ISG15 deficiency and increased viral resistance in humans but not mice

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance

(2015) Lars Ketscher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporally Controlled Reorganization of Signaling Complexes in the Plasma Membrane of Living Cells

(2015) Tim Wedeking et al.   Small

Dynamic control of type I IFN signalling by an integrated network of negative regulators

(2015) Rebecca A. Porritt et al.   TRENDS IN IMMUNOLOGY

Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15

(2014) Anja Basters et al.   FEBS Journal

Live cell micropatterning reveals the dynamics of signaling complexes at the plasma membrane

(2014) Sara Löchte et al.   JOURNAL OF CELL BIOLOGY

ISG15 Functions as an Interferon-Mediated Antiviral Effector Early in the Murine Norovirus Life Cycle

(2014) M. R. Rodriguez et al.   JOURNAL OF VIROLOGY

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

(2014) Xianqin Zhang et al.   NATURE

Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities

(2014) Anna M. Mielech et al.   VIRUS RESEARCH

Evidence for henipavirus spillover into human populations in Africa

(2014) Olivier Pernet et al.   Nature Communications

Viral OTU Deubiquitinases: A Structural and Functional Comparison

(2014) Ben A. Bailey-Elkin et al.   PLoS Pathogens

Development of a High-Throughput Assay To Measure the Neutralization Capability of Anti-Cytomegalovirus Antibodies

(2013) Thomas J. Gardner et al.   Clinical and Vaccine Immunology

Fine tuning type I interferon responses

(2013) Paul J. Hertzog et al.   CYTOKINE & GROWTH FACTOR REVIEWS

ISG15 Is Counteracted by Vaccinia Virus E3 Protein and Controls the Proinflammatory Response against Viral Infection

(2013) B. Eduardo-Correia et al.   JOURNAL OF VIROLOGY

In Vivo Bioluminescent Imaging of Influenza A Virus Infection and Characterization of Novel Cross-Protective Monoclonal Antibodies

(2013) N. S. Heaton et al.   JOURNAL OF VIROLOGY

Interferon-induced ISG15 pathway: an ongoing virus–host battle

(2013) Chen Zhao et al.   TRENDS IN MICROBIOLOGY

USP18 establishes the transcriptional and anti-proliferative interferon α/β differential

(2012) Véronique Francois-Newton et al.   BIOCHEMICAL JOURNAL

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

(2012) Seungmin Hwang et al.   Cell Host & Microbe

Mycobacterial Disease and Impaired IFN-  Immunity in Humans with Inherited ISG15 Deficiency

(2012) D. Bogunovic et al.   SCIENCE

Mechanism of Inhibition of Retrovirus Release from Cells by Interferon-Induced Gene ISG15

(2011) Z. Kuang et al.   JOURNAL OF VIROLOGY

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

(2011) Véronique François-Newton et al.   PLoS One

Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus

(2011) R. Guan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro

(2011) Jianfeng Dai et al.   Virology Journal

ISG15 Is Critical in the Control of Chikungunya Virus Infection Independent of UbE1L Mediated Conjugation

(2011) Scott W. Werneke et al.   PLoS Pathogens

The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response

(2010) R. Broering et al.   GUT

Species Specificity of the NS1 Protein of Influenza B Virus

(2010) Haripriya Sridharan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Herc5 Attenuates Influenza A Virus by Catalyzing ISGylation of Viral NS1 Protein

(2010) Y. Tang et al.   JOURNAL OF IMMUNOLOGY

Interferon-Stimulated Gene 15 and the Protein ISGylation System

(2010) Dongxian Zhang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Interferon-Induced Gene ISG15 Blocks Retrovirus Release from Cells Late in the Budding Process

(2010) A. Pincetic et al.   JOURNAL OF VIROLOGY

Species-Specific Antagonism of Host ISGylation by the Influenza B Virus NS1 Protein

(2010) G. A. Versteeg et al.   JOURNAL OF VIROLOGY

Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification

(2010) H. X. Shi et al.   MOLECULAR AND CELLULAR BIOLOGY

The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15

(2010) Larissa A. Durfee et al.   MOLECULAR CELL

ISG15 over-expression inhibits replication of the Japanese encephalitis virus in human medulloblastoma cells

(2009) Nai-Wan Hsiao et al.   ANTIVIRAL RESEARCH

Modulation of alpha interferon anti-hepatitis C virus activity by ISG15

(2009) P. K. Chua et al.   JOURNAL OF GENERAL VIROLOGY

ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response

(2008) Oxana A. Malakhova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice Lacking the ISG15 E1 Enzyme UbE1L Demonstrate Increased Susceptibility to both Mouse-Adapted and Non-Mouse-Adapted Influenza B Virus Infection

(2008) C. Lai et al.   JOURNAL OF VIROLOGY

ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity

(2008) A. Okumura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccinia Virus E3 Protein Prevents the Antiviral Action of ISG15

(2008) Susana Guerra et al.   PLoS Pathogens