AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay

Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay

(2021) Tatsuaki Kurosaki et al.   NATURE CELL BIOLOGY

A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies

(2021) Yunhee Kang et al.   NATURE NEUROSCIENCE

SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity

(2021) Volker Boehm et al.   Nature Communications

A role for AKT1 in nonsense-mediated mRNA decay

(2021) Martine Palma et al.   NUCLEIC ACIDS RESEARCH

Developmental studies in fragile X syndrome

(2020) Khaleel A. Razak et al.   Journal of Neurodevelopmental Disorders

Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum

(2020) Dasa Longman et al.   GENES & DEVELOPMENT

The RNA-binding protein PTBP1 promotes ATPase-dependent dissociation of the RNA helicase UPF1 to protect transcripts from nonsense-mediated mRNA decay

(2020) Sarah E. Fritz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex

(2020) Jennifer V Gerbracht et al.   NUCLEIC ACIDS RESEARCH

Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3ʹ UTR-Directed Regulation and Nonsense-Mediated Decay

(2020) Xiaoqiang Zhu et al.   Cell Reports

A Day in the Life of the Exon Junction Complex

(2020) Lena P. Schlautmann et al.   Biomolecules

The Branched Nature of the Nonsense-Mediated mRNA Decay Pathway

(2020) Zhongxia Yi et al.   TRENDS IN GENETICS

UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond

(2019) Yoon Ki Kim et al.   RNA

Reference Gene Validation via RT–qPCR for Human iPSC-Derived Neural Stem Cells and Neural Progenitors

(2019) Justyna Augustyniak et al.   MOLECULAR NEUROBIOLOGY

Quality and quantity control of gene expression by nonsense-mediated mRNA decay

(2019) Tatsuaki Kurosaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nonsense‐mediated mRNA decay: The challenge of telling right from wrong in a complex transcriptome

(2019) Aparna Kishor et al.   Wiley Interdisciplinary Reviews-RNA

Nonsense-mediated mRNA Decay and Cancer

(2018) Maximilian W Popp et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression

(2018) Hana Cho et al.   GENES & DEVELOPMENT

Protein synthesis levels are increased in a subset of individuals with fragile X syndrome

(2018) Sébastien Jacquemont et al.   HUMAN MOLECULAR GENETICS

A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner

(2018) Manjeera Gowravaram et al.   NUCLEIC ACIDS RESEARCH

Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression

(2018) Sofia Nasif et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ICE1 promotes the link between splicing and nonsense-mediated mRNA decay

(2018) Thomas D Baird et al.   eLife

The Exon Junction Complex Undergoes a Compositional Switch that Alters mRNP Structure and Nonsense-Mediated mRNA Decay Activity

(2018) Justin W. Mabin et al.   Cell Reports

Fluorescence Amplification Method for Forward Genetic Discovery of Factors in Human mRNA Degradation

(2017) Andrei Alexandrov et al.   MOLECULAR CELL

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling

(2017) Markus Brockmann et al.   NATURE

PLA2G16 represents a switch between entry and clearance of Picornaviridae

(2017) Jacqueline Staring et al.   NATURE

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells

(2017) Yuchen Qi et al.   NATURE BIOTECHNOLOGY

Vasohibins encode tubulin detyrosinating activity

(2017) Joppe Nieuwenhuis et al.   SCIENCE

Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells

(2017) Masayuki Yamaji et al.   Cancer Medicine

IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation

(2017) Gina Dörpholz et al.   Scientific Reports

Insulin Signaling Augments eIF4E-Dependent Nonsense-Mediated mRNA Decay in Mammalian Cells

(2016) Jungyun Park et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Lovastatin corrects ERK pathway hyperactivation in fragile X syndrome: potential of platelet’s signaling cascades as new outcome measures in clinical trials

(2016) David Pellerin et al.   BIOMARKERS

Is There a Future for AKT Inhibitors in the Treatment of Cancer?

(2016) V. M. Jansen et al.   CLINICAL CANCER RESEARCH

Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay

(2016) Sébastien Durand et al.   Nature Communications

Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway

(2016) Zhiyun Ge et al.   eLife

Nonsense-Mediated RNA Decay Influences Human Embryonic Stem Cell Fate

(2016) Chih-Hong Lou et al.   Stem Cell Reports

Caspases shutdown nonsense-mediated mRNA decay during apoptosis

(2015) J Jia et al.   CELL DEATH AND DIFFERENTIATION

Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay

(2015) T. Li et al.   EMBO JOURNAL

The unfolded protein response is shaped by the NMD pathway

(2015) R. Karam et al.   EMBO REPORTS

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

(2015) GEORGE MIHAI NITULESCU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity

(2015) Suzanne R. Lee et al.   MOLECULAR CELL

Gene essentiality and synthetic lethality in haploid human cells

(2015) V. A. Blomen et al.   SCIENCE

Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics

(2015) Maximilian W. Popp et al.   Nature Communications

A post-translational regulatory switch on UPF1 controls targeted mRNA degradation

(2014) Tatsuaki Kurosaki et al.   GENES & DEVELOPMENT

Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels

(2014) Philipp Mertins et al.   MOLECULAR & CELLULAR PROTEOMICS

Intracellular calcium regulates nonsense-mediated mRNA decay

(2014) Andrew Nickless et al.   NATURE MEDICINE

Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6

(2014) Sutapa Chakrabarti et al.   NUCLEIC ACIDS RESEARCH

A kinase-independent function of AKT promotes cancer cell survival

(2014) Igor Vivanco et al.   eLife

Regulation of nonsense-mediated mRNA decay: Implications for physiology and disease

(2013) Rachid Karam et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

mTOR complex 2 mediates Akt phosphorylation that requires PKCε in adult cardiac muscle cells

(2013) Phillip C. Moschella et al.   CELLULAR SIGNALLING

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2

(2013) B. Loh et al.   GENES & DEVELOPMENT

DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans

(2013) Dasa Longman et al.   NUCLEIC ACIDS RESEARCH

Rules that govern UPF1 binding to mRNA 3′ UTRs

(2013) Tatsuaki Kurosaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry

(2013) L. T. Jae et al.   SCIENCE

Staufen1-Mediated mRNA Decay Functions in Adipogenesis

(2012) Hana Cho et al.   MOLECULAR CELL

Unknown

(2012) Christina Gross et al.   MOLECULAR MEDICINE

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains

(2012) Francesca Fiorini et al.   NUCLEIC ACIDS RESEARCH

Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity

(2012) E. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

(2012) K. Lin et al.   Science Signaling

Inhibition of Nonsense-Mediated RNA Decay by the Tumor Microenvironment Promotes Tumorigenesis

(2011) D. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and Its Regulation by Upf2

(2011) Sutapa Chakrabarti et al.   MOLECULAR CELL

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing

(2011) Jan E Carette et al.   NATURE BIOTECHNOLOGY

Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish

(2011) Corina Anastasaki et al.   NUCLEIC ACIDS RESEARCH

Generation of iPSCs from cultured human malignant cells

(2010) J. E. Carette et al.   BLOOD

Upf1 ATPase-Dependent mRNP Disassembly Is Required for Completion of Nonsense- Mediated mRNA Decay

(2010) Tobias M. Franks et al.   CELL

Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome

(2010) C. Gross et al.   JOURNAL OF NEUROSCIENCE

Nonsense-Mediated RNA Decay Regulation by Cellular Stress: Implications for Tumorigenesis

(2010) L. B. Gardner   MOLECULAR CANCER RESEARCH

UPF1 Association with the Cap-Binding Protein, CBP80, Promotes Nonsense-Mediated mRNA Decay at Two Distinct Steps

(2010) Jungwook Hwang et al.   MOLECULAR CELL

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay

(2010) D. R. McIlwain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

(2009) Marcello Clerici et al.   EMBO JOURNAL

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

(2009) A. Yamashita et al.   GENES & DEVELOPMENT

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens

(2009) J. E. Carette et al.   SCIENCE

CD15, CD24 and CD29 Define a Surface Biomarker Code for Neural Lineage Differentiation of Stem Cells

(2009) Jan Pruszak et al.   STEM CELLS

The life of a cell: apoptosis regulation by the PI3K/PKB pathway

(2008) Vincent Duronio   BIOCHEMICAL JOURNAL

Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay

(2008) Olaf Isken et al.   CELL

Human neural progenitor cells derived from embryonic stem cells in feeder-free cultures

(2008) Sujoy K. Dhara et al.   DIFFERENTIATION

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

(2008) J. Weischenfeldt et al.   GENES & DEVELOPMENT

SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs

(2008) C. Gong et al.   GENES & DEVELOPMENT

Hypoxic Inhibition of Nonsense-Mediated RNA Decay Regulates Gene Expression and the Integrated Stress Response

(2008) L. B. Gardner   MOLECULAR AND CELLULAR BIOLOGY