Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis
出版年份 2022 全文链接
标题
Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis
作者
关键词
-
出版物
Frontiers in Cardiovascular Medicine
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2022-06-13
DOI
10.3389/fcvm.2022.864600
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Fasting-Mimicking Diet Reduces Trimethylamine N-Oxide Levels and Improves Serum Biochemical Parameters in Healthy Volunteers
- (2022) Melita Videja et al. Nutrients
- Bifidobacterium breve and Bifidobacterium longum Attenuate Choline-Induced Plasma Trimethylamine N-Oxide Production by Modulating Gut Microbiota in Mice
- (2022) Qianqian Wang et al. Nutrients
- Author Correction: Integrated metagenomics identifies a crucial role for trimethylamine-producing Lachnoclostridium in promoting atherosclerosis
- (2022) Yuan-Yuan Cai et al. npj Biofilms and Microbiomes
- Protective effect of Ganoderma lucidum spore extract in trimethylamine‐ N ‐oxide‐induced cardiac dysfunction in rats
- (2021) Yadi Liu et al. JOURNAL OF FOOD SCIENCE
- Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice
- (2021) Wenchao Zhang et al. Scientific Reports
- Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation
- (2021) Tingting Sang et al. CARBOHYDRATE POLYMERS
- Dietary phosphatidylcholine supplementation reduces atherosclerosis in Ldlr male mice2
- (2021) Paulina Aldana-Hernández et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Metabolites and diabetes remission after weight loss
- (2021) Lydia Coulter Kwee et al. Nutrition & Diabetes
- Comparative effectiveness of team-based care with a clinical decision support system versus team-based care alone on cardiovascular risk reduction among patients with diabetes: Rationale and design of the D4C trial
- (2021) Xiulin Shi et al. AMERICAN HEART JOURNAL
- Effect of DLT-SML on Chronic Stable Angina Through Ameliorating Inflammation, Correcting Dyslipidemia, and Regulating Gut Microbiota
- (2021) Xin Zhao et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Evaluation of an 8-Week Vegan Diet on Plasma Trimethylamine-N-Oxide and Postchallenge Glucose in Adults with Dysglycemia or Obesity
- (2021) Stavroula Argyridou et al. JOURNAL OF NUTRITION
- Ligustrum Robustum Alleviates Atherosclerosis by Decreasing Serum TMAO, Modulating Gut Microbiota and Decreasing Bile acid and Cholesterol Absorption in Mice
- (2021) Sijing Liu et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Butyrate Protects Endothelial Function Through PPARδ/miR-181b Signaling
- (2021) Qinqin Tian et al. PHARMACOLOGICAL RESEARCH
- Association of the Chronotype Score with Circulating Trimethylamine N-Oxide (TMAO) Concentrations
- (2021) Luigi Barrea et al. Nutrients
- TMAO: a potential mediator of clopidogrel resistance
- (2021) Ruisong Ma et al. Scientific Reports
- Metabolic Dyslipidemia and Cardiovascular Outcomes in Type 2 Diabetes Mellitus: Findings From the Look AHEAD Study
- (2021) Arnaud D. Kaze et al. Journal of the American Heart Association
- Metabolic Signatures in Coronary Artery Disease: Results from the BioHEART-CT Study
- (2021) Stephen T. Vernon et al. Cells
- Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome
- (2021) Xingxing Li et al. npj Biofilms and Microbiomes
- Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis
- (2021) Marco Witkowski et al. CARDIOVASCULAR RESEARCH
- Metformin intervention ameliorates AS in ApoE-/- mice through restoring gut dysbiosis and anti-inflammation
- (2021) Ning Yan et al. PLoS One
- Mediterranean Diet Reduces Atherosclerosis Progression in Coronary Heart Disease: An Analysis of the CORDIOPREV Randomized Controlled Trial
- (2021) Jose Jimenez-Torres et al. STROKE
- Longitudinal Plasma Measures of Trimethylamine N‐Oxide and Risk of Atherosclerotic Cardiovascular Disease Events in Community‐Based Older Adults
- (2021) Yujin Lee et al. Journal of the American Heart Association
- Facile and label-free fluorescence strategy for evaluating the influence of bioactive ingredients on FMO3 activity via supramolecular host-guest reporter pair
- (2021) Huijuan Yu et al. BIOSENSORS & BIOELECTRONICS
- Remodelling of gut microbiota by Berberine attenuates trimethylamine N-oxide-induced platelet hyperreaction and thrombus formation
- (2021) Zulong Xie et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism
- (2020) Preeti Pathak et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease
- (2020) Nilaksh Gupta et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors
- (2020) Ina Nemet et al. CELL
- Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells
- (2020) Qi Yan Ang et al. CELL
- Effects of probiotic supplementation on serum trimethylamine-N-oxide level and gut microbiota composition in young males: a double-blinded randomized controlled trial
- (2020) Si Chen et al. EUROPEAN JOURNAL OF NUTRITION
- Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure
- (2020) Chelsea L. Organ et al. Journal of the American Heart Association
- Protein Stability in TMAO and Mixed Urea–TMAO Solutions
- (2020) Pritam Ganguly et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Reduction of intestinal trimethylamine by probiotics ameliorated lipid metabolic disorders associated with atherosclerosis
- (2020) Xi Liang et al. NUTRITION
- Gut Microbiota-Mediated Inflammation and Gut Permeability in Patients with Obesity and Colorectal Cancer
- (2020) Lidia Sánchez-Alcoholado et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Commensal Microbiota Enhances ADP-Triggered Integrin αIIbβ3 Activation and von Willebrand Factor-Mediated Platelet Deposition to Type I Collagen
- (2020) Klytaimnistra Kiouptsi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Heterogeneity of treatment effect in SPRINT by age and baseline comorbidities: The greatest impact of intensive blood pressure treatment is observed among younger patients without CKD or CVD and in older patients with CKD or CVD
- (2020) Ara H. Rostomian et al. Journal of Clinical Hypertension
- Alisma orientalis Beverage Treats Atherosclerosis by Regulating Gut Microbiota in ApoE-/- Mice
- (2020) Boran Zhu et al. Frontiers in Pharmacology
- The Enhanced Pharmacological Effects of Modified Traditional Chinese Medicine in Attenuation of Atherosclerosis Is Driven by Modulation of Gut Microbiota
- (2020) Wenyan Ji et al. Frontiers in Pharmacology
- Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD
- (2020) Yaxin Zhang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3 ) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels—Brief Report
- (2019) Diana M. Shih et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Dietary apigenin reduces induction of LOX-1 and NLRP3 expression, leukocyte adhesion and acetylated low-density lipoprotein uptake in human endothelial cells exposed to trimethylamine-N-oxide
- (2019) Kazuo Yamagata et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Dietary Choline or Trimethylamine N-oxide Supplementation Does Not Influence Atherosclerosis Development in Ldlr−/− and Apoe−/− Male Mice
- (2019) Paulina Aldana-Hernández et al. JOURNAL OF NUTRITION
- The Potential of Probiotics in the Prevention and Treatment of Atherosclerosis
- (2019) Victoria L. O'Morain et al. MOLECULAR NUTRITION & FOOD RESEARCH
- The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice
- (2019) Klytaimnistra Kiouptsi et al. mBio
- Low-grade endotoxaemia enhances artery thrombus growth via Toll-like receptor 4: implication for myocardial infarction
- (2019) Roberto Carnevale et al. EUROPEAN HEART JOURNAL
- Impact of Gut Microbiota and Diet on the Development of Atherosclerosis inApoe−/−Mice
- (2018) Annika Lindskog Jonsson et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe −/− mice
- (2018) Lin Zhu et al. ATHEROSCLEROSIS
- Trigonelline inhibits intestinal microbial metabolism of choline and its associated cardiovascular risk
- (2018) Siraj Anwar et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk
- (2018) W. Zhu et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts
- (2018) Ramón Estruch et al. NEW ENGLAND JOURNAL OF MEDICINE
- Lactobacillus plantarum ZDY04 exhibits strain-specific property of lowering-TMAO via modulation of gut microbiota in mice
- (2018) Liang Qiu et al. Food & Function
- Effect of Vegan Fecal Microbiota Transplantation on Carnitine‐ and Choline‐Derived Trimethylamine‐N‐Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome
- (2018) Loek P. Smits et al. Journal of the American Heart Association
- Berberine treatment reduces atherosclerosis by mediating gut microbiota in apoE-/- mice
- (2018) Yafei Shi et al. BIOMEDICINE & PHARMACOTHERAPY
- Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential
- (2018) Adam B. Roberts et al. NATURE MEDICINE
- Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential
- (2018) Sarah M. Skye et al. CIRCULATION RESEARCH
- Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism
- (2018) Lin Ding et al. Lipids in Health and Disease
- Trimethylamine N-oxide (TMAO), Mediterranean Diet and Nutrition in Healthy, Normal-weight Subjects: Is It Also A Matter Of Gender?
- (2018) Luigi Barrea et al. NUTRITION
- Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model
- (2018) Kazuyuki Kasahara et al. Nature Microbiology
- Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
- (2017) Hao Wu et al. NATURE MEDICINE
- Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway
- (2017) Ming‐liang Chen et al. Journal of the American Heart Association
- Uncovering the trimethylamine-producing bacteria of the human gut microbiota
- (2017) Silke Rath et al. Microbiome
- Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine
- (2017) Chongliang Gao et al. Scientific Reports
- Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
- (2016) Weifei Zhu et al. CELL
- Outline of the report on cardiovascular diseases in China, 2014
- (2016) Chen Weiwei et al. EUROPEAN HEART JOURNAL SUPPLEMENTS
- Oral butyrate reduces oxidative stress in atherosclerotic lesion sites by a mechanism involving NADPH oxidase down-regulation in endothelial cells
- (2016) Edenil C. Aguilar et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Effect of Trimethylamine N-Oxide on Interfacial Electrostatics at Phospholipid Monolayer–Water Interfaces and Its Relevance to Cardiovascular Disease
- (2016) Jahur A. Mondal Journal of Physical Chemistry Letters
- Role of gut microbiota in atherosclerosis
- (2016) Annika Lindskog Jonsson et al. Nature Reviews Cardiology
- Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota
- (2016) Ming-liang Chen et al. mBio
- Microbiota‐Dependent Metabolite Trimethylamine N‐Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA)
- (2016) Katie A. Meyer et al. Journal of the American Heart Association
- Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB
- (2016) Marcus M. Seldin et al. Journal of the American Heart Association
- Effects of egg ingestion on endothelial function in adults with coronary artery disease: A randomized, controlled, crossover trial
- (2015) David L. Katz et al. AMERICAN HEART JOURNAL
- The Mediterranean Diet, its Components, and Cardiovascular Disease
- (2015) R. Jay Widmer et al. AMERICAN JOURNAL OF MEDICINE
- Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis
- (2015) Zeneng Wang et al. CELL
- Intestinal Microbiota Metabolism and Atherosclerosis
- (2015) Shu-Yang Zhang et al. CHINESE MEDICAL JOURNAL
- High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome
- (2015) Francesca De Filippis et al. GUT
- Trimethylamine-N-Oxide Treatment Induces Changes in the ATP-Binding Cassette Transporter A1 and Scavenger Receptor A1 in Murine Macrophage J774A.1 cells
- (2015) Abbas Mohammadi et al. INFLAMMATION
- TMAO: A small molecule of great expectations
- (2015) Marcin Ufnal et al. NUTRITION
- Probiotic supplementation and trimethylamine-N-oxide production following a high-fat diet
- (2015) Nabil E. Boutagy et al. Obesity
- Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide
- (2015) Kymberleigh A. Romano et al. mBio
- Characterization and Detection of a Widely Distributed Gene Cluster That Predicts Anaerobic Choline Utilization by Human Gut Bacteria
- (2015) Ana Martínez-del Campo et al. mBio
- Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry
- (2014) Zeneng Wang et al. ANALYTICAL BIOCHEMISTRY
- γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L -Carnitine to TMAO
- (2014) Robert A. Koeth et al. Cell Metabolism
- Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide
- (2014) Z. Wang et al. EUROPEAN HEART JOURNAL
- Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation
- (2014) Jill C. Gregory et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis
- (2014) Diana M. Shih et al. JOURNAL OF LIPID RESEARCH
- Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation
- (2014) Janis Kuka et al. LIFE SCIENCES
- Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation
- (2014) E.C. Aguilar et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Fish consumption and its possible preventive role on the development and prevalence of metabolic syndrome - a systematic review
- (2014) Christine Tørris et al. Diabetology & Metabolic Syndrome
- Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
- (2013) Robert A Koeth et al. NATURE MEDICINE
- Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
- (2013) W.H. Wilson Tang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
- (2012) S. Craciun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Absence of Microbiota (Germ-Free Conditions) Accelerates the Atherosclerosis in ApoE-Deficient Mice Fed Standard Low Cholesterol Diet
- (2011) Renata Stepankova et al. Journal of Atherosclerosis and Thrombosis
- Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
- (2011) Zeneng Wang et al. NATURE
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