期刊
PHYSIOLOGY & BEHAVIOR
卷 97, 期 2, 页码 259-265出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2009.02.020
关键词
Anhedonia; Postpartum depression; Hormone simulated pregnancy; Sucrose consumption; Sucrose preference; Imipramine; Estradiol withdrawal; Progesterone
资金
- NARSAD
Previously, a hormone-simulated pregnancy (HSP), and the subsequent 'postpartum' withdrawal in estradiol has been shown to precipitate depressive-like behaviours in the forced swim test in female rats. In this study, we used the HSP and 'postpartum' withdrawal to investigate the impact on sucrose consumption, a model of anhedonia. Rats were assigned to postpartum, postpartum + EB (estradiol benzoate), postpartum + IN (imipramine; a tricyclic antidepressant), postpartum + DPN (diarylpropionitrile; an ER beta agonist), or ovariectomized (OVX) controls and OVX + IMI treatments. All postpartum groups received daily hormone injections (estradiol and progesterone) over 23 days to simulate pregnancy, while IMI groups also received daily injections of imipramine. After Day 23, postpartum rats were withdrawn from the hormone regimen (mimicking the postpartum decrease in gonadal hormones), and then received daily injections of compounds indicated (DPN, EB. IMI). Rats were tested for consumption of, and preference for, sucrose weekly at baseline, during 'pregnancy' and on 'Postpartum' Days 2-3. During the 'postpartum' period rats in the postpartum group had lower sucrose consumption and preference compared to during late-'pregnancy', but no decrease in 'postpartum' consumption or preference was seen in any other groups except postpartum + IMI and a decrease in sucrose preference only in the Postpartum + EB group from mid-'pregnancy' to 'postpartum'. The OVX + IMI group had decreased sucrose consumption relative to OVX controls, suggesting a negative effect of imipramine on sucrose consumption. Together, these results suggest an important, though complex, role for gonadal hormones in the behavioral changes accompanying this model of depression. (c) 2009 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据