Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma

Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich's ataxia fibroblasts

(2021) Floriane Petit et al.   BLOOD

Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic

(2021) Maria Francesca Cordeiro et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Involvement of regulated necrosis in blinding diseases: Focus on necroptosis and ferroptosis

(2020) Jing-Jie Peng et al.   EXPERIMENTAL EYE RESEARCH

Iron metabolism and iron disorders revisited in the hepcidin era

(2020) Clara Camaschella et al.   HAEMATOLOGICA

Ganglion Cell Complex Thickness and Macular Vessel Density Loss in Primary Open-Angle Glaucoma

(2020) Huiyuan Hou et al.   OPHTHALMOLOGY

Adaptive Immunity: New Aspects of Pathogenesis Underlying Neurodegeneration in Glaucoma and Optic Neuropathy

(2020) Shuhong Jiang et al.   Frontiers in Immunology

Systems Genetics of Optic Nerve Axon Necrosis During Glaucoma

(2020) Andrew B. Stiemke et al.   Frontiers in Genetics

Oral administration of the iron chelator deferiprone protects against loss of retinal ganglion cells in a mouse model of glaucoma

(2020) Qi N. Cui et al.   EXPERIMENTAL EYE RESEARCH

Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead

(2020) Raquel Boia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glaucoma as a Neurodegenerative Disease Caused by Intrinsic Vulnerability Factors

(2020) Ana Artero-Castro et al.   PROGRESS IN NEUROBIOLOGY

Retinal energy metabolism in health and glaucoma

(2020) Robert J. Casson et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

(2020) Nicole L Jenkins et al.   eLife

Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy

(2020) Rong Rong et al.   Cell Death & Disease

Simultaneous co-delivery of neuroprotective drugs from multi-loaded PLGA microspheres for the treatment of glaucoma

(2019) A. Arranz-Romera et al.   JOURNAL OF CONTROLLED RELEASE

Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection

(2019) Alejandra Daruich et al.   Science Advances

Current management of glaucoma

(2019) Jed Lusthaus et al.   MEDICAL JOURNAL OF AUSTRALIA

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Iron, Ferritin, Hereditary Ferritinopathy, and Neurodegeneration

(2019) Barry B. Muhoberac et al.   Frontiers in Neuroscience

The ferroportin-ceruloplasmin system and the mammalian iron homeostasis machine: regulatory pathways and the role of lactoferrin

(2018) Maria Carmela Bonaccorsi di Patti et al.   BIOMETALS

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux

(2018) Min Chen et al.   Redox Biology

Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration

(2018) Shashank Masaldan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Divalent Metal Transporter 1 (DMT1) is required for iron uptake and normal development of oligodendrocyte progenitor cells

(2018) VT Cheli et al.   JOURNAL OF NEUROSCIENCE

Did you choose appropriate tracer for retrograde tracing of retinal ganglion cells? The differences between cholera toxin subunit B and Fluorogold

(2018) Fei Yao et al.   PLoS One

The Role of Deferiprone in Iron Chelation

(2018) Robert C. Hider et al.   NEW ENGLAND JOURNAL OF MEDICINE

The involvement of iron responsive element (-) divalent metal transporter 1-mediated the spinal iron overload via CXCL10/CXCR3 pathway in neuropathic pain in rats

(2018) Weituan Xu et al.   NEUROSCIENCE LETTERS

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Proteomic Analysis of Various Rat Ocular Tissues after Ischemia–Reperfusion Injury and Possible Relevance to Acute Glaucoma

(2017) Hsin-Yi Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glaucoma

(2017) Jost B Jonas et al.   LANCET

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Targeting Oxidative Stress for Treatment of Glaucoma and Optic Neuritis

(2017) Atsuko Kimura et al.   Oxidative Medicine and Cellular Longevity

The inner blood-retinal barrier: Cellular basis and development

(2017) Mónica Díaz-Coránguez et al.   VISION RESEARCH

Diverse Central Projection Patterns of Retinal Ganglion Cells

(2017) Emily M. Martersteck et al.   Cell Reports

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Mice with hepcidin-resistant ferroportin accumulate iron in the retina

(2016) Milan Theurl et al.   FASEB JOURNAL

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Association Between Serum Ferritin and Glaucoma in the South Korean Population

(2014) Shuai-Chun Lin et al.   JAMA Ophthalmology

Adverse events and complications associated with intravitreal injection of anti-VEGF agents: a review of literature

(2013) K Ghasemi Falavarjani et al.   EYE

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Iron, zinc, and copper in retinal physiology and disease

(2013) Marta Ugarte et al.   SURVEY OF OPHTHALMOLOGY

Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species

(2012) Chu-Chiao Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina

(2012) Delu Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protecting the retinal neurons from glaucoma: Lowering ocular pressure is not enough

(2012) Alessia Pascale et al.   PHARMACOLOGICAL RESEARCH

The molecular basis of retinal ganglion cell death in glaucoma

(2011) Mohammadali Almasieh et al.   PROGRESS IN RETINAL AND EYE RESEARCH