selective Insulin and Leptin Resistance in Metabolic Disorders

(2012) A. Christine Könner et al.   Cell Metabolism

Intrinsic Differences in Adipocyte Precursor Cells From Different White Fat Depots

(2012) Y. Macotela et al.   DIABETES

High-Fat Diet-Induced Adipocyte Cell Death Occurs Through a Cyclophilin D Intrinsic Signaling Pathway Independent of Adipose Tissue Inflammation

(2011) D. Feng et al.   DIABETES

The Inflammasome and Caspase-1 Activation: A New Mechanism Underlying Increased Inflammatory Activity in Human Visceral Adipose Tissue

(2011) Tim B. Koenen et al.   ENDOCRINOLOGY

Targeted Deletion of Adipocytes by Apoptosis Leads to Adipose Tissue Recruitment of Alternatively Activated M2 Macrophages

(2011) Pamela Fischer-Posovszky et al.   ENDOCRINOLOGY

Constitutive Activation of IKKβ in Adipose Tissue Prevents Diet-Induced Obesity in Mice

(2011) Ping Jiao et al.   ENDOCRINOLOGY

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

AMP-activated protein kinase: nature's energy sensor

(2011) David Carling et al.   Nature Chemical Biology

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

(2009) Shian-Huey Chiang et al.   CELL

Uncoupling of Inflammation and Insulin Resistance by NF-κB in Transgenic Mice through Elevated Energy Expenditure

(2009) Tianyi Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis

(2009) Naim Alkhouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Depot-Specific Differences in Adipogenic Progenitor Abundance and Proliferative Response to High-Fat Diet

(2009) Aaron W.B. Joe et al.   STEM CELLS

Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity

(2008) O. Osborn et al.   CYTOKINE

The Antiinflammatory Cytokine Interleukin-1 Receptor Antagonist Protects from High-Fat Diet-Induced Hyperglycemia

(2008) Nadine S. Sauter et al.   ENDOCRINOLOGY

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

(2008) I. Murano et al.   JOURNAL OF LIPID RESEARCH

Hepatic NF- B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

(2008) F. T. Wunderlich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA