A Brief History of Microglial Ultrastructure: Distinctive Features, Phenotypes, and Functions Discovered Over the Past 60 Years by Electron Microscopy

Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia

(2018) Juan G. Zarruk et al.   EXPERIMENTAL NEUROLOGY

Prenatal Immune Challenge in Mice Leads to Partly Sex-Dependent Behavioral, Microglial, and Molecular Abnormalities Associated with Schizophrenia

(2018) Chin W. Hui et al.   Frontiers in Molecular Neuroscience

In situ RT-PCR Optimized for Electron Microscopy Allows Description of Subcellular Morphology of Target mRNA-Expressing Cells in the Brain

(2017) Laura Cubas-Nuñez et al.   Frontiers in Cellular Neuroscience

Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress

(2016) Giampaolo Milior et al.   BRAIN BEHAVIOR AND IMMUNITY

Satellite microglia show spontaneous electrical activity that is uncorrelated with activity of the attached neuron

(2016) Emile Wogram et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Inhomogeneous distribution of Iba-1 characterizes microglial pathology in Alzheimer's disease

(2016) Jasmin Tischer et al.   GLIA

Dark microglia: A new phenotype predominantly associated with pathological states

(2016) Kanchan Bisht et al.   GLIA

3D electron tomography of brain tissue unveils distinct Golgi structures that sequester cytoplasmic contents in neurons

(2016) Maria Rosario Fernandez-Fernandez et al.   JOURNAL OF CELL SCIENCE

Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells

(2016) Marie-Eve Tremblay et al.   Journal of Neuroinflammation

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

(2016) Tuan Leng Tay et al.   JOURNAL OF PHYSIOLOGY-LONDON

An introduction to sample preparation and imaging by cryo-electron microscopy for structural biology

(2016) Rebecca F. Thompson et al.   METHODS

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

(2016) G. O. Sipe et al.   Nature Communications

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Distinction of Neurons, Glia and Endothelial Cells in the Cerebral Cortex: An Algorithm Based on Cytological Features

(2016) Miguel Á. García-Cabezas et al.   Frontiers in Neuroanatomy

Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques

(2016) Kanchan Bisht et al.   Jove-Journal of Visualized Experiments

Effects of LDL Receptor Modulation on Lymphatic Function

(2016) Andreea Milasan et al.   Scientific Reports

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Priming the Inflammatory Pump of the CNS after Traumatic Brain Injury

(2015) Kristina G. Witcher et al.   TRENDS IN NEUROSCIENCES

From the Cajal alumni Achúcarro and Río-Hortega to the rediscovery of never-resting microglia

(2015) Marie-Ève Tremblay et al.   Frontiers in Neuroanatomy

Extracellular space preservation aids the connectomic analysis of neural circuits

(2015) Marta Pallotto et al.   eLife

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

(2015) Natalya Korogod et al.   eLife

Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation

(2014) T. J. van Ham et al.   Disease Models & Mechanisms

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Exploring the third dimension: Volume electron microscopy comes of age

(2014) Christopher J. Peddie et al.   MICRON

Semiautomated correlative 3D electron microscopy of in vivo–imaged axons and dendrites

(2014) Bohumil Maco et al.   Nature Protocols

Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain

(2014) Zhihong Chen et al.   Nature Communications

Microglia Modulate Wiring of the Embryonic Forebrain

(2014) Paola Squarzoni et al.   Cell Reports

Microglial pathology

(2014) Wolfgang J Streit et al.   Acta Neuropathologica Communications

Two-Photon Excitation STED Microscopy in Two Colors in Acute Brain Slices

(2013) Philipp Bethge et al.   BIOPHYSICAL JOURNAL

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Neurotransmitter signaling in the pathophysiology of microglia

(2013) María Domercq et al.   Frontiers in Cellular Neuroscience

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Ptychographic electron microscopy using high-angle dark-field scattering for sub-nanometre resolution imaging

(2012) M.J. Humphry et al.   Nature Communications

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

(2010) Sungho Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Mapping of fluorescent protein-expressing neurons and axon pathways in adult and developing Thy1-eYFP-H transgenic mice

(2010) Cesar Porrero et al.   BRAIN RESEARCH

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Preparation of Mouse Brain Tissue for Immunoelectron Microscopy

(2010) Marie-Éve Tremblay et al.   Jove-Journal of Visualized Experiments

Degenerating Synaptic Boutons in Prion Disease

(2009) Zuzana Šišková et al.   AMERICAN JOURNAL OF PATHOLOGY

Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases

(2009) Y. Xu et al.   BLOOD

Morphological and ultrastructural features of Iba1-immunolabeled microglial cells in the hippocampal dentate gyrus

(2009) Lee A. Shapiro et al.   BRAIN RESEARCH

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Serial Section Scanning Electron Microscopy of Adult Brain Tissue Using Focused Ion Beam Milling

(2008) G. Knott et al.   JOURNAL OF NEUROSCIENCE

Correlative light-electron microscopy (CLEM) combining live-cell imaging and immunolabeling of ultrathin cryosections

(2008) Carolien van Rijnsoever et al.   NATURE METHODS