Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism
出版年份 2020 全文链接
标题
Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism
作者
关键词
-
出版物
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Volume 318, Issue 6, Pages H1474-H1486
出版商
American Physiological Society
发表日期
2020-04-25
DOI
10.1152/ajpheart.00584.2019
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Immunity, microbiota and kidney disease
- (2019) Felix Knauf et al. Nature Reviews Nephrology
- Quantification of bile acids: a mass spectrometry platform for studying gut microbe connection to metabolic diseases
- (2019) Ibrahim Choucair et al. JOURNAL OF LIPID RESEARCH
- Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk
- (2018) W. Zhu et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- The gut microbiota influences anticancer immunosurveillance and general health
- (2018) Bertrand Routy et al. Nature Reviews Clinical Oncology
- Microbial modulation of cardiovascular disease
- (2018) J. Mark Brown et al. NATURE REVIEWS MICROBIOLOGY
- A selective gut bacterial bile salt hydrolase alters host metabolism
- (2018) Lina Yao et al. eLife
- Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential
- (2018) Adam B. Roberts et al. NATURE MEDICINE
- Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential
- (2018) Sarah M. Skye et al. CIRCULATION RESEARCH
- Microbial impact on cholesterol and bile acid metabolism: current status and future prospects
- (2018) Aicha Kriaa et al. JOURNAL OF LIPID RESEARCH
- Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism
- (2018) Lin Ding et al. Lipids in Health and Disease
- Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases
- (2018) José E. Belizário et al. MEDIATORS OF INFLAMMATION
- Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
- (2017) Shabnam Shalapour et al. NATURE
- A communal catalogue reveals Earth’s multiscale microbial diversity
- (2017) Luke R. Thompson et al. NATURE
- Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
- (2017) Wei Jia et al. Nature Reviews Gastroenterology & Hepatology
- The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue
- (2017) Rebecca C. Schugar et al. Cell Reports
- Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
- (2016) Weifei Zhu et al. CELL
- Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism
- (2016) Annika Wahlström et al. Cell Metabolism
- DADA2: High-resolution sample inference from Illumina amplicon data
- (2016) Benjamin J Callahan et al. NATURE METHODS
- Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota
- (2016) Ming-liang Chen et al. mBio
- An Integrated Metabolomic and Microbiome Analysis Identified Specific Gut Microbiota Associated with Fecal Cholesterol and Coprostanol in Clostridium difficile Infection
- (2016) Vijay C. Antharam et al. PLoS One
- The Gut Microbial Endocrine Organ: Bacterially Derived Signals Driving Cardiometabolic Diseases
- (2015) J. Mark Brown et al. Annual Review of Medicine
- Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis
- (2015) Zeneng Wang et al. CELL
- Short-chain fatty acids in control of body weight and insulin sensitivity
- (2015) Emanuel E. Canfora et al. Nature Reviews Endocrinology
- Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
- (2015) Ji Miao et al. Nature Communications
- The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance
- (2015) Manya Warrier et al. Cell Reports
- Characterization of Choline Trimethylamine-Lyase Expands the Chemistry of Glycyl Radical Enzymes
- (2014) Smaranda Craciun et al. ACS Chemical Biology
- Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry
- (2014) Zeneng Wang et al. ANALYTICAL BIOCHEMISTRY
- Microbial Modulation of Insulin Sensitivity
- (2014) Muhammad Tanweer Khan et al. Cell Metabolism
- γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L -Carnitine to TMAO
- (2014) Robert A. Koeth et al. Cell Metabolism
- Cholesterol Esters (CE) Derived From Hepatic Sterol O-Acyltransferase 2 (SOAT2) Are Associated With More Atherosclerosis Than CE From Intestinal SOAT2
- (2014) Jun Zhang et al. CIRCULATION RESEARCH
- Interactions Between the Intestinal Microbiome and Liver Diseases
- (2014) Bernd Schnabl et al. GASTROENTEROLOGY
- Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation
- (2014) Jill C. Gregory et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis
- (2014) Diana M. Shih et al. JOURNAL OF LIPID RESEARCH
- Waste Not, Want Not: Why Rarefying Microbiome Data Is Inadmissible
- (2014) Paul J. McMurdie et al. PLoS Computational Biology
- Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist
- (2013) Sama I. Sayin et al. Cell Metabolism
- Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation
- (2013) Brian J. Bennett et al. Cell Metabolism
- Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
- (2013) Robert A Koeth et al. NATURE MEDICINE
- Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
- (2013) W.H. Wilson Tang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
- (2013) V. K. Ridaura et al. SCIENCE
- Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood
- (2012) Jun Zhang et al. JOURNAL OF LIPID RESEARCH
- Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
- (2012) Jorge Henao-Mejia et al. NATURE
- Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
- (2012) S. Craciun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
- (2011) Zeneng Wang et al. NATURE
- Discovering the false discovery rate
- (2010) Yoav Benjamini JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY
- QIIME allows analysis of high-throughput community sequencing data
- (2010) J Gregory Caporaso et al. NATURE METHODS
- Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome
- (2008) Peter J. Turnbaugh et al. Cell Host & Microbe
- A core gut microbiome in obese and lean twins
- (2008) Peter J. Turnbaugh et al. NATURE
- Innate immunity and intestinal microbiota in the development of Type 1 diabetes
- (2008) Li Wen et al. NATURE
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started