DEAD box 1 (DDX1) protein binds to and protects cytoplasmic stress response mRNAs in cells exposed to oxidative stress

A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing

(2021) Teruhiko Suzuki et al.   NUCLEIC ACIDS RESEARCH

Modulation of RNA Condensation by the DEAD-Box Protein eIF4A

(2020) Devin Tauber et al.   CELL

A missense mutation in the CSTF2 gene that impairs the function of the RNA recognition motif and causes defects in 3′ end processing is associated with intellectual disability in humans

(2020) Petar N Grozdanov et al.   NUCLEIC ACIDS RESEARCH

Molecular mechanisms of stress granule assembly and disassembly

(2020) Sarah Hofmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules

(2020) Daniel Mateju et al.   CELL

Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response

(2019) Johannes H. Wilbertz et al.   MOLECULAR CELL

Elucidation of the phenotypic spectrum and genetic landscape in primary and secondary microcephaly

(2019) Paranchai Boonsawat et al.   GENETICS IN MEDICINE

Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout

(2019) Matthew R. Hildebrandt et al.   DEVELOPMENTAL BIOLOGY

DEAD-box ATPases are global regulators of phase-separated organelles

(2019) Maria Hondele et al.   NATURE

Stress granules and neurodegeneration

(2019) Benjamin Wolozin et al.   NATURE REVIEWS NEUROSCIENCE

FAM98A is localized to stress granules and associates with multiple stress granule-localized proteins

(2018) Kanako Ozeki et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination

(2018) Claudia Ribeiro de Almeida et al.   MOLECULAR CELL

Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation

(2018) Dinghai Zheng et al.   Nature Communications

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Friend or foe — post-translational modifications as regulators of phase separation and RNP granule dynamics

(2018) Mario Hofweber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Dynamics of mRNA Turnover Revealed by Single-Molecule Imaging in Single Cells

(2017) Ivana Horvathova et al.   MOLECULAR CELL

The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules

(2017) Anthony Khong et al.   MOLECULAR CELL

A DEAD-box protein acts through RNA to promote HIV-1 Rev-RRE assembly

(2017) Rajan Lamichhane et al.   NUCLEIC ACIDS RESEARCH

Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells

(2017) Manuel D. Díaz-Muñoz et al.   Nature Communications

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

DEAD Box 1 Facilitates Removal of RNA and Homologous Recombination at DNA Double-Strand Breaks

(2016) Lei Li et al.   MOLECULAR AND CELLULAR BIOLOGY

The differential expression of alternatively polyadenylated transcripts is a common stress-induced response mechanism that modulates mammalian mRNA expression in a quantitative and qualitative fashion

(2016) Ina Hollerer et al.   RNA

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

(2016) Yasmine A. Valentin-Vega et al.   Scientific Reports

Distinct stages in stress granule assembly and disassembly

(2016) Joshua R Wheeler et al.   eLife

Stress granules, P-bodies and cancer

(2015) Paul Anderson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Loss of the Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis

(2015) Devon R. Germain et al.   DEVELOPMENTAL BIOLOGY

Synergistic effects of ATP and RNA binding to human DEAD-box protein DDX1

(2015) Julian N. Kellner et al.   NUCLEIC ACIDS RESEARCH

CLIPSeqTools—a novel bioinformatics CLIP-seq analysis suite

(2015) Manolis Maragkakis et al.   RNA

Ddx1 knockout results in transgenerational wild-type lethality in mice

(2015) Matthew R. Hildebrandt et al.   Scientific Reports

Structure of the SPRY domain of the human RNA helicase DDX1, a putative interaction platform within a DEAD-box protein

(2015) Julian N. Kellner et al.   Acta Crystallographica Section F-Structural Biology Communications

SDHAF4 Promotes Mitochondrial Succinate Dehydrogenase Activity and Prevents Neurodegeneration

(2014) Jonathan G. Van Vranken et al.   Cell Metabolism

Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors

(2014) Johannes Popow et al.   NATURE

Stress granules are dispensable for mRNA stabilization during cellular stress

(2014) Nadine Bley et al.   NUCLEIC ACIDS RESEARCH

The RNA-Binding Protein DDX1 Promotes Primary MicroRNA Maturation and Inhibits Ovarian Tumor Progression

(2014) Cecil Han et al.   Cell Reports

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

The eIF2α kinases: their structures and functions

(2013) Neysan Donnelly et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Stress granules and cell signaling: more than just a passing phase?

(2013) Nancy Kedersha et al.   TRENDS IN BIOCHEMICAL SCIENCES

Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP

(2012) Anaïs Aulas et al.   Molecular Neurodegeneration

P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation

(2012) C. J. Decker et al.   Cold Spring Harbor Perspectives in Biology

The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules

(2011) S. A. Kunde et al.   HUMAN MOLECULAR GENETICS

DDX1 Is an RNA-Dependent ATPase Involved in HIV-1 Rev Function and Virus Replication

(2011) Stephen P. Edgcomb et al.   JOURNAL OF MOLECULAR BIOLOGY

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

(2011) Jodi Meyerowitz et al.   Molecular Neurodegeneration

From unwinding to clamping — the DEAD box RNA helicase family

(2011) Patrick Linder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DEAD box 1: a novel and independent prognostic marker for early recurrence in breast cancer

(2010) Devon R. Germain et al.   BREAST CANCER RESEARCH AND TREATMENT

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Combinations of DEAD box proteins distinguish distinct types of RNA: Protein complexes in neurons

(2009) Linda C. Miller et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

P bodies promote stress granule assembly inSaccharomyces cerevisiae

(2008) J. Ross Buchan et al.   JOURNAL OF CELL BIOLOGY

MBNL1 associates with YB-1 in cytoplasmic stress granules

(2008) Hayato Onishi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Role for DEAD Box 1 at DNA Double-Strand Breaks

(2008) L. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

The DEAD-Box RNA Helicase DDX3 Associates with Export Messenger Ribonucleoproteins as well asTip-associated Protein and Participates in Translational Control

(2008) Ming-Chih Lai et al.   MOLECULAR BIOLOGY OF THE CELL

Stress granules: the Tao of RNA triage

(2008) Paul Anderson et al.   TRENDS IN BIOCHEMICAL SCIENCES