Article
Pharmacology & Pharmacy
Juan Pang, Huihui Xu, Xu Wang, Xu Chen, Qing Li, Qiannan Liu, Yiran You, Hanyue Zhang, Zhongliang Xu, Yimin Zhao, Yinghui Zhang, Yan Yang, Wenhua Ling
Summary: This study found that RSV can dose-dependently reduce blood cholesterol levels in mice fed with HFD or HCD, by enhancing trans-intestinal cholesterol excretion (TICE) and limiting cholesterol absorption through selective activation of intestinal LXR alpha.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Masaaki Miyata, Tomoyuki Tanaka, Kazuho Takahashi, Akihiro Funaki, Yoshimasa Sugiura
Summary: Research using animal models has shown that taurine can reduce cholesterol levels, possibly by altering bile acid composition and reducing ileal FXR signaling. This study explored the mechanisms underlying the cholesterol-lowering effect of taurine in mice, revealing its potential role in modulating FXR signaling and bile acid composition to lower cholesterol levels.
Article
Biotechnology & Applied Microbiology
Mincheol Kim, Minjee Lee, Min-Goo Kim, Hayoung Kim, Boyoung Choi, Seongsik Kim, Won-Yeong Bang, Yong-Jin Kim, Jungwoo Yang, Hyun-Jae Kang
Summary: This randomized, double-blind, placebo-controlled trial aimed to assess the efficacy of Bifidobacterium breve IDCC 4401 (BBR 4401) in lowering cholesterol levels. The results showed that BBR 4401 significantly reduced LDL-C and apolipoproteinB levels compared to the placebo group, with no significant adverse events.
FERMENTATION-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Yaping Ge, Ling Zhang, Weiliang Chen, Miao Sun, Wenbin Liu, Xiangfei Li
Summary: This study investigated the effects of resveratrol on the redox balance, cholesterol homeostasis, and bile acid metabolism of Megalobrama amblycephala fed a high-carbohydrate diet. The results showed that the high-carbohydrate diet induced redox imbalance, increased cholesterol synthesis, and decreased bile acid synthesis. Resveratrol supplementation alleviated the redox imbalance, decreased cholesterol synthesis, and increased cholesterol uptake and bile acid synthesis. Overall, resveratrol improved the cholesterol homeostasis of Megalobrama amblycephala by modulating the redox response and bile acid metabolism.
Editorial Material
Medicine, General & Internal
John T. Wilkins, Donald M. Lloyd-Jones
Summary: This article reviews different lipid-lowering therapies including traditional statins and ezetimibe, as well as new therapies like PCSK-9 inhibitors, bempedoic acid, icosapent ethyl, and inclisiran, prescribed to reduce cardiovascular risk.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Food Science & Technology
Zhi-Wei Ye, Tian-Fen Guo, Can Tang, Yue Yuan, Yi Zhao, Jun Lu, Jun-Fang Lin, Li-Qiong Guo
Summary: The cholesterol-lowering mechanisms of marine L. plantarum Lp10 were investigated, revealing that bile salt hydrolase (BSH) activity and extracellular polysaccharides (EPSs) adsorption are responsible for cholesterol reduction. Transcriptome analysis showed that EPS adsorption is the main factor for cholesterol reduction independent of bile salt influence. Additionally, co-precipitation of cholesterol and deconjugated bile acids induced by BSH1 and BSH2 played a vital role in cholesterol tolerance and reduction under stress conditions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Microbiology
Samuel M. Lancaster, Brittany Lee-McMullen, Charles Wilbur Abbott, Jeniffer V. Quijada, Daniel Hornburg, Heyjun Park, Dalia Perelman, Dylan J. Peterson, Michael Tang, Aaron Robinson, Sara Ahadi, Kevin Contrepois, Chia-Jui Hung, Melanie Ashland, Tracey McLaughlin, Anna Boonyanit, Aaron Horning, Justin L. Sonnenburg, Michael P. Snyder
Summary: Dietary fibers play a role in improving cardiovascular health, preventing metabolic disorders and cancer through their impact on the microbiome. This study examined the effects of different types of fibers on various markers, including metabolomics, lipidomics, proteomics, metagenomics, cytokine panel, and clinical measurements. Each fiber showed fiber-dependent biochemical and microbial responses. Arabinoxylan (AX) intake was associated with reduced LDL and increased bile acids, contributing to cholesterol reduction. Long-chain inulin (LCI) intake led to an increase in Bifidobacterium, but at high doses, it also caused inflammation and elevated liver enzyme levels. This study provides insights into the mechanisms of fiber-induced cholesterol reduction and the effects of individual fibers on the microbiome.
CELL HOST & MICROBE
(2022)
Article
Biochemistry & Molecular Biology
Ryoma Tagawa, Masaki Kobayashi, Misako Sakurai, Maho Yoshida, Hiroki Kaneko, Yuhei Mizunoe, Yuka Nozaki, Naoyuki Okita, Yuka Sudo, Yoshikazu Higami
Summary: Long-term feeding of taurine lowers plasma cholesterol and bile acids by suppressing the FGF21/ERK pathway and upregulating Cyp7a1 expression, promoting cholesterol metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Peichun Lin, Suhua Chen, Siyan Zhong
Summary: This study compared the chemical composition and bile acid binding ability of different fucoidans and purified fucoidans from Sargassum zhangii. The results showed that fucoidans from Sargassum zhangii had high sulfate content and excellent bile acid binding ability. Furthermore, the purified fucoidans were able to reduce cholesterol levels in HepG2 cells.
Article
Nutrition & Dietetics
Zhixin Luo, Mengqian Li, Jiachuan Yang, Jia Li, Yao Zhang, Fang Liu, Emad El-Omar, Lin Han, Ji Bian, Lan Gong, Min Wang
Summary: This study found that ferulic acid (FA) can reduce high cholesterol levels caused by a high-fat diet. It does so by increasing the excretion of bile acids in the feces. FA activates the enzyme CYP7A1 in the liver, which biosynthesizes bile acids from cholesterol. This new mechanism discovered in the study may be related to the anti-obesity and hypoglycemic effects of FA.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, Research & Experimental
Mellina S. Simoes, Ana Paula Ames-Sibin, Emanuele P. Lima, Vanesa O. Pateis, Ciomar A. Bersani-Amado, Paulo C. F. Mathias, Rosane M. Peralta, Anacharis B. Sa-Nakanishi, Livia Bracht, Adelar Bracht, Jurandir F. Comar
Summary: Resveratrol inhibited glycogen catabolism and gluconeogenesis in healthy and arthritic rat livers, with a higher sensitivity in arthritic rats. It also partially inhibited mitochondrial respiration and the activities of NADH-and succinate-oxidases. The metabolite R3G had a lower impact on gluconeogenesis but a higher impact on glycogen catabolism compared to resveratrol.
Article
Pharmacology & Pharmacy
Chunlin Li, Siyu Yu, Xiaoxiao Li, Ying Cao, Meng Li, Guang Ji, Li Zhang
Summary: The HZRG formula has been shown to alleviate non-alcoholic steatohepatitis (NASH) by improving hepatic steatosis, reducing inflammation, and modulating the bile acid profile and gut dysbiosis. It enhances fecal bile acid excretion by inhibiting bile acid transporters, and improves the intestinal environment through the modulation of tight junction proteins.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanwei Li, Fang Gu, Haotian Gu, Ping Hu, Hui-Xin Liu, Demin Cai
Summary: The study demonstrated that lithocholic acid (LCA) alleviated toxic apoptosis caused by Deoxynivalenol (DON) by regulating cholesterol metabolism and modulating the expression of key genes involved in cholesterol biosynthesis and transformation in DON-exposed cells.
Article
Multidisciplinary Sciences
Chloe Quilliam, Luciana G. Reis, Yikai Ren, Yongfeng Ai, Lynn P. Weber
Summary: In 2018, the FDA found a connection between grain-free diets and canine dilated cardiomyopathy (DCM). However, the specific ingredients and causative factors are still unclear. This study fed dogs pulse-based, grain-free diets for 28 days and found that they showed decreased macronutrient digestibility, increased fecal bile acid excretion, and reduced levels of certain amino acids and taurine, leading to sub-clinical cardiac or blood changes indicative of early DCM. The results suggest a link between pea-based diets and nutritionally-mediated DCM in dogs.
Article
Food Science & Technology
Shuyuan Zhong, Jingfang Li, Meng Wei, Zeyuan Deng, Xiaoru Liu
Summary: The enzymatic browning of phenolic compounds induced by PPO is the main cause of browning in fresh-cut plants. However, the browning products produced are usually considered non-toxic. Previous studies have found that browned lotus root extracts (BLREs) can reduce cholesterol levels in obese mice, similar to fresh lotus root extracts (FLREs). This study aimed to compare the mechanisms of FLRE and BLRE in cholesterol metabolism and determine if the main component's monomer has similar effects through in vitro experiments. The results showed that both BLRE and FLRE could reduce cholesterol and triglyceride levels in HepG2 cells.
Article
Environmental Sciences
Pengpeng Zhao, Xiaoguang Xu, Xixi Zhao, Chongyang Ai, Keyi Xu, Meixuan Li, Chunmei Jiang, Junling Shi
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Review
Biotechnology & Applied Microbiology
Rongrong Yang, Shuzheng Lei, Xiaoguang Xu, Han Jin, Hui Sun, Xixi Zhao, Bing Pang, Junling Shi
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Review
Biotechnology & Applied Microbiology
X. Xu, R. Qu, W. Wu, C. Jiang, D. Shao, J. Shi
Summary: This study compared new polyketides produced in co-culture systems and discussed the activation mechanism of polyketide synthase genes, which is important for the production of pure therapeutic polyketides and the development of functional foods. The study provided a new perspective for research on functional foods, especially those involving multiple micro-organisms.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Environmental Sciences
Xixi Zhao, Liangfu Zhou, Xiaoguang Xu, Chongyang Ai, Pengpeng Zhao, Lu Yan, Chunmei Jiang, Junling Shi
Summary: Iturin A, a cyclic lipopeptide produced by Bacillus subtilis, has the potential to remove Ag+ from water by reducing Ag+ to Ag-0 and forming AgNPs. Iturin A accelerates the formation of AgNPs compared to chain peptide (CP), leading to a faster removal of Ag+ and reduced toxicity to paddy growth.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Environmental
Xiaoguang Xu, Ying Yang, Han Jin, Bing Pang, Chunmei Jiang, Dongyan Shao, Junling Shi
Summary: A filamentous fungus was used to biosynthesize Cd0.5Zn0.5S quantum dots and gold nanoparticles in situ, forming a heterogeneous nano-photocatalyst. This strategy not only improved catalytic activity for visible light degradation but also provided a solution for nano-catalyst recovery.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Environmental
Lu Yan, Kai Han, Bing Pang, Han Jin, Xixi Zhao, Xiaoguang Xu, Chunmei Jiang, Ning Cui, Tingli Lu, Junling Shi
Summary: The newly developed hydrogel shows great potential in treating chronic wounds of diabetic patients by regulating macrophage polarization and promoting angiogenesis.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Applied
Yao Lu, Yuyang Song, Jing Zhu, Xiaoguang Xu, Bing Pang, Han Jin, Chunmei Jiang, Yanlin Liu, Junling Shi
Summary: 4-Coumaroyl-CoA ligase (Al4CL) and chalcone synthase (AlCHS) genes were identified in grape endophyte Alternaria sp. MG1, and their functions were validated in Saccharomyces cerevisiae. Co-culture of separate S. cerevisiae strains containing AlCHS and Al4CL resulted in simultaneous production of naringenin and resveratrol. Yeast strain containing Al4CL showed potential for improving wine nutrients and flavor by increasing polyphenols, anthocyanins, and other compounds.
Review
Microbiology
H. Jin, X. Xu, B. Pang, R. Yang, H. Sun, C. Jiang, D. Shao, J. Shi
Summary: This study evaluated the effects of probiotics, prebiotics, and synbiotics on non-alcoholic fatty liver disease through a network meta-analysis. The results showed that probiotics, prebiotics, and synbiotics can alleviate the disease, with probiotics being the most effective. However, the research also has limitations due to the lack of high-quality randomized trials.
BENEFICIAL MICROBES
(2021)
Article
Biotechnology & Applied Microbiology
Huixin Li, Chongyang Ai, Xixi Zhao, Bing Pang, Xiaoguang Xu, Wanqin Wu, Guanwen Liu, Chunmei Jiang, Zhongli Pan, Junling Shi
Summary: By isolating wild bacteria from sewage sludge that can remove copper ions in water, the most efficient strain Bacillus pseudomycoides C6 was identified. The properties of C6 in copper ion removal, including reaction conditions and application in oat planting, were investigated. The results showed that C6 biomass could significantly reduce copper content in oat seedlings grown in copper ion contaminated water.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Environmental Sciences
Han Jin, Muhammad Shahid Riaz Rajoka, Xiaoguang Xu, Ning Liao, Bing Pang, Lu Yan, Guanwen Liu, Hui Sun, Chunmei Jiang, Dongyan Shao, Francisco J. Barba, Junling Shi
Summary: In this study, selenium-enriched Lactobacillus rhamnosus was developed and found to efficiently protect the liver and intestinal tract from lead-induced injury.
ENVIRONMENTAL POLLUTION
(2022)
Review
Food Science & Technology
Ying Yang, Meng-Yu Ren, Xiao-Guang Xu, Yue Han, Xin Zhao, Chun-Hua Li, Zhi-Lei Zhao
Summary: Mycotoxin contamination has become a challenge in food safety testing, and the detection of multiple mycotoxins requires reliable, accurate, and high-throughput techniques. Currently available methods for detection mainly rely on chromatography, spectroscopy, and electrochemistry. This review provides an overview of the recent advances in multiple mycotoxin detection methods, discussing the principles, features, practical applications, and challenges associated with these techniques.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Crystallography
Jing Zhu, Hai Hou, Kun Li, Xiaoguang Xu, Chunmei Jiang, Dongyan Shao, Junling Shi, Dachuan Yin
Summary: In order to understand the mechanism of activity towards higher alcohols, researchers overexpressed and purified a new Geotrichum candidum GDH (GcGDH). They then crystallized the purified GcGDH and analyzed its crystal structure. The optimal reaction conditions and binding sites between GcGDH and hexanol or monosodium glutamate (MSG) were also determined. Mutating a specific amino acid residue in GcGDH resulted in a significant decrease in its catalytic efficiency.
Article
Biochemistry & Molecular Biology
Rongrong Yang, Junjun Li, Xiaoguang Xu, Keyi Xu, Junling Shi
Summary: This study demonstrated that Lactobacillus rhamnosus SHA113 and its culture supernatant have significant preventive and therapeutic effects on alcoholic gastric ulcers, mainly through mechanisms such as promoting mucus secretion, enhancing antioxidant capacity, inhibiting inflammation, and promoting ulcer healing.
Article
Biochemistry & Molecular Biology
Dongyan Shao, Yichao Di, Ziyang Lian, Bobo Zhu, Xiaoguang Xu, Dan Guo, Qingsheng Huang, Chunmei Jiang, Jie Kong, Junling Shi
Article
Biochemistry & Molecular Biology
Na Li, Bing Pang, Guanwen Liu, Xixi Zhao, Xiaoguang Xu, Chunmei Jiang, Baowei Yang, Yanlin Liu, Junling Shi