Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration
出版年份 2022 全文链接
标题
Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration
作者
关键词
-
出版物
JOURNAL OF MEDICINAL CHEMISTRY
Volume 65, Issue 14, Pages 9548-9563
出版商
American Chemical Society (ACS)
发表日期
2022-07-08
DOI
10.1021/acs.jmedchem.2c00585
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries
- (2022) Sabine Willems et al. ChemMedChem
- Nurr1 Modulation Mediates Neuroprotective Effects of Statins
- (2022) Sabine Willems et al. Advanced Science
- Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1
- (2021) Yongwoo Jang et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms
- (2021) Sabine Willems et al. JOURNAL OF MEDICINAL CHEMISTRY
- Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics
- (2021) Simone Schierle et al. JOURNAL OF MEDICINAL CHEMISTRY
- Quantitative Immunohistochemistry to Measure Regional Expression of Nurr1 in the Brain and the Effect of the Nurr1 Heterozygous Genotype
- (2021) Evangel Kummari et al. Frontiers in Neuroanatomy
- Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1
- (2021) Svetlana A. Kholodar et al. ACS Chemical Biology
- Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation
- (2021) Sabine Willems et al. JOURNAL OF MEDICINAL CHEMISTRY
- Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1
- (2021) Daniel Zaienne et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators
- (2021) Alisa Lang et al. JOURNAL OF MEDICINAL CHEMISTRY
- A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
- (2020) David E. Gordon et al. NATURE
- PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
- (2020) Sreekanth Rajan et al. Nature Chemical Biology
- Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation
- (2020) Karolien De Bosscher et al. Nature Reviews Endocrinology
- Nuclear receptor phosphorylation in xenobiotic signal transduction
- (2020) Masahiko Negishi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Design and Structural Optimization of Dual FXR/PPARδ Activators
- (2020) Simone Schierle et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications
- (2020) Marta Pajares et al. Cells
- The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugs
- (2020) Sabine Willems et al. Communications Chemistry
- Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression
- (2020) Peng-bo Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of phospholipase A2 by prostaglandin in vitro
- (2020) Christian Code et al. PROSTAGLANDINS & OTHER LIPID MEDIATORS
- PPARα ligand-binding domain structures with endogenous fatty acids and fibrates
- (2020) Shotaro Kamata et al. iScience
- Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1
- (2020) Paola Munoz-Tello et al. JOURNAL OF MEDICINAL CHEMISTRY
- UniProt: the universal protein knowledgebase in 2021
- (2020) et al. NUCLEIC ACIDS RESEARCH
- Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease
- (2019) Dominique Lesuisse et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Molecular tuning of farnesoid X receptor partial agonism
- (2019) Daniel Merk et al. Nature Communications
- NURR1 Impairment in Multiple Sclerosis
- (2019) Francesca Montarolo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- NURR1 deficiency is associated to ADHD-like phenotypes in mice
- (2019) Francesca Montarolo et al. Translational Psychiatry
- Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells
- (2019) Yangshun Tang et al. TOXICOLOGY IN VITRO
- Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review
- (2018) Domenico Plantone et al. CLINICAL DRUG INVESTIGATION
- Genetic disruption of the nuclear receptor Nur77 (Nr4a1) in rat reduces dopamine cell loss and l -Dopa-induced dyskinesia in experimental Parkinson's disease
- (2018) Claude Rouillard et al. EXPERIMENTAL NEUROLOGY
- Compensatory Expression of Nur77 and Nurr1 Regulates NF-κB–Dependent Inflammatory Signaling in Astrocytes
- (2018) Katriana A. Popichak et al. MOLECULAR PHARMACOLOGY
- The nuclear receptor superfamily: A structural perspective
- (2018) Emily R. Weikum et al. PROTEIN SCIENCE
- Nurr1 (NR4A2) regulates Alzheimer’s disease-related pathogenesis and cognitive function in the 5XFAD mouse model
- (2018) Minho Moon et al. AGING CELL
- Structural Insights into Ligand-Binding Pocket Formation in Nurr1 by Molecular Dynamics Simulations
- (2018) Björn Windshügel JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1
- (2018) Ian Mitchelle S. de Vera et al. STRUCTURE
- NR4A2 genetic variation and Parkinson's disease: Evidence from a systematic review and meta-analysis
- (2017) Hongmei Liu et al. NEUROSCIENCE LETTERS
- Nurr1:RXRα heterodimer activation as monotherapy for Parkinson’s disease
- (2017) Athanasios D. Spathis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
- (2017) Lena F. Burbulla et al. SCIENCE
- Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1
- (2016) Ian Mitchelle S. de Vera et al. ACS Chemical Biology
- Nurr1-Based Therapies for Parkinson's Disease
- (2016) Jie Dong et al. CNS Neuroscience & Therapeutics
- Docosahexaenoic acid: one molecule diverse functions
- (2016) Michio Hashimoto et al. CRITICAL REVIEWS IN BIOTECHNOLOGY
- Nuclear receptor expression atlas in BMDCs: Nr4a2 restricts immunogenicity of BMDCs and impedes EAE
- (2016) Ankita Saini et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- 4-amino-7-chloroquinoline derivatives for treating Parkinson’s disease: implications for drug discovery
- (2016) Chun-Hyung Kim et al. Expert Opinion on Drug Discovery
- Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor–Nuclear Receptor Related 1 Protein Dimer Activation
- (2016) Henrik Sundén et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nuclear receptor 4A (NR4A) family – orphans no more
- (2016) Stephen Safe et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Selective brain penetrable Nurr1 transactivator for treating Parkinson’s disease
- (2016) Jun Wang et al. Oncotarget
- A Critical Review of the Effects of Hydroxychloroquine and Chloroquine on the Eye
- (2015) Nathalie Costedoat-Chalumeau et al. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- Nurr1 reduction influences the onset of chronic EAE in mice
- (2015) Francesca Montarolo et al. INFLAMMATION RESEARCH
- Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin
- (2015) Joseph M McCoy et al. Journal of Inflammation-London
- Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate -Synuclein Disrupted Gene Expression
- (2015) N. Volakakis et al. JOURNAL OF NEUROSCIENCE
- Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment
- (2015) Xiaobo Wei et al. MOLECULAR NEUROBIOLOGY
- Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
- (2015) Li Li et al. Nature Chemical Biology
- Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease
- (2015) Chun-Hyung Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Advances in our structural understanding of orphan nuclear receptors
- (2015) Nerea Gallastegui et al. TRENDS IN BIOCHEMICAL SCIENCES
- A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C)
- (2015) Gaynor A. Smith et al. PLoS One
- Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation
- (2014) S.-H. Yi et al. DEVELOPMENT
- Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice, an animal model of Alzheimer's disease
- (2014) Minho Moon et al. JOURNAL OF NEUROCHEMISTRY
- Crtc1 Activates a Transcriptional Program Deregulated at Early Alzheimer's Disease-Related Stages
- (2014) A. Parra-Damas et al. JOURNAL OF NEUROSCIENCE
- Effects of Isoxazolo-Pyridinone 7e, a Potent Activator of the Nurr1 Signaling Pathway, on Experimental Autoimmune Encephalomyelitis in Mice
- (2014) Francesca Montarolo et al. PLoS One
- NR4A nuclear receptors in immunity and atherosclerosis
- (2013) Anouk A.J. Hamers et al. CURRENT OPINION IN LIPIDOLOGY
- Understanding nuclear receptor form and function using structural biology
- (2013) Fraydoon Rastinejad et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- An evolving understanding of nuclear receptor coregulator proteins
- (2013) Christopher J Millard et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- -Amyloid Disrupts Activity-Dependent Gene Transcription Required for Memory through the CREB Coactivator CRTC1
- (2013) J. Espana et al. JOURNAL OF NEUROSCIENCE
- Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons
- (2013) Xin Heng et al. Molecular Neurodegeneration
- Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway
- (2013) Wei-jia Wang et al. Nature Chemical Biology
- NURR1 in Parkinson disease—from pathogenesis to therapeutic potential
- (2013) Mickael Decressac et al. Nature Reviews Neurology
- Nuclear Receptor NR4A2 Orchestrates Th17 Cell-Mediated Autoimmune Inflammation via IL-21 Signalling
- (2013) Ben J. E. Raveney et al. PLoS One
- PIASγ Enhanced SUMO-2 Modification of Nurr1 Activation-Function-1 Domain Limits Nurr1 Transcriptional Synergy
- (2013) Cristian Arredondo et al. PLoS One
- Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons
- (2013) B. Kadkhodaei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cell signalling by reactive lipid species: new concepts and molecular mechanisms
- (2012) Ashlee Higdon et al. BIOCHEMICAL JOURNAL
- Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3′-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells
- (2012) Xi Li et al. BIOCHEMICAL PHARMACOLOGY
- Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine
- (2012) Soon Goo Lee et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
- (2012) Yan-yan Zhan et al. Nature Chemical Biology
- Human SOD2 Modification by Dopamine Quinones Affects Enzymatic Activity by Promoting Its Aggregation: Possible Implications for Parkinson’s Disease
- (2012) Elisa Belluzzi et al. PLoS One
- -Synuclein-Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons
- (2012) M. Decressac et al. Science Translational Medicine
- Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease
- (2010) Michael A. Pearen et al. MOLECULAR ENDOCRINOLOGY
- NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection
- (2010) N. Volakakis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- BLAST+: architecture and applications
- (2009) Christiam Camacho et al. BMC BIOINFORMATICS
- A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death
- (2009) Kaoru Saijo et al. CELL
- Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons
- (2009) F. M. J. Jacobs et al. DEVELOPMENT
- The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson’s disease
- (2009) Teresa G. Hastings JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons
- (2009) B. Kadkhodaei et al. JOURNAL OF NEUROSCIENCE
- Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons
- (2009) Eugene V. Mosharov et al. NEURON
- Corepressor interaction differentiates the permissive and non-permissive retinoid X receptor heterodimers
- (2008) Johanna Lammi et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth
- (2008) T. Inamoto et al. MOLECULAR CANCER THERAPEUTICS
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