Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance
出版年份 2022 全文链接
标题
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance
作者
关键词
-
出版物
Nature Communications
Volume 13, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-06-22
DOI
10.1038/s41467-022-31210-w
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
- (2022) Wanwisa Dejnirattisai et al. CELL
- Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization
- (2022) Sandile Cele et al. NATURE
- Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
- (2022) Yunlong Cao et al. NATURE
- Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses
- (2022) Benjamin L. Sievers et al. Science Translational Medicine
- Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188
- (2021) Gordon J. Lockbaum et al. Viruses-Basel
- Early Returns on Small Molecule Therapeutics for SARS-CoV-2
- (2021) Mark N. Namchuk ACS Infectious Diseases
- Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations
- (2021) Chun-Hui Zhang et al. ACS Central Science
- A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development
- (2021) Yingzhu Li et al. ACS Central Science
- Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode
- (2021) Gordon J. Lockbaum et al. BIOCHEMISTRY
- Discovery of Quinoxaline-Based P1–P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants
- (2021) Desaboini Nageswara Rao et al. JOURNAL OF MEDICINAL CHEMISTRY
- Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
- (2021) Bjoern Meyer et al. Nature Communications
- Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease
- (2021) Elizabeth A. MacDonald et al. ACS Infectious Diseases
- Clinical evidence that the pandemic from 1889 to 1891 commonly called the Russian flu might have been an earlier coronavirus pandemic
- (2021) Harald Brüssow et al. Microbial Biotechnology
- A tale of two antiviral targets — and the COVID-19 drugs that bind them
- (2021) Megan Cully NATURE REVIEWS DRUG DISCOVERY
- An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
- (2021) Dafydd R. Owen et al. SCIENCE
- Structural basis for strand-transfer inhibitor binding to HIV intasomes
- (2020) Dario Oliveira Passos et al. SCIENCE
- Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
- (2020) Zhenming Jin et al. NATURE
- Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
- (2020) Wenhao Dai et al. SCIENCE
- Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
- (2020) Linlin Zhang et al. SCIENCE
- Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors
- (2020) Ashley N. Matthew et al. mBio
- Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography
- (2020) Daniel W. Kneller et al. Nature Communications
- Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19
- (2020) Robert L. Hoffman et al. JOURNAL OF MEDICINAL CHEMISTRY
- Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
- (2020) Lindsey R. Baden et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
- (2020) Fernando P. Polack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors
- (2019) Ayşegül Özen et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase‐dihydropteroate synthase reveals the basis of sulfa resistance
- (2019) Penchit Chitnumsub et al. FEBS Journal
- Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors
- (2017) Xue Zhi Zhao et al. JOURNAL OF MEDICINAL CHEMISTRY
- Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS
- (2016) Arun K. Ghosh et al. JOURNAL OF MEDICINAL CHEMISTRY
- Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease
- (2016) Djadé I. Soumana et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Improving Viral Protease Inhibitors to Counter Drug Resistance
- (2016) Nese Kurt Yilmaz et al. TRENDS IN MICROBIOLOGY
- Evaluating the Role of Macrocycles in the Susceptibility of Hepatitis C Virus NS3/4A Protease Inhibitors to Drug Resistance
- (2013) Akbar Ali et al. ACS Chemical Biology
- Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
- (2013) G. Madhavi Sastry et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
- (2012) Ali M. Zaki et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors
- (2012) Keith P. Romano et al. PLoS Pathogens
- Systematic review of influenza resistance to the neuraminidase inhibitors
- (2011) Kristian Thorlund et al. BMC INFECTIOUS DISEASES
- Hepatitis C virus resistance to protease inhibitors
- (2011) Philippe Halfon et al. JOURNAL OF HEPATOLOGY
- Molecular Mechanisms of Viral and Host Cell Substrate Recognition by Hepatitis C Virus NS3/4A Protease
- (2011) K. P. Romano et al. JOURNAL OF VIROLOGY
- Preexisting drug-resistance mutations reveal unique barriers to resistance for distinct antivirals
- (2011) M. Robinson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance
- (2010) M. N. L. Nalam et al. JOURNAL OF VIROLOGY
- Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding
- (2010) K. P. Romano et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular Basis for Drug Resistance in HIV-1 Protease
- (2010) Akbar Ali et al. Viruses-Basel
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