期刊
ACS CHEMICAL NEUROSCIENCE
卷 9, 期 11, 页码 2722-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.8b00154
关键词
Alzheimer's disease; electrophysiology; glutamate; NMDA receptor; memantine; polycyclic amines
资金
- Ministerio de Economia Industria y Competitividad
- Fondo Europeo de Desarrollo Regional (MINECO-FEDER) [SAF2014-57094-R, BFU2014-57562-P]
- National Institutes of Health [R01MH045817]
- Spanish Ministerio de Education, Cultura y Deporte
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH045817] Funding Source: NIH RePORTER
This work reports the synthesis and pharmacological and electrophysiological evaluation of new N-methyl-D-aspartic acid receptor (NMDAR) channel blocking antagonists featuring polycyclic scaffolds. Changes in the chemical structure modulate the potency and voltage dependence of inhibition. Two of the new antagonists display properties comparable to those of memantine, a clinically approved NMDAR antagonist.
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