Methylglyoxal and glyoxalase 1—a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes

Advanced Glycation End Products Predict Loss of Renal Function and High-Risk Chronic Kidney Disease in Type 2 Diabetes

(2022) Juraj Koska et al.   DIABETES CARE

Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes

(2022) Naila Rabbani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Plasma advanced glycation end products and the subsequent risk of microvascular complications in type 1 diabetes in the DCCT/EDIC

(2022) Vincent M Monnier et al.   BMJ Open Diabetes Research & Care

Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors

(2022) Naila Rabbani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dicarbonyl stress, protein glycation and the unfolded protein response

(2021) Naila Rabbani et al.   GLYCOCONJUGATE JOURNAL

Protein glycation – biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine

(2021) Naila Rabbani et al.   Redox Biology

Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal

(2019) Zehra Irshad et al.   Scientific Reports

Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications and other age-related diseases

(2019) Casper Schalkwijk et al.   PHYSIOLOGICAL REVIEWS

Glyoxalase 1 Modulation in Obesity and Diabetes

(2018) Naila Rabbani et al.   ANTIOXIDANTS & REDOX SIGNALING

Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments

(2016) N. Rabbani et al.   CLINICAL SCIENCE

Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes

(2016) Pierre-Jean Saulnier et al.   DIABETES

Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation

(2016) Mingzhan Xue et al.   DIABETES

Glyoxalase 1-knockdown in human aortic endothelial cells – effect on the proteome and endothelial function estimates

(2016) Bernd Stratmann et al.   Scientific Reports

Post–Glucose Load Plasma α-Dicarbonyl Concentrations Are Increased in Individuals With Impaired Glucose Metabolism and Type 2 Diabetes: The CODAM Study

(2015) Dionne E. Maessen et al.   DIABETES CARE

Plasma Advanced Glycation End Products Are Associated With Incident Cardiovascular Events in Individuals With Type 2 Diabetes: A Case-Cohort Study With a Median Follow-up of 10 Years (EPIC-NL)

(2014) Nordin M.J. Hanssen et al.   DIABETES

Dicarbonyl Stress in the Absence of Hyperglycemia Increases Endothelial Inflammation and Atherogenesis Similar to That Observed in Diabetes

(2014) Chris Tikellis et al.   DIABETES

Arginine-directed glycation and decreased HDL plasma concentration and functionality

(2014) L Godfrey et al.   Nutrition & Diabetes

Small- and Large-Fiber Neuropathy After 40 Years of Type 1 Diabetes: Associations with glycemic control and advanced protein glycation: the Oslo Study

(2013) K. A. Sveen et al.   DIABETES CARE

Early Progression of Diabetic Nephropathy Correlates With Methylglyoxal-Derived Advanced Glycation End Products

(2013) P. J. Beisswenger et al.   DIABETES CARE

Structural Basis of the Unfolded Protein Response

(2012) Alexei Korennykh et al.   Annual Review of Cell and Developmental Biology

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

Serum Levels of Advanced Glycation Endproducts and Other Markers of Protein Damage in Early Diabetic Nephropathy in Type 1 Diabetes

(2012) Bruce A. Perkins et al.   PLoS One

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation

(2011) Mingzhan Xue et al.   BIOCHEMICAL JOURNAL

Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology

(2011) A. K. Berner et al.   DIABETOLOGIA

Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes

(2010) N. Karachalias et al.   DIABETOLOGIA

Advanced Glycation End Products in Extracellular Matrix Proteins Contribute to the Failure of Sensory Nerve Regeneration in Diabetes

(2009) Beatriz Duran-Jimenez et al.   DIABETES

Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone

(2008) Dag S. Fosmark et al.   ACTA OPHTHALMOLOGICA