The JAK-STAT pathway at 30: Much learned, much more to do

Mechanisms encoding STAT functional diversity for context-specific inflammatory responses

(2022) Samuel A Myers et al.   CURRENT OPINION IN IMMUNOLOGY

Aberrant inflammatory responses to type I interferon in STAT2 or IRF9 deficiency

(2022) Florian Gothe et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

(2022) Saedis Saevarsdottir et al.   ANNALS OF THE RHEUMATIC DISEASES

Facile discovery of surrogate cytokine agonists

(2022) Michelle Yen et al.   CELL

Type I interferon-mediated tumor immunity and its role in immunotherapy

(2022) Renren Yu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A partial form of inherited human USP18 deficiency underlies infection and inflammation

(2022) Marta Martin-Fernandez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-2 superkines by computational design

(2022) Junming Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation

(2022) Caleb R. Glassman et al.   SCIENCE

Interferons reshape the 3D conformation and accessibility of macrophage chromatin

(2022) Ekaterini Platanitis et al.   iScience

STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resists myeloablation and neoplastic expansion

(2022) Juan Li et al.   BLOOD

Aberrant type 1 immunity drives susceptibility to mucosal fungal infections

(2021) Timothy J. Break et al.   SCIENCE

Deconvoluting global cytokine signaling networks in natural killer cells

(2021) Gabriela M. Wiedemann et al.   NATURE IMMUNOLOGY

A STAT5B-CD9 axis determines self-renewal in hematopoietic and leukemic stem cells

(2021) Sebastian Kollmann et al.   BLOOD

Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation

(2021) Margherita Peron et al.   DEVELOPMENT

Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus

(2021) Sarfaraz A. Hasni et al.   Nature Communications

Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer

(2021) Sultan Alhayyani et al.   ONCOGENE

PD-L1 sustains chronic, cancer cell–intrinsic responses to type I interferon, enhancing resistance to DNA damage

(2021) HyeonJoo Cheon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JAK Inhibitor Therapy in a Child with Inherited USP18 Deficiency

(2020) Fahad Alsohime et al.   NEW ENGLAND JOURNAL OF MEDICINE

TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis

(2020) Eric Gracey et al.   JOURNAL OF CLINICAL INVESTIGATION

Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions

(2020) Marta Martin-Fernandez et al.   Cell Reports

A virus-induced conformational switch of STAT1-STAT2 dimers boosts antiviral defenses

(2020) Yuxin Wang et al.   CELL RESEARCH

Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function

(2020) Conor N. Gruber et al.   IMMUNITY

Signalling input from divergent pathways subverts B cell transformation

(2020) Lai N. Chan et al.   NATURE

Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells

(2020) Giuseppe Sciumè et al.   IMMUNITY

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

(2020) Lisa Miorin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early-onset autoimmunity associated with SOCS1 haploinsufficiency

(2020) Jérôme Hadjadj et al.   Nature Communications

SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2

(2020) Jingfang Mu et al.   Cell Discovery

Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain

(2019) James R. Burke et al.   Science Translational Medicine

Structural and functional consequences of the STAT5BN642H driver mutation

(2019) Elvin D. de Araujo et al.   Nature Communications

A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription

(2019) Ekaterini Platanitis et al.   Nature Communications

Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes

(2019) Alicia V. Zamudio et al.   MOLECULAR CELL

STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth

(2019) Chunyan Zhang et al.   Cell Metabolism

Interferon target-gene expression and epigenomic signatures in health and disease

(2019) Franck J. Barrat et al.   NATURE IMMUNOLOGY

Mimetics of Suppressor of cytokine signalling 3: novel potential therapeutics in triple breast cancer

(2018) Sara La Manna et al.   INTERNATIONAL JOURNAL OF CANCER

The MTase-like domain of chikungunya virus nsP2 inhibits the interferon response by promoting the nuclear export of STAT1

(2018) Giel P. Göertz et al.   JOURNAL OF VIROLOGY

IRF9 and unphosphorylated STAT2 cooperate with NF-κB to drive IL6 expression

(2018) Jing Nan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function

(2018) Srinivasan Rengachari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses

(2018) Lidia Avalle et al.   CELL DEATH AND DIFFERENTIATION

Transcriptional and chromatin regulation in interferon and innate antiviral gene expression

(2018) Nancy Au-Yeung et al.   CYTOKINE & GROWTH FACTOR REVIEWS

HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies

(2018) Isabelle J. Marié et al.   JOURNAL OF EXPERIMENTAL MEDICINE

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

Regulatory Networks Involving STATs, IRFs, and NFκB in Inflammation

(2018) Ekaterini Platanitis et al.   Frontiers in Immunology

JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome

(2017) Kate L. Del Bel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Enterovirus 71 suppresses interferon responses by blocking Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling through inducing karyopherin-α1 degradation

(2017) Chunyang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2

(2017) Xinyu Zhu et al.   JOURNAL OF VIROLOGY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Type I Interferon in Chronic Virus Infection and Cancer

(2017) Laura M. Snell et al.   TRENDS IN IMMUNOLOGY

Canonical and Non-Canonical Aspects of JAK–STAT Signaling: Lessons from Interferons for Cytokine Responses

(2017) Andrea Majoros et al.   Frontiers in Immunology

Parsing the Interferon Transcriptional Network and Its Disease Associations

(2016) Sara Mostafavi et al.   CELL

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

(2016) Alesha Grant et al.   Cell Host & Microbe

Negative regulation of type I IFN signaling by phosphorylation of STAT2 on T387

(2016) Yuxin Wang et al.   EMBO JOURNAL

Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency

(2016) Elena Carbognin et al.   EMBO JOURNAL

Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8 + T Cells

(2016) Sarah H. Ross et al.   IMMUNITY

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

(2016) Marije E.C. Meuwissen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection

(2016) Davide Eletto et al.   Nature Communications

ISG15 deficiency and increased viral resistance in humans but not mice

(2016) Scott D. Speer et al.   Nature Communications

STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways

(2016) Johnathan Ho et al.   PLOS BIOLOGY

Insights into Cytokine–Receptor Interactions from Cytokine Engineering

(2015) Jamie B. Spangler et al.   Annual Review of Immunology

Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity

(2015) Kiyoshi Hirahara et al.   IMMUNITY

Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins

(2015) Edmond M. Linossi et al.   IMMUNOLOGICAL REVIEWS

A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3

(2015) Daniel J. Garama et al.   MOLECULAR AND CELLULAR BIOLOGY

Super-enhancers delineate disease-associated regulatory nodes in T cells

(2015) Golnaz Vahedi et al.   NATURE

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation

(2015) Henrik M. Hammarén et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+T cells

(2015) Chi-Keung Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic profiling of the protein life cycle in response to pathogens

(2015) M. Jovanovic et al.   SCIENCE

SOCS1 Mimetics and Antagonists: A Complementary Approach to Positive and Negative Regulation of Immune Function

(2015) Chulbul M. I. Ahmed et al.   Frontiers in Immunology

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations

(2014) J. D. Milner et al.   BLOOD

Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1

(2014) Wei Xu et al.   Cell Host & Microbe

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

(2014) Xianqin Zhang et al.   NATURE

STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling

(2014) Andreas Begitt et al.   NATURE IMMUNOLOGY

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Latent Enhancers Activated by Stimulation in Differentiated Cells

(2013) Renato Ostuni et al.   CELL

IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage

(2013) HyeonJoo Cheon et al.   EMBO JOURNAL

BRD4 Coordinates Recruitment of Pause Release Factor P-TEFb and the Pausing Complex NELF/DSIF To Regulate Transcription Elongation of Interferon-Stimulated Genes

(2013) M. C. Patel et al.   MOLECULAR AND CELLULAR BIOLOGY

The Human RVB Complex Is Required for Efficient Transcription of Type I Interferon-Stimulated Genes

(2013) L. Gnatovskiy et al.   MOLECULAR AND CELLULAR BIOLOGY

Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation

(2013) Gangqing Hu et al.   NATURE IMMUNOLOGY

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

(2013) Nadia J Kershaw et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth

(2013) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional and Epigenetic Control of T Helper Cell Specification: Molecular Mechanisms Underlying Commitment and Plasticity

(2012) Yuka Kanno et al.   Annual Review of Immunology

STATs Shape the Active Enhancer Landscape of T Cell Populations

(2012) Golnaz Vahedi et al.   CELL

Acetylation modulates the STAT signaling code

(2012) Martin Wieczorek et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Critical Role of STAT5 Transcription Factor Tetramerization for Cytokine Responses and Normal Immune Function

(2012) Jian-Xin Lin et al.   IMMUNITY

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Nuclear JAK2

(2011) M. A. Dawson et al.   BLOOD

Gain-of-function humanSTAT1mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

(2011) Luyan Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2

(2011) Malay Mandal et al.   NATURE IMMUNOLOGY

Nonconventional Initiation Complex Assembly by STAT and NF-κB Transcription Factors Regulates Nitric Oxide Synthase Expression

(2010) Matthias Farlik et al.   IMMUNITY

NS5 of Dengue Virus Mediates STAT2 Binding and Degradation

(2009) J. Ashour et al.   JOURNAL OF VIROLOGY

JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin

(2009) Mark A. Dawson et al.   NATURE

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer

(2008) R. R. Weichselbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations

(2008) N. Wenta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA