A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19

Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19

(2021) Joydeb Majumder et al.   AAPS Journal

Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro

(2021) Hongbo Liu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBV152: a double-blind, randomised, phase 1 trial

(2021) Raches Ella et al.   LANCET INFECTIOUS DISEASES

Pilot trial of high-dose vitamin C in critically ill COVID-19 patients

(2021) Jing Zhang et al.   Annals of Intensive Care

Recombinant protein vaccines, a proven approach against coronavirus pandemics

(2021) Jeroen Pollet et al.   ADVANCED DRUG DELIVERY REVIEWS

Summary of the Available Molecular Methods for Detection of SARS-CoV-2 during the Ongoing Pandemic

(2021) Fabio Arena et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

(2021) Denis Y Logunov et al.   LANCET

Sputnik V COVID-19 vaccine candidate appears safe and effective

(2021) Ian Jones et al.   LANCET

Novavax offers first evidence that COVID vaccines protect people against variants

(2021) Ewen Callaway et al.   NATURE

Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro

(2021) Martina Morokutti-Kurz et al.   PLoS One

A preliminary report of a randomized controlled phase 2 trial of the safety and immunogenicity of mRNA-1273 SARS-CoV-2 vaccine

(2021) Laurence Chu et al.   VACCINE

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

(2021) Shin-ichiro Hattori et al.   Nature Communications

Upregulated IL-6 Indicates a Poor COVID-19 Prognosis: A Call for Tocilizumab and Convalescent Plasma Treatment

(2021) Jian Wu et al.   Frontiers in Immunology

Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives

(2021) Karthik Vivekanandhan et al.   Frontiers in Molecular Biosciences

In silico screening of potent bioactive compounds from honeybee products against COVID-19 target enzymes

(2021) Moataz A. Shaldam et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Lectins purified from medicinal and edible mushrooms: Insights into their antiviral activity against pathogenic viruses

(2021) Yousra A. El-Maradny et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Identifying structural–functional analogue of GRL0617, the only well-established inhibitor for papain-like protease (PLpro) of SARS-CoV2 from the pool of fungal metabolites using docking and molecular dynamics simulation

(2021) Priyashi Rao et al.   MOLECULAR DIVERSITY

Algae-Derived Bioactive Molecules for the Potential Treatment of SARS-CoV-2

(2021) Md. Asraful Alam et al.   MOLECULES

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

(2021) Nikola Gligorijević et al.   MOLECULES

Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19

(2021) Jerald Sadoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glycyrrhizin Effectively Inhibits SARS-CoV-2 Replication by Inhibiting the Viral Main Protease

(2021) Lukas van de Sand et al.   Viruses-Basel

Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies

(2021) Murtala Bello Abubakar et al.   Frontiers in Pharmacology

Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase

(2021) Keivan Zandi et al.   Microorganisms

Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate

(2021) Raya Soltane et al.   Pathogens

In silico investigation on the inhibitory effect of fungal secondary metabolites on RNA dependent RNA polymerase of SARS-CoV-II: A docking and molecular dynamic simulation study

(2021) Kosar Sadat Ebrahimi et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Ganoderma lucidum: A potential source to surmount viral infections through β-glucans immunomodulatory and triterpenoids antiviral properties

(2021) Md Faruque Ahmad et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial

(2021) Shipo Wu et al.   LANCET INFECTIOUS DISEASES

Griffithsin and Carrageenan Combination Results in Antiviral Synergy against SARS-CoV-1 and 2 in a Pseudoviral Model

(2021) Sahar Alsaidi et al.   Marine Drugs

In silico analysis and identification of antiviral coumarin derivatives against 3-chymotrypsin-like main protease of the novel coronavirus SARS-CoV-2

(2021) Rahman Abdizadeh et al.   MOLECULAR DIVERSITY

Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay

(2021) Woo Dae Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting Mpro and Ameliorates Pulmonary Inflammation

(2021) Ting Xiao et al.   Frontiers in Pharmacology

Recent updates on immunological, pharmacological, and alternative approaches to combat COVID-19

(2021) Ammara Saleem et al.   INFLAMMOPHARMACOLOGY

Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial

(2021) Francesco Di Pierro et al.   International Journal of General Medicine

Cell entry by SARS-CoV-2

(2021) Ruchao Peng et al.   TRENDS IN BIOCHEMICAL SCIENCES

A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors

(2020) Sukhvir Kaur et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

(2020) Victor M Corman et al.   Eurosurveillance

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

(2020) Chih-Cheng Lai et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

(2020) Clark D Russell et al.   LANCET

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study

(2020) Joseph T Wu et al.   LANCET

Convalescent plasma as a potential therapy for COVID-19

(2020) Long Chen et al.   LANCET INFECTIOUS DISEASES

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Therapeutic potential of algal natural products against metabolic syndrome: A review of recent developments

(2020) Ilekuttige Priyan Shanura Fernando et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

U1 snRNP regulates cancer cell migration and invasion in vitro

(2020) Jung-Min Oh et al.   Nature Communications

Coronavirus (COVID-19) Outbreak: What the Department of Radiology Should Know

(2020) Soheil Kooraki et al.   Journal of the American College of Radiology

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms

(2020) Abdul Mannan Baig et al.   ACS Chemical Neuroscience

Continuous hydroxychloroquine or colchicine therapy does not prevent infection with SARS-CoV-2: Insights from a large healthcare database analysis

(2020) Omer Gendelman et al.   AUTOIMMUNITY REVIEWS

Structural basis for RNA replication by the SARS-CoV-2 polymerase

(2020) Quan Wang et al.   CELL

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)

(2020) Li Guo et al.   CLINICAL INFECTIOUS DISEASES

The COVID-19 Pandemic, Small-Scale Fisheries and Coastal Fishing Communities

(2020) Nathan J. Bennett et al.   COASTAL MANAGEMENT

Pathogenesis of COVID-19 from a cell biology perspective

(2020) Robert J. Mason   EUROPEAN RESPIRATORY JOURNAL

Rethinking the role of hydroxychloroquine in the treatment of COVID‐19

(2020) Eric A. Meyerowitz et al.   FASEB JOURNAL

A Review of Coronavirus Disease-2019 (COVID-19)

(2020) Tanu Singhal   INDIAN JOURNAL OF PEDIATRICS

Pharmacological perspective: glycyrrhizin may be an efficacious therapeutic agent for COVID-19

(2020) Pan Luo et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Identification of phytochemical inhibitors against main protease of COVID-19 using molecular modeling approaches

(2020) Anuj Kumar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Coronavirus Disease 19 (COVID-19): Implications for Clinical Dental Care

(2020) Amber Ather et al.   JOURNAL OF ENDODONTICS

Glycyrrhetinic acid and its derivatives as potential alternative medicine to relieve symptoms in non‐hospitalized COVID‐19 patients

(2020) Hong Ding et al.   JOURNAL OF MEDICAL VIROLOGY

The Comparative Analysis of Antiviral Activity of Native and Modified Fucoidans from Brown Algae Fucus evanescens In Vitro and In Vivo

(2020) Natalya V. Krylova et al.   Marine Drugs

Mechanisms of Bioactivities of Fucoidan from the Brown Seaweed Fucus vesiculosus L. of the Barents Sea

(2020) Olga N. Pozharitskaya et al.   Marine Drugs

Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses

(2020) Nakarin Suwannarach et al.   MOLECULES

Structure of replicating SARS-CoV-2 polymerase

(2020) Hauke S. Hillen et al.   NATURE

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Developing Covid-19 Vaccines at Pandemic Speed

(2020) Nicole Lurie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

A critical review: traditional uses, phytochemistry, pharmacology and toxicology of Stephania tetrandra S. Moore (Fen Fang Ji)

(2020) Yueping Jiang et al.   PHYTOCHEMISTRY REVIEWS

Cytokine release syndrome in severe COVID-19

(2020) John B. Moore et al.   SCIENCE

Development of a Portable, Ultra-Rapid and Ultra-Sensitive Cell-Based Biosensor for the Direct Detection of the SARS-CoV-2 S1 Spike Protein Antigen

(2020) Sophie Mavrikou et al.   SENSORS

Collecting and evaluating convalescent plasma for COVID‐19 treatment: why and how?

(2020) Pierre Tiberghien et al.   VOX SANGUINIS

Vitamin D Supplementation in Influenza and COVID-19 Infections Comment on: “Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths” Nutrients 2020, 12(4), 988

(2020) Chia Siang Kow et al.   Nutrients

Generation of gene-corrected functional osteoclasts from osteopetrotic induced pluripotent stem cells

(2020) Xiaojie Xian et al.   Stem Cell Research & Therapy

Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants

(2020) Muhammad Tahir ul Qamar et al.   Journal of Pharmaceutical Analysis

Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients

(2020) Hai-xia Su et al.   ACTA PHARMACOLOGICA SINICA

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

(2020) Yuan Huang et al.   ACTA PHARMACOLOGICA SINICA

Coronavirus membrane fusion mechanism offers a potential target for antiviral development

(2020) Tiffany Tang et al.   ANTIVIRAL RESEARCH

Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening

(2020) Olga Abian et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation

(2020) Elena Campione et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Screening of phytochemical compounds of Tinospora cordifolia for their inhibitory activity on SARS-CoV-2: an in silico study

(2020) S. Krupanidhi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis

(2020) Leiwen Fu et al.   JOURNAL OF INFECTION

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

p38 MAPK inhibition: A promising therapeutic approach for COVID-19

(2020) Joseph M. Grimes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease

(2020) Mahmoud Kandeel et al.   LIFE SCIENCES

Six months of coronavirus: the mysteries scientists are still racing to solve

(2020) Ewen Callaway et al.   NATURE

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

(2020) Laura Riva et al.   NATURE

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

(2020) Mark J. Mulligan et al.   NATURE

Dexamethasone nanomedicines for COVID-19

(2020) Twan Lammers et al.   Nature Nanotechnology

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19)

(2020) Fangfang Huang et al.   PHARMACOLOGICAL RESEARCH

Bioconversion of a ganoderic acid 3-hydroxy-lanosta-8,24-dien-26-oic acid by a crude enzyme from Ganoderma lucidum

(2020) Siqin Cai et al.   PROCESS BIOCHEMISTRY

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

(2020) Ching-Lin Hsieh et al.   SCIENCE

Treatment for emerging viruses: Convalescent plasma and COVID-19

(2020) Bethany L. Brown et al.   TRANSFUSION AND APHERESIS SCIENCE

Repurposing Therapeutics for Potential Treatment of SARS-CoV-2: A Review

(2020) Jennifer Santos et al.   Viruses-Basel

SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses

(2020) He-wei Jiang et al.   Nature Communications

Evidence does not support vitamin D for reducing respiratory infections, reviews conclude

(2020) Ingrid Torjesen   BMJ-British Medical Journal

Medicinal Plants as Sources of Active Molecules Against COVID-19

(2020) Bachir Benarba et al.   Frontiers in Pharmacology

Anti-SARS-CoV-2 Potential of Artemisinins In Vitro

(2020) Ruiyuan Cao et al.   ACS Infectious Diseases

Role of vitamin D in preventing of COVID-19 infection, progression and severity

(2020) Nurshad Ali   Journal of Infection and Public Health

Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro

(2020) Paul S. Kwon et al.   Cell Discovery

SARS-CoV-2: An Update on Potential Antivirals in Light of SARS-CoV Antiviral Drug Discoveries

(2020) Hatem A. Elshabrawy   Vaccines

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

(2020) Farhana Rumzum Bhuiyan et al.   Frontiers in Medicine

Geranium and Lemon Essential Oils and Their Active Compounds Downregulate Angiotensin-Converting Enzyme 2 (ACE2), a SARS-CoV-2 Spike Receptor-Binding Domain, in Epithelial Cells

(2020) K. J. Senthil Kumar et al.   Plants-Basel

Potential of DNA Intercalating Alkaloids and Other Plant Secondary Metabolites against SARS-CoV-2 Causing COVID-19

(2020) Michael Wink   Diversity-Basel

Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines

(2020) Lin Ang et al.   Integrative Medicine Research

Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach

(2020) Ahmad Abu Turab Naqvi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Strategies and perspectives to develop SARS-CoV-2 detection methods and diagnostics

(2020) Rekha Jalandra et al.   BIOMEDICINE & PHARMACOTHERAPY

Reckoning a fungal metabolite, Pyranonigrin A as a potential Main protease (Mpro) inhibitor of novel SARS-CoV-2 virus identified using docking and molecular dynamics simulation

(2020) Priyashi Rao et al.   BIOPHYSICAL CHEMISTRY

Expansion of SARS-CoV-2–Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients

(2020) Renata Varnaitė et al.   JOURNAL OF IMMUNOLOGY

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

(2020) Robert L. Hoffman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial

(2020) Shengli Xia et al.   LANCET INFECTIOUS DISEASES

SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging

(2020) Wioletta Rut et al.   Nature Chemical Biology

A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations

(2020) Ludivine Grzelak et al.   Science Translational Medicine

Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease

(2020) Lifeng Fu et al.   Nature Communications

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

(2020) Alice Douangamath et al.   Nature Communications

Alkaloids from Cryptolepis sanguinolenta as Potential Inhibitors of SARS-CoV-2 Viral Proteins: An In Silico Study

(2020) Lawrence Sheringham Borquaye et al.   Biomed Research International

A Review of the Progress and Challenges of Developing a Vaccine for COVID-19

(2020) Omna Sharma et al.   Frontiers in Immunology

SARS-CoV-2 Proteome Microarray for Mapping COVID-19 Antibody Interactions at Amino Acid Resolution

(2020) Hongye Wang et al.   ACS Central Science

Crystal structure of SARS-CoV-2 papain-like protease

(2020) Xiaopan Gao et al.   Acta Pharmaceutica Sinica B

The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic

(2020) Jung-Hyun Won et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunologic testing for SARS-CoV-2 infection from the antigen perspective

(2020) Dandan Li et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Promising terpenes as SARS-CoV-2 spike receptor-binding domain (RBD) attachment inhibitors to the human ACE2 receptor: Integrated computational approach

(2020) Ziyad Tariq Muhseen et al.   JOURNAL OF MOLECULAR LIQUIDS

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

(2020) Merryn Voysey et al.   LANCET

The Role of Vitamin C, Vitamin D, and Selenium in Immune System against COVID-19

(2020) Minkyung Bae et al.   MOLECULES

Novel Papaverine Metal Complexes with Potential Anticancer Activities

(2020) Ahmed Gaber et al.   MOLECULES

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2

(2020) Wael H. Roshdy et al.   PLoS One

Molecular interaction analysis of Sulawesi propolis compounds with SARS-CoV-2 main protease as preliminary study for COVID-19 drug discovery

(2020) Muhamad Sahlan et al.   JOURNAL OF KING SAUD UNIVERSITY SCIENCE

Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections

(2020) Keneth Iceland Kasozi et al.   Frontiers in Public Health

Immunomodulatory activities of polysaccharides from Ganoderma on immune effector cells

(2020) Li Ren et al.   FOOD CHEMISTRY

TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

(2019) Naoko Iwata-Yoshikawa et al.   JOURNAL OF VIROLOGY

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

(2019) Harri Hemilä et al.   Nutrients

Ursodeoxycholic acid stimulates alveolar fluid clearance in LPS‐induced pulmonary edema via ALX/cAMP/PI3K pathway

(2019) Fangfang Niu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus

(2019) Alaa M. H. El-Bitar et al.   International Journal of Peptide Research and Therapeutics

Mannose-Specific Lectins from Marine Algae: Diverse Structural Scaffolds Associated to Common Virucidal and Anti-Cancer Properties

(2019) Annick Barre et al.   Marine Drugs

Structural basis for human coronavirus attachment to sialic acid receptors

(2019) M. Alejandra Tortorici et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Improving therapy of severe infections through drug repurposing of synergistic combinations

(2019) Yu-Shan Cheng et al.   CURRENT OPINION IN PHARMACOLOGY

Mediterranean products as promising source of multi-target agents in the treatment of metabolic syndrome

(2019) Donatella Bagetta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cytotoxic Effects of Smp24 and Smp43 Scorpion Venom Antimicrobial Peptides on Tumour and Non-tumour Cell Lines

(2019) Ranwa A. Elrayess et al.   International Journal of Peptide Research and Therapeutics

Should we be performing metagenomic next-generation sequencing for infectious disease diagnosis in the clinical laboratory?

(2019) Steve Miller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Inhibition of SARS-CoV 3CL protease by flavonoids

(2019) Seri Jo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Nucleocapsid protein recruitment to replication-transcription complexes plays a crucial role in coronaviral life cycle

(2019) Yingying Cong et al.   JOURNAL OF VIROLOGY

Griffithsin, a Highly Potent Broad-Spectrum Antiviral Lectin from Red Algae: From Discovery to Clinical Application

(2019) Lee   Marine Drugs

Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake

(2019) Brody Mallard et al.   PLoS One

The human coronavirus HCoV‐229E S‐protein structure and receptor binding

(2019) Zhijie Li et al.   eLife

Synthesis of Swinhoeisterol A, Dankasterone A and B, and Periconiastone A by Radical Framework Reconstruction

(2019) Fenja L. Duecker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials

(2019) Gonçalo P. Rosa et al.   Marine Drugs

Effect of interferon alpha and cyclosporine treatment separately and in combination on Middle East Respiratory Syndrome Coronavirus (MERS-CoV) replication in a human in-vitro and ex-vivo culture model

(2018) H.S. Li et al.   ANTIVIRAL RESEARCH

Molecular dynamics of Middle East Respiratory Syndrome Coronavirus (MERS CoV) fusion heptad repeat trimers

(2018) Mahmoud Kandeel et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Antioxidant and anti-inflammatory functionality of ten Sri Lankan seaweed extracts obtained by carbohydrase assisted extraction

(2018) I. P. Shanura Fernando et al.   FOOD SCIENCE AND BIOTECHNOLOGY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

TISSUES 2.0: an integrative web resource on mammalian tissue expression

(2018) Oana Palasca et al.   Database-The Journal of Biological Databases and Curation

Overexpression of the nucleocapsid protein of Middle East Respiratory Syndrome coronavirus up-regulates CXCL10

(2018) James Odame Aboagye et al.   BIOSCIENCE REPORTS

Fungal immunomodulatory proteins: characteristic, potential antitumor activities and their molecular mechanisms

(2018) Qi-Zhang Li et al.   DRUG DISCOVERY TODAY

Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

(2018) Robert N. Kirchdoerfer et al.   Scientific Reports

Comprehensive review of antimicrobial activities of plant flavonoids

(2018) Ireneusz Górniak et al.   PHYTOCHEMISTRY REVIEWS

Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein

(2018) Hannah Kleine-Weber et al.   Scientific Reports

The Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-I Interferon Response

(2018) Zhenglin Ji et al.   VIROLOGICA SINICA

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

(2017) Elena Bekerman et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors

(2017) Ji-Young Park et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase

(2017) Yousuke FURUTA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

(2017) Yuan Yuan et al.   Nature Communications

Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin

(2016) Jean K. Millet et al.   ANTIVIRAL RESEARCH

Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding

(2016) Miao Gui et al.   CELL RESEARCH

Optimized Virtual Screening Workflow for the Identification of Novel G-Quadruplex Ligands

(2016) Teresa Kaserer et al.   Journal of Chemical Information and Modeling

An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

(2016) Thanigaimalai Pillaiyar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor

(2016) Wenjuan Wang et al.   PLoS One

Family-wide Structural Analysis of Human Numb-Associated Protein Kinases

(2016) Fiona J. Sorrell et al.   STRUCTURE

Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection

(2016) K.H. Chiow et al.   Asian Pacific Journal of Tropical Medicine

Anti-rheumatoid Activity of Secondary Metabolites Produced by Endophytic Chaetomium globosum

(2016) Ahmed M. Abdel-Azeem et al.   Frontiers in Microbiology

Baicalin attenuates angiotensin II-induced endothelial dysfunction

(2015) Xiling Wei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Snapshots of scorpion venomics

(2015) Mohamed A. Abdel-Rahman et al.   JOURNAL OF ARID ENVIRONMENTS

Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design

(2015) Qinchang Zhu et al.   Scientific Reports

Structures of theMiddle East respiratory syndrome coronavirus3C-like protease reveal insights into substrate specificity

(2015) Danielle Needle et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

(2014) Rolf Hilgenfeld   FEBS Journal

What is the potential of structure-based target prediction methods?

(2014) Karen T Schomburg et al.   Future Medicinal Chemistry

Structure-Based Virtual Screening of Novel Natural Alkaloid Derivatives as Potential Binders of h-telo and c-myc DNA G-Quadruplex Conformations

(2014) Roberta Rocca et al.   MOLECULES

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1

(2013) Wei Hong et al.   ANTIVIRAL RESEARCH

Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus

(2013) Wei Hong et al.   BIOMATERIALS

Dieckol, a SARS-CoV 3CLpro inhibitor, isolated from the edible brown algae Ecklonia cava

(2013) Ji-Young Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa

(2013) Jung Keun Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Immobilisation and application of lipases in organic media

(2013) Patrick Adlercreutz   CHEMICAL SOCIETY REVIEWS

Adjuvant Treatment With a Mammalian Target of Rapamycin Inhibitor, Sirolimus, and Steroids Improves Outcomes in Patients With Severe H1N1 Pneumonia and Acute Respiratory Failure*

(2013) Chun-Hua Wang et al.   CRITICAL CARE MEDICINE

Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds ofPsoralea corylifolia

(2013) Dae Wook Kim et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies

(2013) S. Gierer et al.   JOURNAL OF VIROLOGY

Venom proteomic and venomous glands transcriptomic analysis of the Egyptian scorpion Scorpio maurus palmatus (Arachnida: Scorpionidae)

(2013) Mohamed A. Abdel-Rahman et al.   TOXICON

MERS-CoV papain-like protease has deISGylating and deubiquitinating activities

(2013) Anna M. Mielech et al.   VIROLOGY

Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation

(2013) Marcel Tutor Ale et al.   RSC Advances

The newly emerged SARS-Like coronavirus HCoV-EMC also has an “Achilles’ heel”: current effective inhibitor targeting a 3C-like protease

(2013) Zhilin Ren et al.   Protein & Cell

Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13

(2012) Mi-Sun Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dihydroartemisinin/Piperaquine

(2012) Gillian M. Keating   DRUGS

Inactivated virus vaccines from chemistry to prophylaxis: merits, risks and challenges

(2012) Iris Delrue et al.   Expert Review of Vaccines

A facile inhibitor screening of SARS coronavirus N protein using nanoparticle-based RNA oligonucleotide

(2012) Changhyun Roh   International Journal of Nanomedicine

Mucroporin-M1 Inhibits Hepatitis B Virus Replication by Activating the Mitogen-activated Protein Kinase (MAPK) Pathway and Down-regulating HNF4αin Vitroandin Vivo

(2012) Zhenhuan Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-HIV-1 Activity of a New Scorpion Venom Peptide Derivative Kn2-7

(2012) Yaoqing Chen et al.   PLoS One

Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506

(2012) Javier Carbajo-Lozoya et al.   VIRUS RESEARCH

Cyclosporin A inhibits the replication of diverse coronaviruses

(2011) A. H. de Wilde et al.   JOURNAL OF GENERAL VIROLOGY

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Triterpene Functional Genomics in Licorice for Identification of CYP72A154 Involved in the Biosynthesis of Glycyrrhizin

(2011) Hikaru Seki et al.   PLANT CELL

Different Origins of Gamma Rhythm and High-Gamma Activity in Macaque Visual Cortex

(2011) Supratim Ray et al.   PLOS BIOLOGY

Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus

(2010) Li-En Hsieh et al.   ANTIVIRAL RESEARCH

Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition

(2010) Young Bae Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A new natural α-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV

(2010) Ran Yan et al.   PEPTIDES

Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection

(2009) Min Zhuang et al.   ANTIVIRAL RESEARCH

Pilot clinical study to evaluate the anticoagulant activity of fucoidan

(2009) Mohammad R Irhimeh et al.   BLOOD COAGULATION & FIBRINOLYSIS

HIV protease inhibitors: recent clinical trials and recommendations on use

(2009) José Vicente Fernández-Montero et al.   EXPERT OPINION ON PHARMACOTHERAPY

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

(2009) B. R. O'Keefe et al.   JOURNAL OF VIROLOGY

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY

Cryo-electron tomography of mouse hepatitis virus: Insights into the structure of the coronavirion

(2009) M. Barcena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor

(2009) K. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological Effects of Yeast- and Mushroom-Derived β-Glucans

(2008) Vaclav Vetvicka et al.   JOURNAL OF MEDICINAL FOOD

Melissa officinalis oil affects infectivity of enveloped herpesviruses

(2008) P. Schnitzler et al.   PHYTOMEDICINE

Antimicrobial Activity of Pyrrocidines fromAcremonium zeaeAgainst Endophytes and Pathogens of Maize

(2008) Donald T. Wicklow et al.   PHYTOPATHOLOGY

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

(2008) K. Ratia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iota-Carrageenan is a potent inhibitor of rhinovirus infection

(2008) Andreas Grassauer et al.   Virology Journal