AATF /Che‐1 localizes to paraspeckles and suppresses R‐loops accumulation and interferon activation in Multiple Myeloma

Recognition of RNA by the S9.6 antibody creates pervasive artifacts when imaging RNA:DNA hybrids

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Transcription/Replication Conflicts in Tumorigenesis and Their Potential Role as Novel Therapeutic Targets in Multiple Myeloma

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(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Che-1/AATF binds to RNA polymerase I machinery and sustains ribosomal RNA gene transcription

(2020) Cristina Sorino et al.   NUCLEIC ACIDS RESEARCH

Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma

(2020) Hector H. Huang et al.   Nature Communications

Genome instability in multiple myeloma

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A large-scale binding and functional map of human RNA-binding proteins

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Nucleolar RNA polymerase II drives ribosome biogenesis

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The integrated stress response induces R-loops and hinders replication fork progression

(2020) Josephine Ann Mun Yee Choo et al.   Cell Death & Disease

SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

(2019) Eleonora Petti et al.   Nature Communications

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

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DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

A protein-RNA interaction atlas of the ribosome biogenesis factor AATF

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Long non-coding RNA NEAT1 targeting impairs the DNA repair machinery and triggers anti-tumor activity in multiple myeloma

(2019) Elisa Taiana et al.   LEUKEMIA

R Loops: From Physiological to Pathological Roles

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Che‐1 is targeted by c‐Myc to sustain proliferation in pre‐B‐cell acute lymphoblastic leukemia

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Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

(2018) Tomohiro Yamazaki et al.   MOLECULAR CELL

AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer

(2018) Daniela Welcker et al.   ONCOGENE

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

(2018) Alisa F. Zyryanova et al.   SCIENCE

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

(2018) Jordan C. Tsai et al.   SCIENCE

Paraspeckles: Where Long Noncoding RNA Meets Phase Separation

(2018) Archa H. Fox et al.   TRENDS IN BIOCHEMICAL SCIENCES

Proinflammatory Signals as Fuel for the Fire of Hematopoietic Stem Cell Emergence

(2018) Raquel Espin-Palazon et al.   TRENDS IN CELL BIOLOGY

Perturbation-response genes reveal signaling footprints in cancer gene expression

(2018) Michael Schubert et al.   Nature Communications

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage

(2018) Agnese Cristini et al.   Cell Reports

R-loop generation during transcription: Formation, processing and cellular outcomes

(2018) Boris P. Belotserkovskii et al.   DNA REPAIR

Long non-coding RNA NEAT1 shows high expression unrelated to molecular features and clinical outcome in multiple myeloma

(2018) Elisa Taiana et al.   HAEMATOLOGICA

Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress

(2018) Xiaofeng Liu et al.   NUCLEIC ACIDS RESEARCH

The PI3K/AKT axis modulates AATF activity in Wilms’ tumor cells

(2018) Peng Jing et al.   FEBS Open Bio

A Novel Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of NAFLD and HCC

(2018) Divya P. Kumar et al.   HEPATOLOGY

DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing

(2018) Prasun Chakraborty et al.   Nature Communications

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(2017) Harold Pimentel et al.   NATURE METHODS

Multiple myeloma

(2017) Shaji K. Kumar et al.   Nature Reviews Disease Primers

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(2016) Philip Ewels et al.   BIOINFORMATICS

Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals

(2016) Lionel A. Sanz et al.   MOLECULAR CELL

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(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Genomic complexity of multiple myeloma and its clinical implications

(2016) Salomon Manier et al.   Nature Reviews Clinical Oncology

Human AATF/Che-1 forms a nucleolar protein complex with NGDN and NOL10 required for 40S ribosomal subunit synthesis

(2016) Lukas Bammert et al.   NUCLEIC ACIDS RESEARCH

Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy

(2015) A. Desantis et al.   EMBO JOURNAL

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma

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Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells

(2015) Yu J. Shen et al.   Cell Reports

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome

(2015) Yoong Wearn Lim et al.   eLife

Discovering Che-1/AATF: a new attractive target for cancer therapy

(2015) Simona Iezzi et al.   Frontiers in Genetics

Interferon Gamma Signaling Positively Regulates Hematopoietic Stem Cell Emergence

(2014) Suphansa Sawamiphak et al.   DEVELOPMENTAL CELL

The Long Noncoding RNAs NEAT1 and MALAT1 Bind Active Chromatin Sites

(2014) Jason A. West et al.   MOLECULAR CELL

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Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

(2014) Niccolo Bolli et al.   Nature Communications

Out of Balance: R-loops in Human Disease

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NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies

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Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Nucleolar AATF regulates c-Jun–mediated apoptosis

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R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters

(2012) Paul A. Ginno et al.   MOLECULAR CELL

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(2012) Ben Langmead et al.   NATURE METHODS

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Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation

(2010) Tiziana Bruno et al.   CANCER CELL

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

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A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: An integrated genomics approach reveals a wide gene dosage effect

(2009) Luca Agnelli et al.   GENES CHROMOSOMES & CANCER

An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles

(2009) Christine M. Clemson et al.   MOLECULAR CELL

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