An evolving understanding of nuclear receptor coregulator proteins

The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts

(2013) Richard D.W. Kelly et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

(2013) A. Mottis et al.   GENES & DEVELOPMENT

A P(E)RM(I)T for BMP Signaling

(2013) Xing Guo et al.   MOLECULAR CELL

Proteomic Analysis of Coregulators Bound to ERα on DNA and Nucleosomes Reveals Coregulator Dynamics

(2013) Charles E. Foulds et al.   MOLECULAR CELL

Multidomain integration in the structure of the HNF-4α nuclear receptor complex

(2013) Vikas Chandra et al.   NATURE

The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle

(2013) Nadia Arnaudo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nα-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain

(2013) Dongxue Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation

(2013) Manuela Delvecchio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA

(2013) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct functions for RIP140 in development, inflammation, and metabolism

(2013) Jaya Nautiyal et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Complex dynamics of transcription regulation

(2012) Diana A. Stavreva et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Histone acetyltransferases: Rising ancient counterparts to protein kinases

(2012) Hua Yuan et al.   BIOPOLYMERS

The Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 Recognition

(2012) Chao He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the N-terminal Domain of the Yeast General Corepressor Tup1p and Its Functional Implications

(2012) Hiroyoshi Matsumura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MBD2 and Multiple Domains of CHD4 Are Required for Transcriptional Repression by Mi-2/NuRD Complexes

(2012) J. Ramirez et al.   MOLECULAR AND CELLULAR BIOLOGY

LSD2/KDM1B and Its Cofactor NPAC/GLYR1 Endow a Structural and Molecular Model for Regulation of H3K4 Demethylation

(2012) Rui Fang et al.   MOLECULAR CELL

A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis

(2012) Sang Jun Han et al.   NATURE MEDICINE

Nuclear receptor coregulators: modulators of pathology and therapeutic targets

(2012) David M. Lonard et al.   Nature Reviews Endocrinology

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

Writers and readers: deconvoluting the harmonic complexity of the histone code

(2012) Michael S Cosgrove   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of the human PRMT5:MEP50 complex

(2012) S. Antonysamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of the Mediator Head Module with RNA Polymerase II

(2012) Gang Cai et al.   STRUCTURE

Non-coding RNAs: key regulators of mammalian transcription

(2012) Jennifer F. Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular architecture of human polycomb repressive complex 2

(2012) Claudio Ciferri et al.   eLife

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Alternative mRNA Splicing of Corepressors Generates Variants That Play Opposing Roles in Adipocyte Differentiation

(2011) Michael L. Goodson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OPERating ON Chromatin, a Colorful Language where Context Matters

(2011) Kathryn E. Gardner et al.   JOURNAL OF MOLECULAR BIOLOGY

Nuclear hormone receptor co-repressors: Structure and function

(2011) Peter J. Watson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Structure and mechanism of the chromatin remodelling factor ISW1a

(2011) Kazuhiro Yamada et al.   NATURE

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin

(2011) Sebastian Eustermann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery

(2011) Jasmeen Oberoi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis of Silencing: Sir3 BAH Domain in Complex with a Nucleosome at 3.0 A Resolution

(2011) K.-J. Armache et al.   SCIENCE

Nuclear Receptor Coactivators: Structural and Functional Biochemistry

(2010) Yaroslava A. Bulynko et al.   BIOCHEMISTRY

Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation

(2010) Natalia Varlakhanova et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Chromodomains of the Chd1 Chromatin Remodeler Regulate DNA Access to the ATPase Motor

(2010) Glenn Hauk et al.   MOLECULAR CELL

Structure of RCC1 chromatin factor bound to the nucleosome core particle

(2010) Ravindra D. Makde et al.   NATURE

Structure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor–co-repressor interaction

(2010) Caroline A Phelan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Biology of Chromatin Remodeling Complexes

(2009) Cedric R. Clapier et al.   Annual Review of Biochemistry

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes

(2009) Lisa R. Racki et al.   NATURE

Dynamics of nucleosome remodelling by individual ACF complexes

(2009) Timothy R. Blosser et al.   NATURE

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

Structural basis of histone H4 recognition by p55

(2008) J.-J. Song et al.   GENES & DEVELOPMENT

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

(2008) P. A.C. Cloos et al.   GENES & DEVELOPMENT

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

(2008) Xin Liu et al.   NATURE

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE

Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300

(2008) Lei Zeng et al.   STRUCTURE

Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46

(2008) Natalia V. Murzina et al.   STRUCTURE

Cancer Epigenetics: Modifications, Screening, and Therapy

(2007) Gal-Yam Einav Nili et al.   Annual Review of Medicine