BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response

(2021) Yuping Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAP1 loss augments sensitivity to BET inhibitors in cancer cells

(2021) Yu-yan Xu et al.   ACTA PHARMACOLOGICA SINICA

Immune Signatures Combined With BRCA1-Associated Protein 1 Mutations Predict Prognosis and Immunotherapy Efficacy in Clear Cell Renal Cell Carcinoma

(2021) Ze Gao et al.   Frontiers in Cell and Developmental Biology

Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development

(2020) Carlos R. Figueiredo et al.   JOURNAL OF PATHOLOGY

Targeting the HIF2–VEGF axis in renal cell carcinoma

(2020) Toni K. Choueiri et al.   NATURE MEDICINE

BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors

(2020) Anna Han et al.   ONCOGENE

BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation

(2019) Antoine Campagne et al.   Nature Communications

BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma

(2019) Raunak Shrestha et al.   Genome Medicine

BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers

(2019) Jeffim N. Kuznetsov et al.   Science Advances

Loss of BAP1 Is Associated with Upregulation of the NFkB Pathway and Increased HLA Class I Expression in Uveal Melanoma

(2019) Zahra Souri et al.   Cancers

HIF2 Inhibitor Joins the Kidney Cancer Armamentarium

(2018) William G. Kaelin   JOURNAL OF CLINICAL ONCOLOGY

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

(2018) Christopher J. Ricketts et al.   Cell Reports

OUP accepted manuscript

(2018)   JNCI-Journal of the National Cancer Institute

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Transcriptional and chromatin regulation in interferon and innate antiviral gene expression

(2018) Nancy Au-Yeung et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Design of amidobenzimidazole STING receptor agonists with systemic activity

(2018) Joshi M. Ramanjulu et al.   NATURE

Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

(2018) Lili Liao et al.   eLife

Integrating Immunotherapy Into the Management of Renal Cell Carcinoma

(2017) Matthew Zibelman et al.   Journal of the National Comprehensive Cancer Network

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

(2017) Angela Bononi et al.   NATURE

Systemic Therapy for Metastatic Renal-Cell Carcinoma

(2017) Toni K. Choueiri et al.   NEW ENGLAND JOURNAL OF MEDICINE

BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response

(2017) Fangyan Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma

(2017) Amrita M. Nargund et al.   Cell Reports

Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma

(2016) Wei Jiang et al.   PLoS One

BAP1/ASXL1 recruitment and activation for H2A deubiquitination

(2016) Danny D. Sahtoe et al.   Nature Communications

NeuCode Proteomics Reveals Bap1 Regulation of Metabolism

(2016) Joshua M. Baughman et al.   Cell Reports

Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma

(2015) Jingtao Peng et al.   CANCER LETTERS

BAP1 regulates cell cycle progression through E2F1 target genes and mediates transcriptional silencing via H2A monoubiquitination in uveal melanoma cells

(2015) Hui Pan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer

(2015) Salima Daou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitination of  -Tubulin by BAP1 Prevents Chromosome Instability in Breast Cancer Cells

(2014) R. Zarrizi et al.   CANCER RESEARCH

Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair

(2014) I. H. Ismail et al.   CANCER RESEARCH

BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma

(2013) Katie A Matatall et al.   BMC CANCER

BAP1 is phosphorylated at serine 592 in S-phase following DNA damage

(2013) Ziad M. Eletr et al.   FEBS LETTERS

Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair

(2013) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAP1 loss defines a new class of renal cell carcinoma

(2012) Samuel Peña-Llopis et al.   NATURE GENETICS

Tumours associated with BAP1 mutations

(2012) Rajmohan Murali et al.   PATHOLOGY

The VHL/HIF axis in clear cell renal carcinoma

(2012) Chuan Shen et al.   SEMINARS IN CANCER BIOLOGY

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

(2011) Ignacio Varela et al.   NATURE

Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma

(2011) Guangwu Guo et al.   NATURE GENETICS

The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and Is a Critical Regulator of Gene Expression

(2010) H. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

(2010) Johanna C. Scheuermann et al.   NATURE

BRCA1-Associated Protein-1 Is a Tumor Suppressor that Requires Deubiquitinating Activity and Nuclear Localization

(2008) K. H. Ventii et al.   CANCER RESEARCH