Asymmetric Proton Transfer Catalysis by Stereocomplementary Old Yellow Enzymes for C═C Bond Isomerization Reaction

Enzymatic Δ1-Dehydrogenation of 3-Ketosteroids—Reconciliation of Kinetic Isotope Effects with the Reaction Mechanism

(2021) Michał Glanowski et al.   ACS Catalysis

From Waste to Value—Direct Utilization of α-Angelica Lactone as a Nonconventional Irreversible Acylating Agent in a Chromatography-Free Lipase-Catalyzed KR Approach toward sec-Alcohols

(2021) Marcin Poterała et al.   ACS Sustainable Chemistry & Engineering

Two new ene-reductases from photosynthetic extremophiles enlarge the panel of old yellow enzymes: CtOYE and GsOYE

(2020) Marina Simona Robescu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Emerging strategies for expanding the toolbox of enzymes in biocatalysis

(2020) Braddock A. Sandoval et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

High-Efficiency Biocatalytic Conversion of Thebaine to Codeine

(2020) Xu Li et al.   ACS Omega

Photoenzymatic enantioselective intermolecular radical hydroalkylation

(2020) Xiaoqiang Huang et al.   NATURE

Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins

(2020) Claire G. Page et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy

(2019) Mehran Dastmalchi et al.   Nature Chemical Biology

Photoenzymatic Catalysis Enables Radical-Mediated Ketone Reduction in Ene-Reductases

(2019) Braddock A. Sandoval et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Broadening the Scope of Biocatalysis in Sustainable Organic Synthesis

(2019) Roger A. Sheldon et al.   ChemSusChem

Photoexcitation of flavoenzymes enables a stereoselective radical cyclization

(2019) Kyle F. Biegasiewicz et al.   SCIENCE

Lewis Pair-mediated Selective Dimerization and Polymerization of Lignocellulose-based β-Angelica Lactone to Biofuel and Acrylic Bioplastic

(2019) Xiao-Jun Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases

(2018) Kathrin Heckenbichler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery, Characterization, Engineering, and Applications of Ene-Reductases for Industrial Biocatalysis

(2018) Helen S. Toogood et al.   ACS Catalysis

Enantioselective Hydrogen Atom Transfer: Discovery of Catalytic Promiscuity in Flavin-Dependent ‘Ene’-Reductases

(2017) Braddock A. Sandoval et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Old Yellow Enzyme-Catalysed Asymmetric Hydrogenation: Linking Family Roots with Improved Catalysis

(2017) Anika Scholtissek et al.   Catalysts

Characterization of the Old Yellow Enzyme Homolog from Bacillus subtilis (YqjM)

(2017) Milja Pesic et al.   ChemistrySelect

Ene Reductase Enzymes for the Aromatisation of Tetralones and Cyclohexenones to Naphthols and Phenols

(2016) Paul P. Kelly et al.   ADVANCED SYNTHESIS & CATALYSIS

Sequential Enzymatic Conversion of α-Angelica Lactone to γ-Valerolactone through Hydride-Independent C=C Bond Isomerization

(2016) Nikolaus G. Turrini et al.   ChemSusChem

Identification of fungal ene-reductase activity by means of a functional screening

(2015) Alice Romagnolo et al.   Fungal Biology

Catalytic upgrading of α-angelica lactone to levulinic acid esters under mild conditions over heterogeneous catalysts

(2015) Mohammad G. Al-Shaal et al.   Catalysis Science & Technology

Functional characterization and stability improvement of a ‘thermophilic-like’ ene-reductase from Rhodococcus opacus 1CP

(2015) Anika Riedel et al.   Frontiers in Microbiology

Squalene hopene cyclases are protonases for stereoselective Brønsted acid catalysis

(2014) Stephan C Hammer et al.   Nature Chemical Biology

Comprehensive genome-wide analysis reveals different classes of enigmatic old yellow enzyme in fungi

(2014) Shadab Nizam et al.   Scientific Reports

Heterologous expression and characterization of the ene-reductases from Deinococcus radiodurans and Ralstonia metallidurans

(2013) S. Litthauer et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Mechanism and Selectivity of Bioinspired Cinchona Alkaloid Derivatives Catalyzed Asymmetric Olefin Isomerization: A Computational Study

(2013) Xiao-Song Xue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unusual CC Bond Isomerization of an α,β-Unsaturated γ-Butyrolactone Catalysed by Flavoproteins from the Old Yellow Enzyme Family

(2012) Katharina Durchschein et al.   CHEMBIOCHEM

Asymmetric Approach toward Chiral Cyclohex-2-enones from Anisoles via an Enantioselective Isomerization by a New Chiral Diamine Catalyst

(2012) Jung Hwa Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocatalytic Promiscuity

(2011) Maria Svedendahl Humble et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Olefin Isomerization of Butenolides via Proton Transfer Catalysis by an Organic Molecule

(2011) Yongwei Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Biocatalytic Reductions and Chemical Versatility of the Old Yellow Enzyme Family of Flavoprotein Oxidoreductases

(2010) Helen S. Toogood et al.   ChemCatChem

Direct Asymmetric Allylic Alkylation of Butenolides with Morita−Baylis−Hillman Carbonates

(2010) Hai-Lei Cui et al.   ORGANIC LETTERS

On the Mechanism of a Polyunsaturated Fatty Acid Double Bond Isomerase fromPropionibacterium acnes

(2009) Alena Liavonchanka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Role of Flavin as a General Acid-Base Catalyst with No Redox Function in Type 2 Isopentenyl-diphosphate Isomerase

(2009) Hideaki Unno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure and Putative Mechanism of 3-Methylitaconate-Δ-isomerase from Eubacterium barkeri

(2009) Milko Velarde et al.   JOURNAL OF MOLECULAR BIOLOGY

Computational Study of the Acid Dissociation of Esters and Lactones. A Case Study of Diketene

(2009) Rafael Gómez-Bombarelli et al.   JOURNAL OF ORGANIC CHEMISTRY

Nicotinamide-independent asymmetric bioreduction of CC-bonds via disproportionation of enones catalyzed by enoate reductases

(2009) Clemens Stueckler et al.   TETRAHEDRON

Asymmetric Bioreduction of CC Bonds using Enoate Reductases OPR1, OPR3 and YqjM: Enzyme-Based Stereocontrol

(2008) Mélanie Hall et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantiocomplementary Enzymes: Classification, Molecular Basis for Their Enantiopreference, and Prospects for Mirror-Image Biotransformations

(2008) Paul F. Mugford et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION