HSPA8/HSC70 chaperone protein

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau

(2013) Jose Abisambra et al.   BIOLOGICAL PSYCHIATRY

Allostery in Disease and in Drug Discovery

(2013) Ruth Nussinov et al.   CELL

Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy

(2013) Anna Ulbricht et al.   CURRENT BIOLOGY

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

(2013) Ruifeng Qi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lupuzor/P140 peptide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled phase IIb clinical trial

(2012) Robert Zimmer et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of HSP70: A challenging anti-cancer strategy

(2012) Anastasia R. Goloudina et al.   CANCER LETTERS

An Interdomain Energetic Tug-of-War Creates the Allosterically Active State in Hsp70 Molecular Chaperones

(2012) Anastasia Zhuravleva et al.   CELL

Peptide-based approaches to treat lupus and other autoimmune diseases

(2012) Nicolas Schall et al.   JOURNAL OF AUTOIMMUNITY

The C-terminal Helices of Heat Shock Protein 70 Are Essential for J-domain Binding and ATPase Activation

(2012) Xue-Chao Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of DnaK Protein Complexed with Nucleotide Exchange Factor GrpE in DnaK Chaperone System

(2012) Ching-Chung Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic lethal interactions in yeast reveal functional roles of J protein co-chaperones

(2012) Anne T. Gillies et al.   Molecular BioSystems

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

(2012) Adrienne M Wang et al.   Nature Chemical Biology

Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy

(2012) Jaakko Sarparanta et al.   NATURE GENETICS

Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential

(2012) Tuoen Liu et al.   PHARMACOLOGY & THERAPEUTICS

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Membrane Protein Insertion at the Endoplasmic Reticulum

(2011) Sichen Shao et al.   Annual Review of Cell and Developmental Biology

Molecular machinery of macroautophagy and its deregulation in diseases

(2011) Alan S.L. Wong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chemical Screens against a Reconstituted Multiprotein Complex: Myricetin Blocks DnaJ Regulation of DnaK through an Allosteric Mechanism

(2011) Lyra Chang et al.   CHEMISTRY & BIOLOGY

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

Differential expression of HSPA1 and HSPA2 proteins in human tissues; tissue microarray-based immunohistochemical study

(2011) Dorota Scieglinska et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Loss of nuclear pro–IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma

(2011) Clara Curiel-Lewandrowski et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity

(2011) Alba T. Macias et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones

(2011) Aikaterini Rousaki et al.   JOURNAL OF MOLECULAR BIOLOGY

The Chaperone Network Connected to Human Ribosome-Associated Complex

(2011) H. Jaiswal et al.   MOLECULAR AND CELLULAR BIOLOGY

HSP70 Inhibition by the Small-Molecule 2-Phenylethynesulfonamide Impairs Protein Clearance Pathways in Tumor Cells

(2011) J. I.-J. Leu et al.   MOLECULAR CANCER RESEARCH

Mechanics of Hsp70 chaperones enables differential interaction with client proteins

(2011) Rainer Schlecht et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heat shock protein 70 kDa chaperone/DnaJ cochaperone complex employs an unusual dynamic interface

(2011) A. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones

(2011) A. Zhuravleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical and structural studies on the high affinity of Hsp70 for ADP

(2011) Akihiko Arakawa et al.   PROTEIN SCIENCE

Binding of a Small Molecule at a Protein–Protein Interface Regulates the Chaperone Activity of Hsp70–Hsp40

(2010) Susanne Wisén et al.   ACS Chemical Biology

HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus

(2010) N. Page et al.   ANNALS OF THE RHEUMATIC DISEASES

Secretion of the heat shock proteins HSP70 and HSC70 by baby hamster kidney (BHK-21) cells

(2010) Yulia Evdokimovskaya et al.   CELL BIOLOGY INTERNATIONAL

Circulating antibodies to heat-shock protein 60 in Crohn's disease and ulcerative colitis

(2010) T. R. J. STEVENS et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

Kinesin-1/Hsc70-dependent mechanism of slow axonal transport and its relation to fast axonal transport

(2010) Sumio Terada et al.   EMBO JOURNAL

Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target

(2010) Christopher G. Evans et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone

(2010) Koyeli Mapa et al.   MOLECULAR CELL

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78

(2010) Magdalena Wisniewska et al.   PLoS One

Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody

(2010) S. Stangl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topology and dynamics of the 10 kDa C-terminal domain of DnaK in solution

(2010) Eric B. Bertelsen et al.   PROTEIN SCIENCE

The C-Terminal BAG Domain of BAG5 Induces Conformational Changes of the Hsp70 Nucleotide- Binding Domain for ADP-ATP Exchange

(2010) Akihiko Arakawa et al.   STRUCTURE

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

(2009) Andrew J. Massey et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Electrostatic Interactions of Hsp-organizing Protein Tetratricopeptide Domains with Hsp70 and Hsp90

(2009) Tommi Kajander et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat shock proteins and immune system

(2009) Min-Fu Tsan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design†

(2009) Douglas S. Williamson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allostery in Hsp70 Chaperones Is Transduced by Subdomain Rotations

(2009) Akash Bhattacharya et al.   JOURNAL OF MOLECULAR BIOLOGY

Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

(2009) U. K. Jinwal et al.   JOURNAL OF NEUROSCIENCE

Heat shock cognate protein 70 controls Borna disease virus replication via interaction with the viral non-structural protein X

(2009) Yohei Hayashi et al.   MICROBES AND INFECTION

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells

(2009) P Nirdé et al.   ONCOGENE

The Spliceosomal Phosphopeptide P140 Controls the Lupus Disease by Interacting with the HSC70 Protein and via a Mechanism Mediated by γδ T Cells

(2009) Nicolas Page et al.   PLoS One

Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS

(2009) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of small molecules that modify the protein folding activity of heat shock protein 70

(2008) Susanne Wisén et al.   ANALYTICAL BIOCHEMISTRY

Spliceosomal peptide P140 for immunotherapy of systemic lupus erythematosus: Results of an early phase II clinical trial

(2008) Sylviane Muller et al.   ARTHRITIS AND RHEUMATISM

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

(2008) Marissa V. Powers et al.   CANCER CELL

Structural Basis for the Cooperation of Hsp70 and Hsp110 Chaperones in Protein Folding

(2008) Sigrun Polier et al.   CELL

Polyamine compound deoxyspergualin inhibits heat shock protein-induced activation of immature dendritic cells

(2008) Atsushi Sugawara et al.   CELL STRESS & CHAPERONES

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

The BAG proteins: a ubiquitous family of chaperone regulators

(2008) M. Kabbage et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining Conformation

(2008) Yi-Wei Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Precursor-specific Role for Hsp40/Hsc70 during Tail-anchored Protein Integration at the Endoplasmic Reticulum

(2008) Catherine Rabu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From hatching to dispatching: the multiple cellular roles of the Hsp70 molecular chaperone machinery

(2008) Eirini Meimaridou et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Disruption of the association of 73 kDa heat shock cognate protein with transporters associated with antigen processing (TAP) decreases TAP-dependent translocation of antigenic peptides into the endoplasmic reticulum

(2008) Kenjiro Kamiguchi et al.   MICROBIOLOGY AND IMMUNOLOGY

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of the Hsp110:Hsc70 Nucleotide Exchange Machine

(2008) Jonathan P. Schuermann et al.   MOLECULAR CELL

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

(2008) Zhen Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK

(2007) Lyra Chang et al.   ANALYTICAL BIOCHEMISTRY

Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase

(2007) Susanne Wisén et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS