Upregulation of MDH1 acetylation by HDAC6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage

Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage

(2021) Takahiko Imai et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity

(2021) Blake R McAlpin et al.   Theranostics

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

TREM-1 Exacerbates Neuroinflammatory Injury via NLRP3 Inflammasome-Mediated Pyroptosis in Experimental Subarachnoid Hemorrhage

(2020) Pengfei Xu et al.   Translational Stroke Research

Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-κB/NLRP3 pathway

(2020) Shuang Xu et al.   ATHEROSCLEROSIS

NOD1/RIP2 signalling enhances the microglia-driven inflammatory response and undergoes crosstalk with inflammatory cytokines to exacerbate brain damage following intracerebral haemorrhage in mice

(2020) Miao Wang et al.   Journal of Neuroinflammation

Histone deacetylase 6 interference protects mice against experimental stroke-induced brain injury via activating Nrf2/HO-1 pathway

(2019) Jie Li et al.   Animal Cells and Systems

Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

(2019) Ashley L. Kalinski et al.   JOURNAL OF CELL BIOLOGY

Quantitative Proteomic Analysis Reveals the Sites Related to Acetylation and Mechanism of ACY-1215 in Acute Liver Failure Mice

(2019) Wen-bin Zhang et al.   Frontiers in Pharmacology

Oligodendrocytes in intracerebral hemorrhage

(2019) Minkyung Kang et al.   CNS Neuroscience & Therapeutics

Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production

(2019) Ruifen Kang et al.   ENVIRONMENTAL POLLUTION

MDH1 deficiency is a metabolic disorder of the malate–aspartate shuttle associated with early onset severe encephalopathy

(2019) Melissa H. Broeks et al.   HUMAN GENETICS

Inhibition of HDAC6 Activity Alleviates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation

(2018) Yan Leng et al.   Oxidative Medicine and Cellular Longevity

Sirt3 Ameliorates Oxidative Stress and Mitochondrial Dysfunction After Intracerebral Hemorrhage in Diabetic Rats

(2018) Jingwei Zheng et al.   Frontiers in Neuroscience

Cerebral hyperperfusion syndrome and intracranial hemorrhage after carotid endarterectomy or carotid stenting: A meta-analysis

(2017) George Galyfos et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport

(2017) Heesun Choi et al.   Molecular Neurodegeneration

Astrocytic Lrp4 (Low-Density Lipoprotein Receptor–Related Protein 4) Contributes to Ischemia-Induced Brain Injury by Regulating ATP Release and Adenosine-A2AR (Adenosine A2A Receptor) Signaling

(2017) Xin-Chun Ye et al.   STROKE

HDAC6 inhibition by tubastatin A is protective against oxidative stress in a photoreceptor cell line and restores visual function in a zebrafish model of inherited blindness

(2017) Janina Leyk et al.   Cell Death & Disease

Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer

(2016) Yi-Ping Wang et al.   MOLECULAR CELL

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

(2016) Xiaochun Duan et al.   Oxidative Medicine and Cellular Longevity

Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation

(2016) Zhifei Wang et al.   Scientific Reports

HIF-1α suppressing small molecule, LW6, inhibits cancer cell growth by binding to calcineurin b homologous protein 1

(2015) Beom Seok Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HDAC6 mediates HIV-1 tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes

(2015) Gi Soo Youn et al.   GLIA

Inhibiting histone deacetylase 6 partly protects cultured rat cortical neurons from oxygen-glucose deprivation-induced necroptosis

(2015) LIMING YUAN et al.   Molecular Medicine Reports

Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly

(2015) Jie Ran et al.   Scientific Reports

HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSα

(2014) Mu Zhang et al.   MOLECULAR CELL

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Cytosolic malate dehydrogenase regulates senescence in human fibroblasts

(2012) Seung-Min Lee et al.   BIOGERONTOLOGY

Acetylation of malate dehydrogenase 1 promotes adipogenic differentiation via activating its enzymatic activity

(2012) Eun Young Kim et al.   JOURNAL OF LIPID RESEARCH

HDAC6 Regulates LPS-Tolerance in Astrocytes

(2011) Eléonore Beurel   PLoS One

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

(2010) Kyle V. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY