Novel Therapeutic Strategies for Ischemic Stroke: Recent Insights into Autophagy

miR-155-5p in Extracellular Vesicles Derived from Choroid Plexus Epithelial Cells Promotes Autophagy and Inflammation to Aggravate Ischemic Brain Injury in Mice

(2022) Zhang Yang et al.   Oxidative Medicine and Cellular Longevity

Role of Mitophagy in the Pathogenesis of Stroke: From Mechanism to Therapy

(2022) Wei-Jie Zhong et al.   Oxidative Medicine and Cellular Longevity

PTP1B inhibitor alleviates deleterious microglial activation and neuronal injury after ischemic stroke by modulating the ER stress-autophagy axis via PERK signaling in microglia

(2021) Yu Zhu et al.   Aging-US

Autophagy Paradox of Cancer: Role, Regulation, and Duality

(2021) Amit Kumar Verma et al.   Oxidative Medicine and Cellular Longevity

Beyond Self-Recycling: Cell-Specific Role of Autophagy in Atherosclerosis

(2021) James M. Henderson et al.   Cells

Arctium lappa L. roots ameliorates cerebral ischemia through inhibiting neuronal apoptosis and suppressing AMPK/mTOR-mediated autophagy

(2021) Yue Yang et al.   PHYTOMEDICINE

Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation

(2021) Bin Han et al.   Genome Medicine

Propofol Protects against Cerebral Ischemia/Reperfusion Injury by Down-Regulating Long Noncoding RNA SNHG14

(2021) Bei Sun et al.   ACS Chemical Neuroscience

Betulinic Acid Ameliorates Cerebral Injury in Middle Cerebral Artery Occlusion Rats through Regulating Autophagy

(2021) Yuelin Zhao et al.   ACS Chemical Neuroscience

Autophagy in Alzheimer’s Disease Pathogenesis: Therapeutic Potential and Future Perspectives

(2021) Zhigang Zhang et al.   AGEING RESEARCH REVIEWS

LncRNA AC136007.2 alleviates cerebral ischemic-reperfusion injury by suppressing autophagy

(2021) Na Liu et al.   Aging-US

LncRNA-MIAT promotes neural cell autophagy and apoptosis in ischemic stroke by up-regulating REDD1

(2021) Xiaqing Guo et al.   BRAIN RESEARCH

Dexmedetomidine attenuates neuronal injury induced by cerebral ischemia‑reperfusion by regulating miR‑199a

(2021) Yulin Zhu et al.   Molecular Medicine Reports

Circular RNA 0025984 Ameliorates Ischemic Stroke Injury and Protects Astrocytes Through miR-143-3p/TET1/ORP150 Pathway

(2021) Daixuan Zhou et al.   MOLECULAR NEUROBIOLOGY

Natural Products in Therapeutic Management of Multineurodegenerative Disorders by Targeting Autophagy

(2021) Sibhghatulla Shaikh et al.   Oxidative Medicine and Cellular Longevity

Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke

(2021) Anthony N. Patrizz et al.   Cells

Autophagy and Mitochondrial Homeostasis During Infection: A Double-Edged Sword

(2021) Sutian Wang et al.   Frontiers in Cell and Developmental Biology

The Multifaceted Role of Flavonoids in Cancer Therapy: Leveraging Autophagy with a Double-Edged Sword

(2021) Zhe Zhang et al.   Antioxidants

Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion

(2021) Zhenguo Yang et al.   MOLECULAR THERAPY

p53 Inhibition Protects against Neuronal Ischemia/Reperfusion Injury by the p53/PRAS40/mTOR Pathway

(2021) Jianlan Zhao et al.   Oxidative Medicine and Cellular Longevity

Electroacupuncture Pretreatment Prevents Ischemic Stroke and Inhibits Wnt Signaling-Mediated Autophagy Through the Regulation of GSK-3β Phosphorylation

(2020) Chengyu Chen et al.   BRAIN RESEARCH BULLETIN

Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells

(2020) Jie Zhang et al.   Cellular & Molecular Immunology

Repetitive Transcranial Magnetic Stimulation Alleviates Neurological Deficits After Cerebral Ischemia Through Interaction Between RACK1 and BDNF exon IV by the Phosphorylation-Dependent Factor MeCP2

(2020) Hongzhan Li et al.   Neurotherapeutics

Recombinant Adiponectin Peptide Ameliorates Brain Injury Following Intracerebral Hemorrhage by Suppressing Astrocyte-Derived Inflammation via the Inhibition of Drp1-Mediated Mitochondrial Fission

(2020) Xun Wu et al.   Translational Stroke Research

Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury

(2020) Claudia Espinosa-Garcia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blockade of Nogo-A/Nogo-66 receptor 1 (NgR1) Inhibits Autophagic Activation and Prevents Secondary Neuronal Damage in the Thalamus after Focal Cerebral Infarction in Hypertensive Rats

(2020) Wei Xu et al.   NEUROSCIENCE

Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen–glucose deprivation/reoxygenation

(2020) Chen Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of Long Noncoding RNA MEG3/MiR-378/GRB2 Axis in Neuronal Autophagy and Neurological Functional Impairment in Ischemic Stroke

(2020) Hong-Cheng Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium Tanshinone IIA Sulfonate Protects Against Cerebral Ischemia–reperfusion Injury by Inhibiting Autophagy and Inflammation

(2020) Lei Wang et al.   NEUROSCIENCE

Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia

(2020) Zelin Lai et al.   Cell and Bioscience

Selective autophagy as a therapeutic target for neurological diseases

(2020) Weilin Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rapamycin Pretreatment Alleviates Cerebral Ischemia/Reperfusion Injury in Dose-Response Manner Through Inhibition of the Autophagy and NFκB Pathways in Rats

(2020) Liru Li et al.   Dose-Response

Shrm4 contributes to autophagy inhibition and neuroprotection following ischemic stroke by mediating GABA B receptor activation

(2020) Ya‐Jing Yuan et al.   FASEB JOURNAL

C1q/tumor necrosis factor-related protein-1 attenuates microglia autophagy and inflammatory response by regulating the Akt/mTOR pathway

(2020) Huilin Wang et al.   LIFE SCIENCES

A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy

(2020) Jia-Li Chen et al.   NEUROPHARMACOLOGY

Inhibition of miR-497 improves functional outcome after ischemic stroke by enhancing neuronal autophagy in young and aged rats

(2019) Xudong Chen et al.   NEUROCHEMISTRY INTERNATIONAL

Autophagy in liver diseases: Time for translation?

(2019) Manon Allaire et al.   JOURNAL OF HEPATOLOGY

Interleukin-17A-mediated alleviation of cortical astrocyte ischemic injuries affected the neurological outcome of mice with ischemic stroke

(2019) Qingqing Dai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)

(2019) Philip Wing-Lok Ho et al.   Autophagy

Autophagy dysfunction in Alzheimer’s disease: mechanistic insights and new therapeutic opportunities

(2019) Antonio Di Meco et al.   BIOLOGICAL PSYCHIATRY

Glia-specific autophagy dysfunction in ALS

(2019) Laura Strohm et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pharmacological Autophagy Regulators as Therapeutic Agents for Inflammatory Bowel Diseases

(2019) Sruthi Vijaya Retnakumar et al.   TRENDS IN MOLECULAR MEDICINE

Development and Cell Biology of the Blood-Brain Barrier

(2019) Urs H. Langen et al.   Annual Review of Cell and Developmental Biology

TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury

(2019) Ding-Mei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy is essential for oligodendrocyte differentiation, survival, and proper myelination

(2019) Andrew N. Bankston et al.   GLIA

Suppression of REDD1 attenuates oxygen glucose deprivation/reoxygenation‐evoked ischemic injury in neuron by suppressing mTOR‐mediated excessive autophagy

(2019) Juguang Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Activation of Sigma-1 Receptor Enhanced Pericyte Survival via the Interplay Between Apoptosis and Autophagy: Implications for Blood–Brain Barrier Integrity in Stroke

(2019) Yuan Zhang et al.   Translational Stroke Research

Baicalein administered in the subacute phase ameliorates ischemia-reperfusion-induced brain injury by reducing neuroinflammation and neuronal damage

(2019) Shilun Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Activation of G protein‐coupled receptor 30 protects neurons by regulating autophagy in astrocytes

(2019) Xin‐Shang Wang et al.   GLIA

Role of JNK Signaling Pathway in Dexmedetomidine Post-Conditioning-Induced Reduction of the Inflammatory Response and Autophagy Effect of Focal Cerebral Ischemia Reperfusion Injury in Rats

(2019) Yulin Zhu et al.   INFLAMMATION

Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke

(2019) Yuzhu Wang et al.   Neuroscience Bulletin

Autophagy in Kidney Disease

(2019) Mary E. Choi   Annual Review of Physiology

Therapeutic effects of JLX-001 on ischemic stroke by inducing autophagy via AMPK-ULK1 signaling pathway in rats

(2019) Lu-yao Ao et al.   BRAIN RESEARCH BULLETIN

Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischemia/reperfusion injury by inhibiting GSK‐3 β ‐mediated activation of autophagy

(2019) Jianmei Gao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Schizandrin Protects against OGD/R-Induced Neuronal Injury by Suppressing Autophagy: Involvement of the AMPK/mTOR Pathway

(2019) Guangyun Wang et al.   MOLECULES

Dexmedetomidine Protects Against Oxygen–Glucose Deprivation-Induced Injury Through Inducing Astrocytes Autophagy via TSC2/mTOR Pathway

(2019) Chen Zhu et al.   NEUROMOLECULAR MEDICINE

A small molecule protects mitochondrial integrity by inhibiting mTOR activity

(2019) Ran Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pterostilbene Attenuates Astrocytic Inflammation and Neuronal Oxidative Injury After Ischemia-Reperfusion by Inhibiting NF-κB Phosphorylation

(2019) Haixiao Liu et al.   Frontiers in Immunology

Chaperone-Mediated Autophagy in the Liver: Good or Bad?

(2019) Srikanta Dash et al.   Cells

Microphysiological systems for recapitulating physiology and function of blood-brain barrier

(2019) Suyeong Seo et al.   BIOMATERIALS

Roles of autophagy in breast cancer treatment: Target, bystander or benefactor

(2019) Liliya Tyutyunyk-Massey et al.   SEMINARS IN CANCER BIOLOGY

Noncanonical autophagy in dendritic cells triggers CNS autoimmunity

(2018) Christian W. Keller et al.   Autophagy

Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke

(2018) Bing Han et al.   Autophagy

Ginkgolide K promotes astrocyte proliferation and migration after oxygen-glucose deprivation via inducing protective autophagy through the AMPK/mTOR/ULK1 signaling pathway

(2018) Ying Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ezetimibe, a NPC1L1 inhibitor, attenuates neuronal apoptosis through AMPK dependent autophagy activation after MCAO in rats

(2018) Jing Yu et al.   EXPERIMENTAL NEUROLOGY

A molecular perspective of mammalian autophagosome biogenesis

(2018) Thomas J. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

(2018) Somayyeh Hamzei Taj et al.   Journal of Neuroinflammation

Blocking Autophagy in Oligodendrocytes Limits Functional Recovery after Spinal Cord Injury

(2018) Sujata Saraswat Ohri et al.   JOURNAL OF NEUROSCIENCE

The Synergistic Neuroprotective Effects of Combined Rosuvastatin and Resveratrol Pretreatment against Cerebral Ischemia/Reperfusion Injury

(2018) Ying Liu et al.   Journal of Stroke & Cerebrovascular Diseases

RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway

(2018) Yong Ni et al.   NEUROSCIENCE

Autophagy- and MMP-2/9-mediated Reduction and Redistribution of ZO-1 Contribute to Hyperglycemia-increased Blood–Brain Barrier Permeability During Early Reperfusion in Stroke

(2018) Shuai Zhang et al.   NEUROSCIENCE

The Synergistic Neuroprotective Effects of Combined Rosuvastatin and Resveratrol Pretreatment against Cerebral Ischemia/Reperfusion Injury

(2018) Ying Liu et al.   Journal of Stroke & Cerebrovascular Diseases

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

(2018) Seiji Kaji et al.   Stem Cell Reports

Autophagy in Cardiovascular Aging

(2018) Mahmoud Abdellatif et al.   CIRCULATION RESEARCH

The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies

(2018) Daniel J Beard et al.   International Journal of Stroke

Rapamycin in ischemic stroke: Old drug, new tricks?

(2018) Gina Hadley et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Propofol inhibited autophagy through Ca2+/CaMKKβ/AMPK/mTOR pathway in OGD/R-induced neuron injury

(2018) Bei Sun et al.   MOLECULAR MEDICINE

Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases

(2018) Jun Ren et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction

(2017) Qi He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Autophagosome Maturation and Fusion

(2017) Fulvio Reggiori et al.   JOURNAL OF MOLECULAR BIOLOGY

Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings

(2017) Dayun Feng et al.   JOURNAL OF PINEAL RESEARCH

Long noncoding RNA Malat1 is a potent autophagy inducer protecting brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-26b and upregulating ULK2 expression

(2017) Zhijun Li et al.   NEUROSCIENCE

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

Astrocyte Autophagy Flux Protects Neurons Against Oxygen-Glucose Deprivation and Ischemic/Reperfusion Injury

(2017) Xue Liu et al.   REJUVENATION RESEARCH

Dexmedetomidine Protects Mouse Brain from Ischemia-Reperfusion Injury via Inhibiting Neuronal Autophagy through Up-Regulating HIF-1α

(2017) Cong Luo et al.   Frontiers in Cellular Neuroscience

Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain

(2017) Dan-Dan Song et al.   Cell Death & Disease

Inhibition of autophagy blocks cathepsins–tBid–mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes

(2017) Xian-Yong Zhou et al.   Cell Death & Disease

Regulation of Microglia and Macrophage Polarization via Apoptosis Signal-Regulating Kinase 1 Silencing after Ischemic/Hypoxic Injury

(2017) So Yeong Cheon et al.   Frontiers in Molecular Neuroscience

Netrin-1 Ameliorates Blood-Brain Barrier Impairment Secondary to Ischemic Stroke via the Activation of PI3K Pathway

(2017) Jian Yu et al.   Frontiers in Neuroscience

Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats

(2017) Meiling Wu et al.   Annals of Clinical and Translational Neurology

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

(2016) Cuicui Xie et al.   Autophagy

Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion

(2016) Cong-Yuan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Potential role of microRNA-7 in the anti-neuroinflammation effects of nicorandil in astrocytes induced by oxygen-glucose deprivation

(2016) Yin-Feng Dong et al.   Journal of Neuroinflammation

Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines

(2016) Mousumi Ghosh et al.   Journal of Neuroinflammation

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island

(2016) Sebastian I. Arriola Apelo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Effects of rapamycin pretreatment on blood-brain barrier disruption in cerebral ischemia-reperfusion

(2016) Oak Z. Chi et al.   NEUROSCIENCE LETTERS

Astrocytes: Integrative Regulators of Neuroinflammation in Stroke and Other Neurological Diseases

(2016) Egle Cekanaviciute et al.   Neurotherapeutics

Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity

(2016) Minshu Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

(2016) Zhongwu Liu et al.   PROGRESS IN NEUROBIOLOGY

Microautophagy in nutritive phagocytes of sea urchins

(2016) Alexander V. Kalachev et al.   PROTOPLASMA

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Resveratrol improves delayed r-tPA treatment outcome by reducing MMPs

(2015) J. Chen et al.   ACTA NEUROLOGICA SCANDINAVICA

Neurovascular Regulation in the Ischemic Brain

(2015) Katherine Jackman et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypoxia induces microglia autophagy and neural inflammation injury in focal cerebral ischemia model

(2015) Zhao Yang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Inhibition of mTOR Pathway by Rapamycin Reduces Brain Damage in Rats Subjected to Transient Forebrain Ischemia

(2015) Xiao Yang et al.   International Journal of Biological Sciences

Autophagy protects human brain microvascular endothelial cells against methylglyoxal-induced injuries, reproducible in a cerebral ischemic model in diabetic rats

(2015) Lili Fang et al.   JOURNAL OF NEUROCHEMISTRY

The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage

(2015) J. Ni et al.   JOURNAL OF NEUROSCIENCE

Nitric Oxide Interacts with Caveolin-1 to Facilitate Autophagy-Lysosome-Mediated Claudin-5 Degradation in Oxygen-Glucose Deprivation-Treated Endothelial Cells

(2015) Jie Liu et al.   MOLECULAR NEUROBIOLOGY

Autophagy and autophagy-related proteins in the immune system

(2015) Shusaku T Shibutani et al.   NATURE IMMUNOLOGY

Bcl-2 Phosphorylation Triggers Autophagy Switch and Reduces Mitochondrial Damage in Limb Remote Ischemic Conditioned Rats After Ischemic Stroke

(2015) Zhifeng Qi et al.   Translational Stroke Research

To be or not to be, the level of autophagy is the question: Dual roles of autophagy in the survival response to starvation

(2014) Chanhee Kang et al.   Autophagy

RETRACTED: Rapamycin induces of protective autophagy in vascular endothelial cells exposed to oxygen–glucose deprivation

(2014) Tomasz Urbanek et al.   BRAIN RESEARCH

Beneficial effects of gfap/vimentin reactive astrocytes for axonal remodeling and motor behavioral recovery in mice after stroke

(2014) Zhongwu Liu et al.   GLIA

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

Neuronal autophagy in cerebral ischemia – a potential target for neuroprotective strategies?

(2014) Bożena Gabryel et al.   Pharmacological Reports

Evaluation of the Protective Potential of Brain Microvascular Endothelial Cell Autophagy on Blood–Brain Barrier Integrity During Experimental Cerebral Ischemia–Reperfusion Injury

(2014) Haiying Li et al.   Translational Stroke Research

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

The Involvement of Autophagy Pathway in Exaggerated Ischemic Brain Damage in Diabetic Mice

(2013) Ning Wei et al.   CNS Neuroscience & Therapeutics

Worldwide Reported Use of IV Tissue Plasminogen Activator for Acute Ischemic Stroke

(2013) Aaron L. Berkowitz et al.   International Journal of Stroke

The regulatory role of NF-κB in autophagy-like cell death after focal cerebral ischemia in mice

(2013) W.-L. Li et al.   NEUROSCIENCE

Modulation of macrophage phenotype by cell shape

(2013) F. Y. McWhorter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

(2012) Pei Wang et al.   Autophagy

AKT/GSK3β-Dependent Autophagy Contributes to the Neuroprotection of Limb Remote Ischemic Postconditioning in the Transient Cerebral Ischemic Rat Model

(2012) Zhi-Feng Qi et al.   CNS Neuroscience & Therapeutics

Excessive Autophagy Contributes to Neuron Death in Cerebral Ischemia

(2012) Ruoyang Shi et al.   CNS Neuroscience & Therapeutics

A Double-Edged Sword with Therapeutic Potential: An Updated Role of Autophagy in Ischemic Cerebral Injury

(2012) Kai Wei et al.   CNS Neuroscience & Therapeutics

miR-21 represses FasL in microglia and protects against microglia-mediated neuronal cell death following hypoxia/ischemia

(2012) Li Zhang et al.   GLIA

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage

(2012) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Autophagy Contributes to Ischemic Postconditioning-Induced Neuroprotection against Focal Cerebral Ischemia in Rats

(2012) Li Gao et al.   PLoS One

Protecting White Matter From Stroke Injury

(2012) Carlos Matute et al.   STROKE

Neuronal autophagy in cerebral ischemia

(2012) Feng Xu et al.   Neuroscience Bulletin

Autophagy activation is involved in neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats

(2011) Wenjun Yan et al.   BRAIN RESEARCH

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia

(2010) Ai-Ping Qin et al.   Autophagy

Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

(2010) Silvia Carloni et al.   Autophagy

Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic

(2010) Lu Li et al.   GLIA

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Postischemic treatment of neonatal cerebral ischemia should target autophagy

(2009) Julien Puyal et al.   ANNALS OF NEUROLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

(2009) Zheng Gang Zhang et al.   LANCET NEUROLOGY

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

(2009) Teresa L M Thurston et al.   NATURE IMMUNOLOGY

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

(2008) Masato Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

Quality of Life in Stroke Survivors after Local Intra-Arterial Thrombolysis

(2008) Urs Fischer et al.   CEREBROVASCULAR DISEASES

Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury

(2008) Silvia Carloni et al.   NEUROBIOLOGY OF DISEASE