Sex hormone fluctuation and increased female risk for depression and anxiety disorders: From clinical evidence to molecular mechanisms

A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior

(2022) Joseph R. Knoedler et al.   CELL

Gene regulation by gonadal hormone receptors underlies brain sex differences

(2022) B. Gegenhuber et al.   NATURE

Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains

(2022) Kiran Girdhar et al.   NATURE NEUROSCIENCE

Sex-specific multi-level 3D genome dynamics in the mouse brain

(2022) Devin Rocks et al.   Nature Communications

BDNF signaling in depression and antidepressant action

(2021) Eero Castrén et al.   BIOLOGICAL PSYCHIATRY

The dynamics of chromatin architecture in brain development and function

(2021) Izabela Harabula et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders

(2021) Benxia Hu et al.   Nature Communications

Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition

(2021) Lisa Mosconi et al.   Scientific Reports

Premenstrual Exacerbations of Mood Disorders: Findings and Knowledge Gaps

(2021) Christine Kuehner et al.   Current Psychiatry Reports

Mapping global prevalence of depression among postpartum women

(2021) Ziyi Wang et al.   Translational Psychiatry

Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer

(2020) Joanna Achinger-Kawecka et al.   Nature Communications

Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression

(2020) Jonathan A. Beagan et al.   NATURE NEUROSCIENCE

Ovariectomy-induced depressive-like behavior and brain glucose metabolism changes in female rats are not affected by chronic mild stress

(2020) M.A. Khayum et al.   PSYCHONEUROENDOCRINOLOGY

Neuroimaging the menstrual cycle: A multimodal systematic review

(2020) Manon Dubol et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble

(2020) Asaf Marco et al.   NATURE NEUROSCIENCE

Ketamine and Serotonergic Psychedelics: Common Mechanisms Underlying the Effects of Rapid-Acting Antidepressants

(2020) Bashkim Kadriu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Structural plasticity of the hippocampus in response to estrogens in female rodents

(2019) Paul A. S. Sheppard et al.   Molecular Brain

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

Sex and Estrous Cycle Effects on Anxiety- and Depression-Related Phenotypes in a Two-Hit Developmental Stress Model

(2019) Ivana Jaric et al.   Frontiers in Molecular Neuroscience

Chromatin organization in the female mouse brain fluctuates across the oestrous cycle

(2019) Ivana Jaric et al.   Nature Communications

(R)-Ketamine Rapidly Ameliorates the Decreased Spine Density in the Medial Prefrontal Cortex and Hippocampus of Susceptible Mice After Chronic Social Defeat Stress

(2019) Jiancheng Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus

(2019) Jordi Fernandez-Albert et al.   NATURE NEUROSCIENCE

Estradiol Alters Hippocampal Gene Expression during the Estrous Cycle

(2019) Javed Iqbal et al.   ENDOCRINE RESEARCH

Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine

(2019) Satoshi Deyama et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Meta-Analysis of 89 Structural MRI Studies in Posttraumatic Stress Disorder and Comparison With Major Depressive Disorder

(2018) Konstantinos Bromis et al.   AMERICAN JOURNAL OF PSYCHIATRY

Signaling by Steroid Hormones in the 3D Nuclear Space

(2018) François Le Dily et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chromatin Regulation of Neuronal Maturation and Plasticity

(2018) David A. Gallegos et al.   TRENDS IN NEUROSCIENCES

Psychedelics Promote Structural and Functional Neural Plasticity

(2018) Calvin Ly et al.   Cell Reports

Epidemiology of Adult DSM-5 Major Depressive Disorder and Its Specifiers in the United States

(2018) Deborah S. Hasin et al.   JAMA Psychiatry

Economic and Health Predictors of National Postpartum Depression Prevalence: A Systematic Review, Meta-analysis, and Meta-Regression of 291 Studies from 56 Countries

(2018) Jennifer Hahn-Holbrook et al.   Frontiers in Psychiatry

Deletion of Dlk1 increases the vulnerability to developing anxiety-like behaviors and ethanol consumption in mice

(2018) María S. García-Gutiérrez et al.   BIOCHEMICAL PHARMACOLOGY

Hormone-control regions mediate steroid receptor–dependent genome organization

(2018) François Le Dily et al.   GENOME RESEARCH

Organizational principles of 3D genome architecture

(2018) M. Jordan Rowley et al.   NATURE REVIEWS GENETICS

Depression During and After the Perimenopause

(2018) Joyce T. Bromberger et al.   OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA

The stability of the transcriptome during the estrous cycle in four regions of the mouse brain

(2017) Lisa M. DiCarlo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection

(2017) Thomas Vierbuchen et al.   MOLECULAR CELL

Brain-derived neurotrophic factor Val66Met genotype and ovarian steroids interactively modulate working memory-related hippocampal function in women: a multimodal neuroimaging study

(2017) S-M Wei et al.   MOLECULAR PSYCHIATRY

Neuronal activity modifies the chromatin accessibility landscape in the adult brain

(2017) Yijing Su et al.   NATURE NEUROSCIENCE

Why estrogens matter for behavior and brain health

(2017) Liisa A.M. Galea et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Impact of Proestrus on Gene Expression in the Medial Preoptic Area of Mice

(2017) Csaba Vastagh et al.   Frontiers in Cellular Neuroscience

A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice

(2017) Jordan Marrocco et al.   Nature Communications

Anxiety disorders

(2017) Michelle G. Craske et al.   Nature Reviews Disease Primers

Inducible chromatin priming is associated with the establishment of immunological memory in T cells

(2016) S. L. Bevington et al.   EMBO JOURNAL

Sex differences in hippocampal function

(2016) Wendy A. Koss et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Pregnancy leads to long-lasting changes in human brain structure

(2016) Elseline Hoekzema et al.   NATURE NEUROSCIENCE

Organization and function of the 3D genome

(2016) Boyan Bonev et al.   NATURE REVIEWS GENETICS

Neuronal CTCF Is Necessary for Basal and Experience-Dependent Gene Regulation, Memory Formation, and Genomic Structure of BDNF and Arc

(2016) Dev Sharan Sams et al.   Cell Reports

Major depressive disorder

(2016) Christian Otte et al.   Nature Reviews Disease Primers

In-vivo Dynamics of the Human Hippocampus across the Menstrual Cycle

(2016) Claudia Barth et al.   Scientific Reports

Ovarian Hormone Fluctuation, Neurosteroids, and HPA Axis Dysregulation in Perimenopausal Depression: A Novel Heuristic Model

(2015) Jennifer L. Gordon et al.   AMERICAN JOURNAL OF PSYCHIATRY

Role of Serotonin Transporter Changes in Depressive Responses to Sex-Steroid Hormone Manipulation: A Positron Emission Tomography Study

(2015) Vibe Gedsoe Frokjaer et al.   BIOLOGICAL PSYCHIATRY

Molecular signature of rapid estrogen regulation of synaptic connectivity and cognition

(2015) Katherine Sellers et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Sex differences in anxiety disorders: Interactions between fear, stress, and gonadal hormones

(2015) Lisa Y. Maeng et al.   HORMONES AND BEHAVIOR

Hippocampal volume and functional connectivity changes during the female menstrual cycle

(2015) Nina Lisofsky et al.   NEUROIMAGE

Forced swim test: What about females?

(2015) Nikolaos Kokras et al.   NEUROPHARMACOLOGY

Spine synapse remodeling in the pathophysiology and treatment of depression

(2015) Catharine H. Duman et al.   NEUROSCIENCE LETTERS

Estradiol levels modulate brain activity and negative responses to psychosocial stress across the menstrual cycle

(2015) Kimberly Albert et al.   PSYCHONEUROENDOCRINOLOGY

Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods

(2015) Claudia Barth et al.   Frontiers in Neuroscience

Progressive alterations of hippocampal CA3-CA1 synapses in an animal model of depression

(2014) Hui Qiao et al.   BEHAVIOURAL BRAIN RESEARCH

Sex differences in anxiety and depression clinical perspectives

(2014) Margaret Altemus et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Hippocampal synaptic plasticity, spatial memory and anxiety

(2014) David M. Bannerman et al.   NATURE REVIEWS NEUROSCIENCE

Menstrual-cycle dependent fluctuations in ovarian hormones affect emotional memory

(2014) Janine Bayer et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Hippocampal Atrophy in Major Depression: a Function of Childhood Maltreatment Rather than Diagnosis?

(2014) Nils Opel et al.   NEUROPSYCHOPHARMACOLOGY

Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling

(2013) Luca Magnani et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus

(2013) Mazen A. Kheirbek et al.   NEURON

Sex differences in the antidepressant-like effects of ketamine

(2013) Nicole Carrier et al.   NEUROPHARMACOLOGY

Sex differences in anxiety and emotional behavior

(2013) Nina C. Donner et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure

(2013) M. Kundakovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen synthesis and signaling pathways during aging: from periphery to brain

(2013) Jie Cui et al.   TRENDS IN MOLECULAR MEDICINE

Variant Brain-Derived Neurotrophic Factor (Valine66Methionine) Polymorphism Contributes to Developmental and Estrous Stage-Specific Expression of Anxiety-Like Behavior in Female Mice

(2012) Kevin G. Bath et al.   BIOLOGICAL PSYCHIATRY

RAPID RESPONSE TO FLUOXETINE IN WOMEN WITH PREMENSTRUAL DYSPHORIC DISORDER

(2012) Emma M. Steinberg et al.   DEPRESSION AND ANXIETY

State-dependent changes in hippocampal grey matter in depression

(2012) D Arnone et al.   MOLECULAR PSYCHIATRY

Estradiol Modulates Medial Prefrontal Cortex and Amygdala Activity During Fear Extinction in Women and Female Rats

(2011) Mohamed A. Zeidan et al.   BIOLOGICAL PSYCHIATRY

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

(2011) Nanxin Li et al.   BIOLOGICAL PSYCHIATRY

Rapid Estrogen Signaling in the Brain: Implications for the Fine-Tuning of Neuronal Circuitry

(2011) D. P. Srivastava et al.   JOURNAL OF NEUROSCIENCE

Long-term ovariectomy modulates the antidepressant-like action of estrogens, but not of antidepressants

(2011) Erika Estrada-Camarena et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis

(2011) Sacri R. Ferrón et al.   NATURE

Determinants and dynamics of genome accessibility

(2011) Oliver Bell et al.   NATURE REVIEWS GENETICS

Changes in Brain Size during the Menstrual Cycle

(2011) Georg Hagemann et al.   PLoS One

Exercise training increases size of hippocampus and improves memory

(2011) K. I. Erickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of menstrual cycle phase on corticolimbic brain activation by visual food cues

(2010) Tamar C. Frank et al.   BRAIN RESEARCH

Gender differences in the developmental course of depression

(2010) Cecilia A. Essau et al.   JOURNAL OF AFFECTIVE DISORDERS

The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?

(2010) G MacQueen et al.   MOLECULAR PSYCHIATRY

Menstrual cycle modulation of medial temporal activity evoked by negative emotion

(2010) Joseph M. Andreano et al.   NEUROIMAGE

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

(2010) Michael S. Fanselow et al.   NEURON

BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function

(2010) J. L. Spencer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mindfulness practice leads to increases in regional brain gray matter density

(2010) Britta K. Hölzel et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

A Cross-Sectional Evaluation of Perimenopausal Depression

(2009) Emma M. Steinberg et al.   JOURNAL OF CLINICAL PSYCHIATRY

Population genetic study of the brain-derived neurotrophic factor (BDNF) gene

(2009) T L Petryshen et al.   MOLECULAR PSYCHIATRY

Perspective: Sex Matters: Gonadal Steroids and the Brain

(2009) Elizabeth A Young et al.   NEUROPSYCHOPHARMACOLOGY

Estrous cycle phase and gonadal hormones influence conditioned fear extinction

(2009) M.R. Milad et al.   NEUROSCIENCE

Role of estradiol withdrawal in ‘anhedonic’ sucrose consumption: A model of postpartum depression

(2009) Amanda D. Green et al.   PHYSIOLOGY & BEHAVIOR

Genomic–anatomic evidence for distinct functional domains in hippocampal field CA1

(2009) Hong-Wei Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression

(2008) Tibor Hajszan et al.   BIOLOGICAL PSYCHIATRY

Sex differences in depression symptoms in treatment-seeking adults: confirmatory analyses from the Sequenced Treatment Alternatives to Relieve Depression study

(2008) Sheila M. Marcus et al.   COMPREHENSIVE PSYCHIATRY

Hippocampal structural changes across the menstrual cycle

(2008) Xenia Protopopescu et al.   HIPPOCAMPUS

Premenstrual syndrome

(2008) Kimberly Ann Yonkers et al.   LANCET

BDNFgene: functional Val66Met polymorphism in mood disorders and schizophrenia

(2008) Janusz K Rybakowski   PHARMACOGENOMICS

Non-genomic actions of estrogens and their interaction with genomic actions in the brain

(2007) Nandini Vasudevan et al.   FRONTIERS IN NEUROENDOCRINOLOGY

From menarche to menopause: Exploring the underlying biology of depression in women experiencing hormonal changes

(2007) Darlene Deecher et al.   PSYCHONEUROENDOCRINOLOGY