Article
Multidisciplinary Sciences
Veronika Rudolfova, Tomas Petrasek, Eliska Antosova, Daniel Frynta, Eva Landova, Karel Vales, Tereza Nekovarova
Summary: This study tested the repeatability of behavior in the Long Evans strain of laboratory rats and found stable inter-individual differences in behavior, but no evidence of a behavioral syndrome.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Multidisciplinary
L. E. Vossen, E. Nilsson, A. Jansson, E. Roman
Summary: Edible insects, particularly the house cricket, are being promoted as a sustainable source of protein, trace minerals, and lipids for animal feed and human food. This study adapts the open field test, a commonly used behavioral assessment tool for vertebrate model species, to measure the locomotory activity and behavior of house crickets in response to different light intensities. The results show promising potential for the use of the open field test as a precise phenotyping tool in the study of house crickets.
JOURNAL OF INSECTS AS FOOD AND FEED
(2023)
Article
Neurosciences
Jennet L. Baumbach, Cheryl M. McCormick
Summary: Repeated nicotine injections sensitized rats to spend more time in the center of an open field, showing long-lasting sensitization of anxiolytic behavior even in a drug-free state. The mechanisms underlying locomotor sensitization and anxiolytic effects appear to be independent.
PSYCHOPHARMACOLOGY
(2021)
Article
Zoology
Kyoka Shimizu, Keisuke Watanabe, Norifumi Konno, Tomoya Nakamachi, Kouhei Matsuda
Summary: Psychophysiological studies have shown that taxes, such as geotaxis, scototaxis, and thigmotaxis, can be indicators of behavioral change in vertebrates. A study conducted on goldfish measured their preference behaviors in different shaped tanks and found that dark and edge preferences were stable over a short period of time, while lower preference was lost. The study suggests that environmental habituation may depend on the shape of the tank and the elapsed time.
ZOOLOGICAL SCIENCE
(2023)
Article
Psychology, Biological
Erika A. Mehrhoff, Winona C. Booher, Julianna Hutchinson, Grace Schumacher, Curtis Borski, Christopher A. Lowry, Charles A. Hoeffer, Marissa A. Ehringer
Summary: This study explores the effects of anxiolytic drug, diazepam, on High and Low Activity strains of mice, which have extreme differences in open-field activity and are used as a genetic model of anxiety-related behaviors. The results show that diazepam has an anxiolytic effect on the High Activity strain but only reduces stretch attend posture in the Low Activity strains, indicating a more complex phenotype involving innate fear in addition to anxiety-related risk assessment behaviors.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Behavioral Sciences
Andrew C. Harris
Summary: This study evaluated determinants of increased thigmotaxis during mecamylamine-precipitated nicotine withdrawal in rats. Results showed that in adult rats, high dose mecamylamine during nicotine withdrawal led to increased thigmotaxis. However, adolescent rats did not exhibit increased thigmotaxis under the same conditions.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Psychology, Biological
Christiana K. Miller, Amy A. Halbing, Heather B. Patisaul, John Meitzen
Summary: This study on rodents reveals interactions between novelty and estrous cycle phases affecting locomotor and anxiety-related behaviors in females, while novelty impacts male rodents differently under red and white light. Light exposure increases anxiety-related behaviors in both genders but only reduces locomotor behavior in females.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Biochemical Research Methods
Khadijah Shanazz, Rachael Dixon-Melvin, Kristopher M. Bunting, Rebecca Nalloor, Almira I. Vazdarjanova
Summary: The Light-Dark Open Field (LDOF) combines concepts from two tasks to enhance discrimination of anxiety-like behavior. By adding a shadow, the sensitivity of the Open Field task is increased to detect concealed differences even under bright light, while retaining all the advantages of the Open Field. Custom indices from measures collected in the LDOF allow researchers to assess anxiety induced by different stimuli and achieve increased discrimination for anxiety-like behavior.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Chemistry, Medicinal
Barbara Raissa Ferreira de Lima, Leydianne Leite de Siqueira Patriota, Amanda de Oliveira Marinho, Jainaldo Alves da Costa, Thiago Henrique Napoleao, Michelle Melgarejo da Rosa, Patricia Maria Guedes Paiva
Summary: Plant lectin SteLL from Schinus terebinthifolia leaves has anxiolytic effect in mice, increasing the time spent in open arms and depending on monoaminergic signaling cascade.
Review
Behavioral Sciences
Christian J. M. Klein, Thomas Budiman, Judith R. Homberg, Dilip Verma, Jaap Keijer, Evert M. van Schothorst
Summary: Advances in automation and technology have increased the number of methods and systems available for monitoring locomotor activity and behavior in animals. This review discusses existing automated methods that allow for the measurement of locomotor activity and behavior in rodents in their natural laboratory environment. The review also evaluates the suitability of these methods for group-housed animals, in accordance with ethical guidelines, while highlighting their limitations.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Environmental Sciences
Yavuz Yavuz, Deniz Oyku Ozen, Zehra Yagmur Erol, Habibe Goren, Bayram Yilmaz
Summary: There is increasing concern about the effects of endocrine disrupting chemicals (EDCs) on human health, especially their potential impact on energy metabolism and obesity. This study investigated the effects of tributyltin (TBT) and dichlorodiphenyltrichloroethane (p,p'-DDT) on brain circuits controlling feeding and metabolism, and found that these chemicals altered electrical activity in DMHLepR neurons and behavioral state in mice.
ENVIRONMENTAL POLLUTION
(2023)
Article
Pharmacology & Pharmacy
Yusuke Miyazaki, Koji Kobayashi, Seiji Matsushita, Naoyuki Shimizu, Takahisa Murata
Summary: The research developed an SLA measurement system using image analyses to study the movement behavior of BALB/c mice. The study observed the effects of habituation, age, and sex on the mice's spontaneous locomotor activity and found some differences. The findings contribute to a better understanding of animal behavior in their natural breeding environment.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anjelica Cardenas, Yu Bai, Yasamin Hajy Heydary, Jiaqi Li, Frances M. Leslie, Shahrdad Lotfipour
Summary: This study investigates the functional effects of a single nucleotide polymorphism (SNP) in the 3'-UTR of the nicotinic receptor subunit gene, CHRNA6, using knock-in rodent models. The results show that this SNP does not affect baseline behaviors, but enhances nicotine-induced behaviors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Parker Knight, Ranjithkumar Chellian, Ryann Wilson, Azin Behnood-Rod, Stefany Panunzio, Adriaan W. Bruijnzeel
Summary: Female rats exhibit less anxiety-like behavior in the EPM and LOF tests, with sex differences present in almost all behavioral parameters. Additionally, there is a moderate positive correlation between parameters in the EPM and LOF tests.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Cell Biology
Chang Shan, Deng Zhang, Dong-ni Ma, Yan-fang Hou, Qian-qian Zhuang, Yan-ling Gong, Li-hao Sun, Hong-yan Zhao, Bei Tao, Yu-ying Yang, Sheng-tian Li, Jian-min Liu
Summary: Alzheimer's disease is a neurodegenerative disease characterized by amyloid beta peptide accumulation and impaired glucose metabolism in the brain. In this study, the osteoblast-derived protein osteocalcin (OCN) was found to ameliorate anxiety-like behaviors and cognitive dysfunctions in a transgenic AD mice model. OCN reduced amyloid beta burden and improved glycolysis in neuroglia, while also enhancing the neural network function of the brain. These findings suggest that OCN could be a potential therapeutic factor for AD.
CELL DEATH DISCOVERY
(2023)