NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice

Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease

(2022) Andreea L. Turcu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The role of Bcl-2 proteins in modulating neuronal Ca2+ signaling in health and in Alzheimer's disease

(2021) Manon Callens et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

FDA approves controversial Alzheimer’s drug despite uncertainty over effectiveness

(2021) Elisabeth Mahase   BMJ-British Medical Journal

Synaptic tau: A pathological or physiological phenomenon?

(2021) Miranda Robbins et al.   Acta Neuropathologica Communications

Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease

(2020) Divna Lazic et al.   NEUROBIOLOGY OF DISEASE

Glycogen synthase kinase-3 signaling in Alzheimer's disease

(2020) Elisabetta Lauretti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice

(2020) Júlia Companys-Alemany et al.   Pharmaceutics

Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling

(2020) Hongmei Shen et al.   Nature Communications

The Role of NMDA Receptors in Alzheimer’s Disease

(2019) Jinping Liu et al.   Frontiers in Neuroscience

Effects of the drug combination memantine and melatonin on impaired memory and brain neuronal deficits in an amyloid‐predominant mouse model of Alzheimer's disease

(2019) Monika Jürgenson et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Pharmacological and Electrophysiological Characterization of Novel NMDA Receptor Antagonists

(2018) Rosana Leiva et al.   ACS Chemical Neuroscience

Revisiting LAMP1 as a marker for degradative autophagy-lysosomal organelles in the nervous system

(2018) Xiu-Tang Cheng et al.   Autophagy

Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid β

(2018) Sara R. Tanqueiro et al.   Frontiers in Pharmacology

Involvement of calpain in the neuropathogenesis of Alzheimer’s disease

(2018) Yacoubou Abdoul Razak Mahaman et al.   MEDICINAL RESEARCH REVIEWS

The mammalian ULK1 complex and autophagy initiation

(2017) Maria Zachari et al.   Essays in Biochemistry

Memantine attenuates cell apoptosis by suppressing the calpain-caspase-3 pathway in an experimental model of ischemic stroke

(2017) Bin Chen et al.   EXPERIMENTAL CELL RESEARCH

Memantine for Alzheimer’s Disease: An Updated Systematic Review and Meta-analysis

(2017) Taro Kishi et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy

(2017) Mikiko Oka et al.   JOURNAL OF BIOCHEMISTRY

Synapsin I phosphorylation is dysregulated by beta-amyloid oligomers and restored by valproic acid

(2017) Jade Marsh et al.   NEUROBIOLOGY OF DISEASE

Combined Memantine and Donepezil Treatment Improves Behavioral and Psychological Symptoms of Dementia-Like Behaviors in Olfactory Bulbectomized Mice

(2017) Yasushi Yabuki et al.   PHARMACOLOGY

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

(2017) Altea Rocchi et al.   PLoS Genetics

Why Women Have More Alzheimer's Disease Than Men: Gender and Mitochondrial Toxicity of Amyloid-β Peptide

(2017) Jose Viña et al.   JOURNAL OF ALZHEIMERS DISEASE

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice

(2016) Christian Griñán-Ferré et al.   Aging-US

Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy

(2016) You-Kyung Lee et al.   BMB Reports

Dysfunction of NMDA receptors in Alzheimer’s disease

(2016) Yan Zhang et al.   NEUROLOGICAL SCIENCES

Cognitive benefits of memantine in Alzheimer's 5XFAD model mice decline during advanced disease stages

(2016) Latha Devi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

GSK-3β-induced Tau pathology drives hippocampal neuronal cell death in Huntington’s disease: involvement of astrocyte–neuron interactions

(2016) F L'Episcopo et al.   Cell Death & Disease

Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies

(2016) Francisco J. Carvajal et al.   NEURAL PLASTICITY

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

Anti-autophagic and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimer's disease via mammalian target of rapamycin-dependent and -independent pathways

(2015) GUIJUN SONG et al.   Molecular Medicine Reports

Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice

(2015) Michael L. Seibenhener et al.   Jove-Journal of Visualized Experiments

Memantine Attenuates Alzheimer’s Disease-Like Pathology and Cognitive Impairment

(2015) Xiaochuan Wang et al.   PLoS One

Novel benzopolycyclic amines with NMDA receptor antagonist activity

(2014) Elena Valverde et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease

(2014) Stéphane D. Girard et al.   HIPPOCAMPUS

Protection of Radial Glial-Like Cells in the Hippocampus of APP/PS1 Mice: a Novel Mechanism of Memantine in the Treatment of Alzheimer’s Disease

(2014) Dayu Sun et al.   MOLECULAR NEUROBIOLOGY

Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice

(2014) M.Y. Liu et al.   NEUROSCIENCE

Autophagy Modulation for Alzheimer’s Disease Therapy

(2013) Xi-Chen Zhu et al.   MOLECULAR NEUROBIOLOGY

Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy

(2013) Chen-Chen Tan et al.   NEUROBIOLOGY OF AGING

Characterization of cognitive deficits in a transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine

(2012) Akira Nagakura et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer’s disease

(2011) Mohammed Filali et al.   NEUROPHARMACOLOGY

Post-synaptic scaffolding protein interactions with glutamate receptors in synaptic dysfunction and Alzheimer's disease

(2011) Dustin T. Proctor et al.   PROGRESS IN NEUROBIOLOGY

Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo

(2011) R Russo et al.   Cell Death & Disease

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Memantine Improves Cognition and Reduces Alzheimer’s-Like Neuropathology in Transgenic Mice

(2009) Hilda Martinez-Coria et al.   AMERICAN JOURNAL OF PATHOLOGY

Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease

(2008) Natalia Louneva et al.   AMERICAN JOURNAL OF PATHOLOGY

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications

(2008) Elliott J Mufson et al.   Expert Review of Neurotherapeutics

Synapsin-I- and synapsin-II-null mice display an increased age-dependent cognitive impairment

(2008) A. Corradi et al.   JOURNAL OF CELL SCIENCE

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging

(2008) Henrieta Scholtzova et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance

(2008) Min Chen et al.   STROKE

Role of N-methyl-D-aspartate receptors in polychlorinated biphenyl mediated neurotoxicity

(2008) Leopold Tchapda Ndountse et al.   TOXICOLOGY LETTERS

Morris Water Maze Experiment

(2008) Joseph Nunez   Jove-Journal of Visualized Experiments