Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy

Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery

(2022) Tomoyuki Hatano et al.   Nature Communications

Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells

(2021) Kazue Terasawa et al.   Autophagy

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

(2021) Benjamin Caballero et al.   Nature Communications

Bioinformatic and Functional Characterization of Hsp70s in Myxococcus xanthus

(2021) Zhuo Pan et al.   mSphere

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

The two-domain architecture of LAMP2A regulates its interaction with Hsc70

(2021) Yuta Ikami et al.   EXPERIMENTAL CELL RESEARCH

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

TORC1 regulates vacuole membrane composition through ubiquitin- and ESCRT-dependent microautophagy

(2020) Xi Yang et al.   JOURNAL OF CELL BIOLOGY

Chaperone-Mediated Autophagy in the light of evolution: insight from fish

(2020) Laury Lescat et al.   MOLECULAR BIOLOGY AND EVOLUTION

Differential activation of eMI by distinct forms of cellular stress

(2020) Ana Mesquita et al.   Autophagy

Microautophagy – distinct molecular mechanisms handle cargoes of many sizes

(2020) Sebastian Schuck   JOURNAL OF CELL SCIENCE

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

(2019) Philipp Kirchner et al.   PLOS BIOLOGY

HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates

(2019) Bonam et al.   Cells

Molecular evolution of autophagy rate-limiting factor LAMP2 in placental mammals

(2019) Zahra Jalali et al.   GENE

CMA restricted to mammals and birds: myth or reality?

(2018) Laury Lescat et al.   Autophagy

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals

(2018) Kyle Hess et al.   Scientific Reports

The Divergent Genomes of Teleosts

(2018) Vydianathan Ravi et al.   Annual Review of Animal Biosciences

LAMP-2B regulates human cardiomyocyte function by mediating autophagosome–lysosome fusion

(2018) Congwu Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylation of translationally controlled tumor protein promotes its degradation through chaperone-mediated autophagy

(2017) Anne Bonhoure et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone

(2017) Kumsal Tekirdag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective endosomal microautophagy is starvation-inducible in Drosophila

(2016) Anindita Mukherjee et al.   Autophagy

Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes

(2016) Kazue Terasawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database

(2016) Jeremy Pasquier et al.   BMC GENOMICS

Cellular proteostasis: degradation of misfolded proteins by lysosomes

(2016) M. P. Jackson et al.   Essays in Biochemistry

Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy

(2016) Kateryna Morozova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ESCRTs Cooperate with a Selective Autophagy Receptor to Mediate Vacuolar Targeting of Soluble Cargos

(2015) Xiao-Man Liu et al.   MOLECULAR CELL

Complex archaea that bridge the gap between prokaryotes and eukaryotes

(2015) Anja Spang et al.   NATURE

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy

(2015) Valerie Uytterhoeven et al.   NEURON

The Critical Roles of HSC70 in Physiological and Pathological Processes

(2014) Yi Liao et al.   CURRENT PHARMACEUTICAL DESIGN

Structure of Transmembrane Domain of Lysosome-associated Membrane Protein Type 2a (LAMP-2A) Reveals Key Features for Substrate Specificity in Chaperone-mediated Autophagy

(2014) Ashok K. Rout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery

(2014) S. Schuck et al.   JOURNAL OF CELL SCIENCE

Discovery of a novel type of autophagy targeting RNA

(2013) Yuuki Fujiwara et al.   Autophagy

HSPA8/HSC70 chaperone protein

(2013) François Stricher et al.   Autophagy

Direct uptake and degradation of DNA by lysosomes

(2013) Yuuki Fujiwara et al.   Autophagy

Convergent evolution of heat-inducibility during subfunctionalization of the Hsp70 gene family

(2013) Sascha Krenek et al.   BMC EVOLUTIONARY BIOLOGY

Lipid droplet autophagy in the yeast Saccharomyces cerevisiae

(2013) Tim van Zutphen et al.   MOLECULAR BIOLOGY OF THE CELL

Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx

(2012) Sonja Wilke et al.   BMC BIOLOGY

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

Identification of Regulators of Chaperone-Mediated Autophagy

(2010) Urmi Bandyopadhyay et al.   MOLECULAR CELL

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Evolution of the Multivesicular Body ESCRT Machinery; Retention Across the Eukaryotic Lineage

(2008) Ka Fai Leung et al.   TRAFFIC