The integrated stress response induces R-loops and hinders replication fork progression

From R-Loops to G-Quadruplexes: Emerging New Threats for the Replication Fork

(2020) Antonio Maffia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mdm4 supports DNA replication in a p53-independent fashion

(2020) Kai Wohlberedt et al.   ONCOGENE

Interim tissue changes following connective tissue grafting and two‐stage implant placement. A randomized clinical trial

(2019) Dimitrios Papapetros et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

R Loops: From Physiological to Pathological Roles

(2019) Tatiana García-Muse et al.   CELL

Distinct mechanistic responses to replication fork stalling induced by either nucleotide or protein deprivation

(2018) Sofia Henriksson et al.   CELL CYCLE

Integrating the DNA damage and protein stress responses during cancer development and treatment

(2018) Vassilis G Gorgoulis et al.   JOURNAL OF PATHOLOGY

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

(2018) Alisa F. Zyryanova et al.   SCIENCE

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

(2018) Jordan C. Tsai et al.   SCIENCE

Chromatin conformation regulates the coordination between DNA replication and transcription

(2018) Ricardo Almeida et al.   Nature Communications

Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication

(2018) Ina Klusmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the unfolded protein response in cancer

(2017) Rani Ojha et al.   PHARMACOLOGICAL RESEARCH

Overview of CDK9 as a target in cancer research

(2016) Fatima Morales et al.   CELL CYCLE

Mobility of pharmaceutical compounds in the terrestrial environment: Adsorption kinetics of the macrocyclic lactone eprinomectin in soils

(2016) Litskas D. Vassilis et al.   CHEMOSPHERE

Drugging the addict: non‐oncogene addiction as a target for cancer therapy

(2016) Remco Nagel et al.   EMBO REPORTS

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1

(2016) E Cabrera et al.   ONCOGENE

A unique hypofractionated radiotherapy schedule with 51.3 Gy in 18 fractions three times per week for early breast cancer: outcomes including local control, acute and late skin toxicity

(2016) Kouloulias Vassilis et al.   Breast Cancer

p53 Activity Results in DNA Replication Fork Processivity

(2016) Ina Klusmann et al.   Cell Reports

Integrated stress response of vertebrates is regulated by four eIF2α kinases

(2016) Shusuke Taniuchi et al.   Scientific Reports

Exploiting replicative stress to treat cancer

(2015) Matthias Dobbelstein et al.   NATURE REVIEWS DRUG DISCOVERY

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

(2015) I. Das et al.   SCIENCE

Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma

(2015) L R Palam et al.   Cell Death & Disease

The MAPK-activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells

(2014) Frederik Köpper et al.   CELL CYCLE

A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression

(2014) K. Skourti-Stathaki et al.   GENES & DEVELOPMENT

Targeting tumour-supportive cellular machineries in anticancer drug development

(2014) Matthias Dobbelstein et al.   NATURE REVIEWS DRUG DISCOVERY

Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor

(2013) T K Albert et al.   BRITISH JOURNAL OF PHARMACOLOGY

A patient with partial trisomy 21 and 7q deletion expresses mild Down syndrome phenotype

(2013) I. Papoulidis et al.   GENE

New histone supply regulates replication fork speed and PCNA unloading

(2013) Jakob Mejlvang et al.   JOURNAL OF CELL BIOLOGY

Replication Dynamics: Biases and Robustness of DNA Fiber Analysis

(2013) Hervé Técher et al.   JOURNAL OF MOLECULAR BIOLOGY

R Loops Are Linked to Histone H3 S10 Phosphorylation and Chromatin Condensation

(2013) Maikel Castellano-Pozo et al.   MOLECULAR CELL

Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

(2013) F. Kopper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

(2012) Dong Hoon Suh et al.   Annals of the New York Academy of Sciences

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Chromatin replication and epigenome maintenance

(2012) Constance Alabert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Snapshots: Chromatin control of viral infection

(2012) David M. Knipe et al.   VIROLOGY

R-loop-mediated genomic instability is caused by impairment of replication fork progression

(2011) W. Gan et al.   GENES & DEVELOPMENT

Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB

(2010) Sonja Baumli et al.   CHEMISTRY & BIOLOGY

Replication Stress Interferes with Histone Recycling and Predeposition Marking of New Histones

(2010) Zuzana Jasencakova et al.   MOLECULAR CELL

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Chromatin organization and virus gene expression

(2008) Paul M. Lieberman   JOURNAL OF CELLULAR PHYSIOLOGY

Double-Stranded RNA-Dependent Protein Kinase-Dependent Apoptosis Induction by a Novel Small Compound

(2008) W. Hu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS