Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases

Biocatalytic access to nonracemic γ-oxo esters via stereoselective reduction using ene-reductases

(2017) Nikolaus G. Turrini et al.   GREEN CHEMISTRY

Exploitation of a Multienzymatic Stereoselective Cascade Process in the Synthesis of 2-Methyl-3-Substituted Tetrahydrofuran Precursors

(2017) Elisabetta Brenna et al.   JOURNAL OF ORGANIC CHEMISTRY

Alkene hydrogenation activity of enoate reductases for an environmentally benign biosynthesis of adipic acid

(2017) Jeong Chan Joo et al.   Chemical Science

Combining Rh-Catalyzed Diazocoupling and Enzymatic Reduction To Efficiently Synthesize Enantioenriched 2-Substituted Succinate Derivatives

(2017) Yajie Wang et al.   ACS Catalysis

Beyond Iron: Iridium-Containing P450 Enzymes for Selective Cyclopropanations of Structurally Diverse Alkenes

(2017) Hanna M. Key et al.   ACS Central Science

Bioreduction of α-Acetoxymethyl Enones: Proposal for an SN2′ Mechanism Catalyzed by Enereductase

(2016) Bruno R. S. Paula et al.   ADVANCED SYNTHESIS & CATALYSIS

Recombinant Cyanobacteria for the Asymmetric Reduction of C=C Bonds Fueled by the Biocatalytic Oxidation of Water

(2016) Katharina Köninger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short-Chain Dehydrogenases/Reductases

(2016) Antonios Lygidakis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Myoglobin-Catalyzed Olefination of Aldehydes

(2016) Vikas Tyagi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle-Kirmse Reaction

(2016) Vikas Tyagi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation

(2016) Joshua G. Gober et al.   CHEMBIOCHEM

Enantiocomplementary Synthesis of γ-Nitroketones Using Designed and Evolved Carboligases

(2016) Xavier Garrabou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An enantioselective artificial Suzukiase based on the biotin–streptavidin technology

(2016) Anamitra Chatterjee et al.   Chemical Science

Building Bridges: Biocatalytic C–C-Bond Formation toward Multifunctional Products

(2016) Nina G. Schmidt et al.   ACS Catalysis

Efficient In Situ Regeneration of NADH Mimics by an Artificial Metalloenzyme

(2016) Yasunori Okamoto et al.   ACS Catalysis

Finding the Selectivity Switch - A Rational Approach towards Stereocomplementary Variants of the Ene Reductase YqjM

(2015) Elisabeth Rüthlein et al.   ADVANCED SYNTHESIS & CATALYSIS

The Organic-Synthetic Potential of Recombinant Ene Reductases: Substrate-Scope Evaluation and Process Optimization

(2015) Tina Reß et al.   ChemCatChem

Ring-Closing and Cross-Metathesis with Artificial Metalloenzymes Created by Covalent Active Site-Directed Hybridization of a Lipase

(2015) Manuel Basauri-Molina et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reduction of α,β-Unsaturated Ketones by Old Yellow Enzymes: Mechanistic Insights from Quantum Mechanics/Molecular Mechanics Calculations

(2015) Richard Lonsdale et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Supramolecular Assembly of Artificial Metalloenzymes Based on the Dimeric Protein LmrR as Promiscuous Scaffold

(2015) Jeffrey Bos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation

(2015) Poonam Srivastava et al.   Nature Communications

Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran

(2014) Z. Jane Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Diastereoselective and Enantioselective Olefin Cyclopropanation Using Engineered Myoglobin-Based Catalysts

(2014) Melanie Bordeaux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conversion of Substrate Analogs Suggests a Michael Cyclization in Iridoid Biosynthesis

(2014) Stephanie Lindner et al.   CHEMISTRY & BIOLOGY

New developments in ‘ene’-reductase catalysed biological hydrogenations

(2014) Helen S Toogood et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations

(2014) Georg Steinkellner et al.   Nature Communications

Biocatalytic Methods for CC Bond Formation

(2013) Kateryna Fesko et al.   ChemCatChem

Designer cells for stereocomplementary de novo enzymatic cascade reactions based on laboratory evolution

(2013) Rubén Agudo et al.   CHEMICAL COMMUNICATIONS

A Hybrid Ring-Opening Metathesis Polymerization Catalyst Based on an Engineered Variant of the β-Barrel Protein FhuA

(2013) Freddi Philippart et al.   CHEMISTRY-A EUROPEAN JOURNAL

Squalene hopene cyclases: highly promiscuous and evolvable catalysts for stereoselective CC and CX bond formation

(2013) Stephan C Hammer et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

(2013) Pedro S Coelho et al.   Nature Chemical Biology

Asymmetric bioreduction of activated alkenes to industrially relevant optically active compounds

(2012) Christoph K. Winkler et al.   JOURNAL OF BIOTECHNOLOGY

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

(2012) P. S. Coelho et al.   SCIENCE

An artificial metalloenzyme for olefin metathesis

(2011) Clemens Mayer et al.   CHEMICAL COMMUNICATIONS

C−C Bond-Forming Lyases in Organic Synthesis

(2011) Margarita Brovetto et al.   CHEMICAL REVIEWS

An Artificial Metalloenzyme: Creation of a Designed Copper Binding Site in a Thermostable Protein

(2010) John Podtetenieff et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocatalytic Reductions and Chemical Versatility of the Old Yellow Enzyme Family of Flavoprotein Oxidoreductases

(2010) Helen S. Toogood et al.   ChemCatChem

Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold

(2009) David Coquière et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metamorphic enzyme assembly in polyketide diversification

(2009) Liangcai Gu et al.   NATURE

Asymmetric Bioreduction of CC Bonds using Enoate Reductases OPR1, OPR3 and YqjM: Enzyme-Based Stereocontrol

(2008) Mélanie Hall et al.   ADVANCED SYNTHESIS & CATALYSIS

Structure-Based Insight into the Asymmetric Bioreduction of the CC Double Bond of α,β-Unsaturated Nitroalkenes by Pentaerythritol Tetranitrate Reductase

(2008) Helen S. Toogood et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Bioreduction of Activated C=C Bonds UsingZymomonas mobilis NCR Enoate Reductase and Old Yellow Enzymes OYE 1–3 from Yeasts

(2008) Mélanie Hall et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Control of the Coordination Structure of Organometallic Palladium Complexes in an apo-Ferritin Cage

(2008) Satoshi Abe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY