Review
Veterinary Sciences
Federico Armando, Federico Mazzola, Luca Ferrari, Attilio Corradi
Summary: This review discusses the general concept of epithelial-mesenchymal transition (EMT) and its regulation by various factors. It covers the role of transcription factors, microRNAs, reactive oxygen species, exosomes, microvesicles, and viruses in EMT. The review also examines EMT in embryonic development, fibrosis, and cancer metastasis, including discussions on the tumor microenvironment, pre-metastatic niches, and cancer stem cells. Additionally, it explores the use of EMT as a prognostic marker and provides insights into mesenchymal-epithelial transition (MET) in sarcomas. Therapeutic approaches for targeting EMT and MET are also addressed.
VETERINARY SCIENCES
(2023)
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell & Tissue Engineering
Elham Ghasempour, Shilan Hesami, Elaheh Movahed, Saeed Heidari Keshel, Mohammad Doroudian
Summary: Brain tumors are a lethal type of cancer, and the blood-brain barrier presents a challenge for treatment. Mesenchymal stem cells (MSCs) and their derived exosomes show potential in treating brain tumors.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Dongli Li, Junxiu Zhang, Zijia Liu, Yuanyuan Gong, Zhi Zheng
Summary: This study revealed that exosomal miR-27b derived from hucMSCs could reverse the EMT process induced by TGF-beta 2 by inhibiting HOXC6, suggesting the potential therapeutic role of the exosomal miR-27b/HOXC6 axis in ameliorating subretinal fibrosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Xin Mao, Peng Xian, Hang You, Gang Huang, Jun Li
Summary: Cardiac allograft rejection is a significant factor in the long-term survival of heart transplant patients. The mouse heart transplantation model, due to its genetic similarity with humans, is ideal for investigating rejection mechanisms and developing approaches to improve patient outcomes.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Review
Oncology
Evan M. McCabe, Theodore P. Rasmussen
Summary: The epithelial to mesenchymal transition (EMT) is a cellular process crucial in embryogenesis, where cancer stem cells (CSCs) play a role by differentiating and undergoing EMT. Long noncoding RNAs (lncRNAs) also have a role in CSCs and EMT, with the potential to serve as biomarkers and therapeutic targets in cancer progression.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Inese Briede, Dainis Balodis, Janis Gardovskis, Ilze Strumfa
Summary: Colorectal carcinoma ranks third by incidence and second by mortality globally, with high numbers of advanced cases. Cancer stem cells present a challenge to the treatment of metastatic colorectal cancer, with intricate associations between inflammation, epithelial-mesenchymal transition, and cancer stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Juliane Strietz, Stella S. Stepputtis, Marie Follo, Peter Bronsert, Elmar Stickeler, Jochen Maurer
Summary: Primary breast cancer stem cell (BCSC) cultures isolated from TNBC specimens have been established and shown to grow as tumor spheres under anchorage-independent culture conditions in vitro, while reliably forming tumors in mice when transplanted in limiting dilutions in vivo. Additionally, these BCSC xenograft tumors exhibit similar architecture and gene expression to the original patient tumor, suggesting a promising model for researching BCSC biology and testing new treatment options for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Amanda Rose Khater, Tamara Abou-Antoun
Summary: Malignant nervous system cancers in children pose a significant challenge due to their aggressive nature and sometimes inoperable location in critical regions. The developmental processes of the nervous system during childhood further complicate treatment modalities. Pediatric oncologists are tasked with providing effective cures while navigating limited therapeutic options to minimize neurotoxicity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rachel Vazana-Netzarim, Yishay Elmalem, Shachar Sofer, Hod Bruck, Naama Danino, Udi Sarig
Summary: By seeding hMSCs on pcECM, we observed a partial mesenchymal-to-epithelial transition (MET) and identified the crucial role of HAND2 gene in this process. HAND2 and its associated non-coding RNA are expressed at different levels in various tissues, and deviation from these basal levels is associated with various pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Kaibo Guo, Yuqian Feng, Xueer Zheng, Leitao Sun, Harpreet S. Wasan, Shanming Ruan, Minhe Shen
Summary: Resveratrol and its analogs can reverse EMT through diverse mechanisms, inhibit tumor invasion and migration, potentially serving as novel anti-tumor agents. They can also reverse chemoresistance and improve the antiproliferative effects of conventional treatments.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tong Gao, Xu Yang, Masayoshi Fujisawa, Toshiaki Ohara, Tianyi Wang, Nahoko Tomonobu, Masakiyo Sakaguchi, Teizo Yoshimura, Akihiro Matsukawa
Summary: The downregulation of SPRED2 promotes EMT and stemness in hepatocellular carcinoma through the activation of the ERK1/2 pathway, leading to more malignant phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
So Yoon Ahn, Dong Kyung Sung, Yun Sil Chang, Se In Sung, Young Eun Kim, Hyo-Jin Kim, Soon Min Lee, Won Soon Park
Summary: The study suggests that irradiated BDNF-eMSCs outperform naive MSCs in attenuating severe hypoxic ischemic brain injury, showing better paracrine potency and therapeutic efficacy by reducing cytotoxicity, oxidative stress, cell death, brain injury progression, apoptotic cell death, astrogliosis, inflammatory responses, and impaired motor function. The findings indicate that BDNF gene-transfected MSCs may offer a more effective therapeutic strategy against severe neonatal HI brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wenli Zhou, Zhennan Yun, Ting Wang, Chao Li, Jiantao Zhang
Summary: The study reveals the critical roles of BTF3 and BMI1 in colorectal cancer, influencing the stem cell-like traits and epithelial-mesenchymal transition of CRC cells to promote or inhibit metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Agriculture, Dairy & Animal Science
Alessandro Sammarco, Chiara Gomiero, Giorgia Beffagna, Laura Cavicchioli, Silvia Ferro, Silvia Michieletto, Enrico Orvieto, Marco Patruno, Valentina Zappulli
Summary: This study investigated the expression of molecules related to epithelial-to-mesenchymal transition (EMT) in human breast cancer, canine mammary tumors, and feline mammary tumors at the gene and protein level. It was found that some typical EMT markers were not highly expressed at the mRNA level in tumors, suggesting the need for investigation of other markers. However, at the protein level, molecules such as vimentin and E-cadherin were associated with higher aggressiveness and potential usefulness as markers. The study also confirmed similarities between feline mammary tumors and triple negative breast cancer, as well as between canine mammary tumors and the less aggressive subtype of human breast cancer that expresses hormonal receptors.
Article
Biochemistry & Molecular Biology
Anna Mallach, Maria Weinert, Joy Arthur, Djordje Gveric, Travis S. Tierney, Kambiz N. Alavian
Article
Biochemistry & Molecular Biology
Maria Weinert, Aurelie Millet, Elizabeth A. Jonas, Kambiz N. Alavian
Article
Cell Biology
Rongmin Chen, Han-A Park, Nelli Mnatsakanyan, Yulong Niu, Pawel Licznerski, Jing Wu, Paige Miranda, Morven Graham, Jack Tang, Agnita J. W. Boon, Giovanni Cossu, Wim Mandemakers, Vincenzo Bonifati, Peter J. S. Smith, Kambiz N. Alavian, Elizabeth A. Jonas
CELL DEATH & DISEASE
(2019)
Article
Cell & Tissue Engineering
Vishal Menon, Ria Thomas, Claudio Elgueta, Marcus Horl, Teresia Osborn, Penny J. Hallett, Marlene Bartos, Ole Isacson, Jan Pruszak
Article
Evolutionary Biology
Yang Fang, Chengcheng Liu, Jiangyi Lin, Xufeng Li, Kambiz N. Alavian, Yi Yang, Yulong Niu
BMC EVOLUTIONARY BIOLOGY
(2019)
Review
Neurosciences
Teresia M. Osborn, Penelope J. Hallett, James M. Schumacher, Ole Isacson
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Editorial Material
Clinical Neurology
Ole Isacson
FRONTIERS IN NEUROLOGY
(2020)
Article
Neurosciences
Oeystein R. Brekk, Joanna A. Korecka, Cecile C. Crapart, Mylene Huebecker, Zachary K. MacBain, Sara Ann Rosenthal, Miguel Sena-Esteves, David A. Priestman, Frances M. Platt, Ole Isacson, Penelope J. Hallett
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Oeystein Roed Brekk, Jonathan R. Honey, Seungil Lee, Penelope J. Hallett, Ole Isacson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Medicine, Research & Experimental
Joanna A. Korecka, Ria Thomas, Anthony J. Hinrich, Alyssa M. Moskites, Zach K. Macbain, Penelope J. Hallett, Ole Isacson, Michelle L. Hastings
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Neurosciences
Ria Thomas, Elizabeth B. Moloney, Zachary K. Macbain, Penelope J. Hallett, Ole Isacson
Summary: This study demonstrates that fibroblasts from idiopathic PD patients show reduced lysosomal GCase activity due to impaired GBA protein trafficking to lysosomes, while genetic PD cells with GBA N370S mutation exhibit a different mechanism for decreased GCase activity.
Review
Biochemistry & Molecular Biology
Kerri-Lee Wallom, Maria E. Fernandez-Suarez, David A. Priestman, Danielle te Vruchte, Mylene Huebecker, Penelope J. Hallett, Ole Isacson, Frances M. Platt
Summary: Studies have shown that variants in the lysosomal glucocerebrosidase gene (GBA) are a risk factor for Parkinson's disease (PD), and variants in multiple genes linked to diseases of glycosphingolipid (GSL) metabolism are also associated with PD. This indicates the importance of GSLs in the healthy brain and how lipid imbalances and lysosomal dysfunction are related to normal ageing and neurodegenerative diseases.
GLYCOCONJUGATE JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Oliver Cooper, Penny Hallett, Ole Isacson
Summary: Brain health relies on adaptability and resetting after challenges. Neurodegeneration occurs when adaptability is restricted. Accumulation of lipids compromises adaptability in neural circuits. Treatment targeting lipid metabolism can restore adaptive homeostasis in individuals at risk of cognitive decline.
Article
Cell & Tissue Engineering
Ria Thomas, Vishal Menon, Rakesh Mani, Jan Pruszak
Summary: The neural crest gives rise to a diverse range of cell types, and studying their development can provide insights into neurocristopathies, neural cancer biology, and regenerative medicine. By culturing neural crest cells derived from stem cells, researchers have identified CD surface markers that define different stages of human neural crest development. These markers can be used to study neural crest stemness, epithelial-to-mesenchymal transition (EMT), and malignancies.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Education & Educational Research
Stefano Sandrone, Kambiz N. Alavian
Summary: Threshold concepts are established in medical education but are a new area in neuroscience education. This article reviews existing literature on threshold concepts in clinical/translational neuroscience education, emphasizing the importance of biomarkers as a new threshold concept, and provides recommendations to improve student experience and build a community of practice with shared goals and enhanced diversity for societal benefits.
FRONTIERS IN EDUCATION
(2021)
