Novel 1,3-Thiazole Analogues with Potent Activity against Breast Cancer: A Design, Synthesis, In Vitro, and In Silico Study

Discovery of 2‐Amino‐4H‐1, 3, 4‐thiadiazine‐5(6H)‐one Derivatives and Their In Vitro Antitumor Investigation

(2022) Faten Zahran Mohammed et al.   ChemistrySelect

Design, synthesis and docking studies of new hydrazinyl-thiazole derivatives as anticancer and antimicrobial agents

(2022) Abeer M. El-Naggar et al.   Journal of Saudi Chemical Society

Synthesis and Biological Evaluation of Novel Thiazole Analogs with Both Anti‐Proliferative and Mechanistic Analyses and Molecular Docking Studies

(2022) Abdoullah Bimoussa et al.   ChemistrySelect

New Advances in Targeted Therapy of HER2-Negative Breast Cancer

(2022) Junsha An et al.   Frontiers in Oncology

Acetylsalicylic Acid Suppresses Alcoholism-Induced Cognitive Impairment Associated with Atorvastatin Intake by Targeting Cerebral miRNA155 and NLRP3: In Vivo, and In Silico Study

(2022) Doaa I. Mohamed et al.   Pharmaceutics

Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study

(2022) Doaa I. Mohamed et al.   Pharmaceuticals

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

(2021) Anca-Maria Borcea et al.   MOLECULES

Breast cancer

(2021) Sibylle Loibl et al.   LANCET

New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study

(2021) Ahmed Gaber et al.   MOLECULES

Antiproliferative activity of thiazole and oxazole derivatives: A systematic review of in vitro and in vivo studies

(2021) Nancy Y. Guerrero-Pepinosa et al.   BIOMEDICINE & PHARMACOTHERAPY

Novel N-bridged pyrazole-1-carbothioamides with potential antiproliferative activity: design, synthesis, in vitro and in silico studies

(2021) Islam H El Azab et al.   Future Medicinal Chemistry

Stereoselective Synthesis of Novel Sphingoid Bases Utilized for Exploring the Secrets of Sphinx

(2021) Essa M. Saied et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thiazole Ring—A Biologically Active Scaffold

(2021) Anthi Petrou et al.   MOLECULES

Design, Synthesis and Anticancer Evaluation of Substituted Cinnamic Acid Bearing 2-Quinolone Hybrid Derivatives

(2021) Ali H. Abu Almaaty et al.   MOLECULES

U.S. FDA Drug Approvals for Breast Cancer — A Decade in Review

(2021) Shaily Arora et al.   CLINICAL CANCER RESEARCH

Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B-Raf

(2021) Jaclyn R. Patterson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytotoxic and antiproliferative activity of thiazole derivatives of Ochraceolide A

(2021) Angel D. Herrera-España et al.   NATURAL PRODUCT RESEARCH

Piperine for treating breast cancer: A review of molecular mechanisms, combination with anticancer drugs, and nanosystems

(2021) Christian Rafael Quijia et al.   PHYTOTHERAPY RESEARCH

A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19

(2021) Essa M. Saied et al.   Pharmaceutics

Vitamin D3 Prevents the Deleterious Effects of Testicular Torsion on Testis by Targeting miRNA-145 and ADAM17: In Silico and In Vivo Study

(2021) Doaa I. Mohamed et al.   Pharmaceuticals

Clinical Review on the Management of Hormone Receptor–Positive Metastatic Breast Cancer

(2021) Nicholas P. McAndrew et al.   JCO Oncology Practice

Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors

(2020) Kirsten McAulay et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications

(2020) Nagaraju Kerru et al.   MOLECULES

Discovering Anti-Cancer Drugs via Computational Methods

(2020) Wenqiang Cui et al.   Frontiers in Pharmacology

Novel 2-(2-hydrazinyl)thiazole derivatives as chemotherapeutic agents

(2020) Leyla Yurttaş et al.   SYNTHETIC COMMUNICATIONS

A liposomal FRET assay identifies potent drug‐like inhibitors of the ceramide transport protein CERT

(2020) Doaa Samaha et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers

(2020) Noha H. Amin et al.   BIOORGANIC CHEMISTRY

Novel Papaverine Metal Complexes with Potential Anticancer Activities

(2020) Ahmed Gaber et al.   MOLECULES

Review of the synthesis and biological activity of thiazoles

(2020) Sukinah H. Ali et al.   SYNTHETIC COMMUNICATIONS

Breast Cancer Treatment

(2019) Adrienne G. Waks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Thiazole in the targeted anticancer drug discovery

(2019) Adileh Ayati et al.   Future Medicinal Chemistry

Breast cancer

(2019) Nadia Harbeck et al.   Nature Reviews Disease Primers

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

(2019) Filimonov et al.   MOLECULES

Thiazole-containing compounds as therapeutic targets for cancer therapy

(2019) Prabodh Chander Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and characterization of some atypical sphingoid bases

(2018) Essa M. Saied et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, anticancer activity and mechanism of action of new thiazole derivatives

(2018) Temístocles Italo de Santana et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Analysis of US FDA-Approved Drugs Containing Sulfur Atoms

(2018) Kevin A. Scott et al.   Topics in Current Chemistry

Recent Advances in the Treatment of Breast Cancer

(2018) Christy W. S. Tong et al.   Frontiers in Oncology

A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery

(2018) Piyush N. Kalaria et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors

(2018) Jason G. Kettle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microwave-assisted and thermal synthesis of nanosized thiazolyl-phenothiazine derivatives and their biological activities

(2018) Manal M. Alsharekh et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models

(2018) A.L. Zakharenko et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016)

(2017) Fan-Wei Peng et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

VEGFR-2 inhibitors and apoptosis inducers: synthesis and molecular design of new benzo[g]quinazolin bearing benzenesulfonamide moiety

(2017) Mostafa M. Ghorab et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity

(2017) Maolin Sun et al.   PLoS One

1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation

(2016) Sahar M. Abou-Seri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Modern advances in heterocyclic chemistry in drug discovery

(2016) Alexandria P. Taylor et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The novel VEGF receptor 2 inhibitor YLL545 inhibits angiogenesis and growth in breast cancer

(2016) Jianbo Zhang et al.   Oncotarget

Design, synthesis, optimization and antiviral activity of a class of hybrid dengue virus E protein inhibitors

(2015) Surender Singh Jadav et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A series of ceramide analogs modified at the 1-position with potent activity against the intracellular growth of Chlamydia trachomatis

(2015) Essa M Saied et al.   Future Medicinal Chemistry

Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile

(2015) KENGO KURODA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis

(2015) Guido Bold et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expression and prognostic significance of VEGFR-2 in breast cancer

(2015) Ji-Dong Yan et al.   PATHOLOGY RESEARCH AND PRACTICE

Improved Plaque Assay Identifies a Novel Anti-Chlamydia Ceramide Derivative with Altered Intracellular Localization

(2014) Sebastian Banhart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors

(2014) Daniela Secci et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Facile Synthesis of the CERT Inhibitor HPA-12 and Some Novel Derivatives

(2014) Essa M. Saied et al.   Chemistry-An Asian Journal

The Synthesis and Antiproliferative Activities of New Arylidene-Hydrazinyl-Thiazole Derivatives

(2014) Adriana Grozav et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vitro and in silico antimalarial activity of 2-(2-hydrazinyl)thiazole derivatives

(2013) Parameshwar Makam et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Heterocycles 27. Microwave Assisted Synthesis and Antitumour Activity of Novel Phenothiazinyl-Thiazolyl-Hydrazine Derivatives

(2012) Adriana Ignat et al.   ARCHIV DER PHARMAZIE

Structure-Based Design of Novel Class II c-Met Inhibitors: 1. Identification of Pyrazolone-Based Derivatives

(2012) Mark H. Norman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of Novel DFG-Out RAF/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Inhibitors. 1. Exploration of [5,6]-Fused Bicyclic Scaffolds

(2012) Masanori Okaniwa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

(2012) M. McTigue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases

(2012) Hidehisa Iwata et al.   ACS Medicinal Chemistry Letters

Mechanisms of estrogen receptor-α upregulation in breast cancers

(2011) Yasuo Miyoshi et al.   Medical Molecular Morphology

Efficient one-pot three-component synthesis of N-(4-arylthiazol-2-yl) hydrazones in water under ultrasound irradiation

(2011) Dong-Nuan Zhang et al.   ULTRASONICS SONOCHEMISTRY

Vascular endothelial growth factor receptor-2 in breast cancer

(2010) Shanchun Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: Novel VEGFR2 kinase inhibitors binding to inactive kinase conformation

(2010) Yuya Oguro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of some p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles and their anticancer activity

(2010) Valentin Zaharia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Spectroscopic and Thermal Studies of Mn(II), Fe(III), Cr(III) and Zn(II) Complexes Derived from the Ligand Resulted by the Reaction Between 4-Acetyl Pyridine and Thiosemicarbazide

(2009) Moamen S. Refat et al.   Journal of Inorganic and Organometallic Polymers and Materials

BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy

(2008) F. Hilberg et al.   CANCER RESEARCH

High levels of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, neuropilin-1) are associated with worse outcome in breast cancer

(2008) Sriparna Ghosh et al.   HUMAN PATHOLOGY

A Novel Histone Acetyltransferase Inhibitor Modulating Gcn5 Network: Cyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl)hydrazone

(2008) Franco Chimenti et al.   JOURNAL OF MEDICINAL CHEMISTRY