Dexmedetomidine Inhibits Gasdermin D-Induced Pyroptosis via the PI3K/AKT/GSK3β Pathway to Attenuate Neuroinflammation in Early Brain Injury After Subarachnoid Hemorrhage in Rats
出版年份 2022 全文链接
标题
Dexmedetomidine Inhibits Gasdermin D-Induced Pyroptosis via the PI3K/AKT/GSK3β Pathway to Attenuate Neuroinflammation in Early Brain Injury After Subarachnoid Hemorrhage in Rats
作者
关键词
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出版物
Frontiers in Cellular Neuroscience
Volume 16, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2022-06-21
DOI
10.3389/fncel.2022.899484
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Dexmedetomidine alleviates hepatic ischaemia‐reperfusion injury via the PI3K/AKT/Nrf2‐NLRP3 pathway
- (2021) Yan Wu et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage
- (2020) Bin Yuan et al. Cell Death & Disease
- Dexmedetomidine Improves Cardiovascular and Ventilatory Outcomes in Critically Ill Patients: Basic and Clinical Approaches
- (2020) Rodrigo L. Castillo et al. Frontiers in Pharmacology
- The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity
- (2020) Eduardo A. González et al. ARCHIVES OF TOXICOLOGY
- Pyrroloquinoline Quinine and LY294002 Changed Cell Cycle and Apoptosis by Regulating PI3K-AKT-GSK3β Pathway in SH-SY5Y Cells
- (2020) Hongyun Ji et al. NEUROTOXICITY RESEARCH
- A Review of Hematoma Components Clearance Mechanism After Subarachnoid Hemorrhage
- (2020) Pengjie Pan et al. Frontiers in Neuroscience
- TREM-1 Exacerbates Neuroinflammatory Injury via NLRP3 Inflammasome-Mediated Pyroptosis in Experimental Subarachnoid Hemorrhage
- (2020) Pengfei Xu et al. Translational Stroke Research
- Melatonin Enhances the Therapeutic Effect of Plasma Exosomes Against Cerebral Ischemia-Induced Pyroptosis Through the TLR4/NF-κB Pathway
- (2020) Kankai Wang et al. Frontiers in Neuroscience
- Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch
- (2019) Wenchao Liu et al. Journal of Neuroinflammation
- Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro
- (2019) Dongping Zhang et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis
- (2019) Yi-Bing Sun et al. Cell Death & Disease
- Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis
- (2019) Xi-e Xu et al. BRAIN BEHAVIOR AND IMMUNITY
- Inflammasomes in neuroinflammatory and neurodegenerative diseases
- (2019) Sofie Voet et al. EMBO Molecular Medicine
- Silencing of SNHG12 Enhanced the Effectiveness of MSCs in Alleviating Ischemia/Reperfusion Injuries via the PI3K/AKT/mTOR Signaling Pathway
- (2019) Yuanzhi Li et al. Frontiers in Neuroscience
- Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in rats
- (2018) Zongyi Xie et al. BRAIN BEHAVIOR AND IMMUNITY
- Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: The TLR4/NF-κB pathway and the NLRP3 inflammasome may be involved in the mechanism
- (2018) Dongpei Yin et al. BRAIN RESEARCH
- Bradykinin B2 receptors play a neuroprotective role in Hypoxia/reoxygenation injury related to pyroptosis pathway
- (2018) Min Tang et al. CURRENT NEUROVASCULAR RESEARCH
- Association between dexmedetomidine use and neurological outcomes in aneurysmal subarachnoid hemorrhage patients: A retrospective observational study
- (2018) Tomoya Okazaki et al. JOURNAL OF CRITICAL CARE
- Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage
- (2018) Yue Lu et al. Journal of Neuroinflammation
- Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo
- (2018) Wei Liu et al. Journal of Neuroinflammation
- A Brief History of Microglial Ultrastructure: Distinctive Features, Phenotypes, and Functions Discovered Over the Past 60 Years by Electron Microscopy
- (2018) Julie C. Savage et al. Frontiers in Immunology
- Dexmedetomidine restores autophagy and cardiac dysfunction in rats with streptozotocin-induced diabetes mellitus
- (2018) Ju Eun Oh et al. ACTA DIABETOLOGICA
- DHA attenuates hepatic ischemia reperfusion injury by inhibiting pyroptosis and activating PI3K/Akt pathway
- (2018) Ziyi Li et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- TSG-6 attenuates inflammation-induced brain injury via modulation of microglial polarization in SAH rats through the SOCS3/STAT3 pathway
- (2018) Ran Li et al. Journal of Neuroinflammation
- High wall shear stress beyond a certain range in the parent artery could predict the risk of anterior communicating artery aneurysm rupture at follow-up
- (2018) Xin Zhang et al. JOURNAL OF NEUROSURGERY
- Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer
- (2018) Josephraj Sophia et al. Cell Death & Disease
- Effects of Dexmedetomidine Postconditioning on Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Role of the PI3K/Akt-Dependent Signaling Pathway
- (2018) Xiangyang Cheng et al. Journal of Diabetes Research
- Dexmedetomidine attenuates propofol-induce neuroapoptosis partly via the activation of the PI3k/Akt/GSK3β pathway in the hippocampus of neonatal rats
- (2017) Jing Lv et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway
- (2017) Jun Zeng et al. Journal of Neuroinflammation
- Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
- (2017) Jianjin Shi et al. TRENDS IN BIOCHEMICAL SCIENCES
- GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
- (2016) Lorenzo Sborgi et al. EMBO JOURNAL
- Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review
- (2016) Brandon Lucke-Wold et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Pramipexole-Induced Hypothermia Reduces Early Brain Injury via PI3K/AKT/GSK3β pathway in Subarachnoid Hemorrhage rats
- (2016) Junwei Ma et al. Scientific Reports
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
- (2015) Wan-ting He et al. CELL RESEARCH
- Human Albumin Improves Long-Term Behavioral Sequelae After Subarachnoid Hemorrhage Through Neurovascular Remodeling
- (2015) Yi Xie et al. CRITICAL CARE MEDICINE
- Dexmedetomidine Attenuates Bilirubin-Induced Lung Alveolar Epithelial Cell Death In Vitro and In Vivo*
- (2015) Jian Cui et al. CRITICAL CARE MEDICINE
- Aneurysmal subarachnoid hemorrhage: pathobiology, current treatment and future directions
- (2015) Joseph C Serrone et al. Expert Review of Neurotherapeutics
- Pyroptotic cell death defends against intracellular pathogens
- (2015) Ine Jorgensen et al. IMMUNOLOGICAL REVIEWS
- The inhibitory effect of mesenchymal stem cell on blood–brain barrier disruption following intracerebral hemorrhage in rats: contribution of TSG-6
- (2015) Min Chen et al. Journal of Neuroinflammation
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- Aneurysmal subarachnoid hemorrhage: pathobiology, current treatment and future directions
- (2015) Joseph C Serrone et al. Expert Review of Neurotherapeutics
- Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats
- (2014) Lin Chen et al. NEUROCHEMISTRY INTERNATIONAL
- Delayed neurological deterioration after subarachnoid haemorrhage
- (2013) R. Loch Macdonald Nature Reviews Neurology
- Controversies and evolving new mechanisms in subarachnoid hemorrhage
- (2013) Sheng Chen et al. PROGRESS IN NEUROBIOLOGY
- Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death
- (2010) Gonzalo Arboleda et al. NEUROTOXICOLOGY
- A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model
- (2007) Takashi Sugawara et al. JOURNAL OF NEUROSCIENCE METHODS
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